|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Model combining pre-transplant tumor biomarkers and tumor size shows more utility in predicting hepatocellular carcinoma recurrence and survival than the BALAD models显示文摘AIM To assess the performance of BALAD, BALAD-2 and their component biomarkers in predicting outcome of hepatocellular carcinoma(HCC) patients after liver transplant.METHODS BALAD score and BALAD-2 class are derived from bilirubin, albumin, alpha-fetoprotein(AFP), Lens culinaris agglutinin-reactive AFP(AFP-L3), and des-gammacarboxyprothrombin(DCP). Pre-transplant AFP, AFP-L3 and DCP were measured in 113 patients transplanted for HCC from 2000 to 2008. Hazard ratios(HR) for recurrence and death were calculated. Univariate and multivariate regression analyses were conducted. C-statistics were used to compare biomarker-based to predictive models. RESULTS During a median follow-up of 12.2 years, 38 patients recurred and 87 died. The HRs for recurrence in patients with elevated AFP, AFP-L3, and DCP defined by BALAD cut-off values were 2.42(1.18-5.00), 1.86(0.98-3.52), and 2.83(1.42-5.61), respectively. For BALAD, the HRs for recurrence and death per unit increased score were 1.48(1.15-1.91) and 1.59(1.28-1.97). For BALAD-2, the HRs for recurrence and death per unit increased class were 1.45(1.06-1.98) and 1.38(1.09-1.76). For recurrence prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs. 0.64, 0.61, 0.53, and 0.53 for BALAD, BALAD-2, Milan, and UCSF, respectively. Similarly, for death prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs 0.65,0.61, 0.52, and 0.50 for BALAD, BALAD-2, Milan, and UCSF. A new model combining biomarkers with tumor size at the time of transplant(S-LAD) demonstrated the highest predictive capability with c-statistics of 0.71 and 0.69 for recurrence and death. CONCLUSION BALAD and BALAD-2 are valid in transplant HCC patients, but less predictive than the three biomarkers in combination or the three biomarkers in combination with maximal tumor diameter(S-LAD). | Nicha Wongjarupong Gabriela M Negron-Ocasio Roongruedee Chaiteerakij Benyam D Addissie Essa A Mohamed Kristin C Mara William S Harmsen J Paul Theobald Brian E Peters Joseph G Balsanek Melissa M Ward Nasra H Giama Sudhakar K Venkatesh Denise M Harnois Michael R Charlton Hiroyuki Yamada Alicia Algeciras-Schimnich Melissa R Snyder Terry M Therneau Lewis R Roberts | 2018 | World Journal of Gastroenterology2018，24，12： | 5 |
| 2 | Trust as a social reality显示文摘 | Lewis J D Weigert A | 1985 | Social Forces1985，63，4： | 1 |
| 3 | Trust as a Social Reality 显示文摘 | Lewis J D Weigert A | 1985 | Social Force1985，63，4： | 1 |
| 4 | Role of oxidative changes in the degeneration of dopamine terminals after injection of neurotoxic levels of dopamine显示文摘 | Rabinovic A D Lewis D A Hastings T G | 2000 | Neuroscience2000，101，1： | 1 |
| 5 | Knee joint motion and ligament forces before and after ACL reconstruction 显示文摘 | Lewis J L Lew W D Hill J A | 1989 | Journal of Biomechanical Engineering1989，111，： | 1 |
| 6 | Alhydrogel adjuvant, ultrasonic dispersion and protein binding:a TEM and analytical study 显示文摘 | Harris JR Soliakov A Lewis RJ et d | 2012 | Micron2012，43，23： | 1 |
| 7 | Dilution of mainstreamtobacco smoke and its effects upon the evaporation anddiffusion of nicotine显示文摘 | Lewis D A Colbeck I Mariner D C | 1995 | Journal of Aerosol Science1995，26，5： | 1 |
| 8 | Predictors of persistent pain after total knee arthroplasty: a systematic review and meta-analysis 显示文摘 | Lewis G N Rice D A McNair P J | 2015 | Br J Anaesth2015，114，4： | 1 |
| 9 | Structure-function relations of heparin-mimetic sulphated xylan-oligosaccharides inhibition of Human Immunodeficiency Virus-1 infectivity in vitro显示文摘 | Stone A L Melton D J Lewis M S | 1998 | GlycoconjugateJournal1998，15，： | 1 |
| 10 | Flow cytometric analysis of circulating microparticles in plasma显示文摘 | OROZCO A F LEWIS D E | 2010 | Cytometry2010，77，6： | 1 |
| 11 | Storage of sediment-associated nutrients and contaminants in river channel and floodplain systems显示文摘 | Walling D E Owens P N Carter J Leeks G J L Lewis S Meharg A A and Wright J | 2003 | Applied Geochemistry2003，18，： | 1 |
| 12 | The effect of microbial phytase in a pearl millet-soybean meal diet on apparent digestibility and retention of nutrients,serum mineral concentration,and bone mineral density of nurscry pigs显示文摘 | MURRY A C LEWIS R D AMOS H E | 1997 | J Anim Sci1997，75，： | 1 |
| 13 | Thalassiosira species (Bacillariophyceae) from a Scottish sea-loch 显示文摘 | Harris A S D Medlim L K Lewis J | 1995 | European Journal ofPhycology1995，30，2： | 1 |
| 14 | Determination of aerylamide in various food matrices: evaluation of LC and GC mass spectrometric methods显示文摘 | Becalski A Lau BP Lewis D | 2005 | Adv Exp Med Biol2005，561，： | 1 |
| 15 | An intercomparison of sampling techniques for nicotine in indoor environments显示文摘 | Caka F M Eatough D J Lewis E A | 1994 | Environmental Science and Technology1994，24，8： | 1 |
| 16 | Recurrent epidemic cycles in an infectious disease model with a time delay in loss of vaccine immunity 显示文摘 | Greenhalgh D Khan Q J A Lewis F I | 2005 | Nonl Anal TMA2005，63，6： | 1 |
| 17 | Metabolite identificationvia the Madison metabolomics consortium database 显示文摘 | Cui Q Lewis I A Hegeman A D | 2008 | Nat Bio-technol2008，26，2： | 1 |
| 18 | Dredging impact on an urbanized Florida bayou, effects on benthos and algal-periphyton显示文摘 | LEWIS M A WEBER D E STANLEY R S | 2001 | Environmental Pollution2001，115，2： | 1 |
| 19 | Induction of tumorigen-esis and metastasis by the murine orthologue of tumor protein D52 显示文摘 | Lewis J D Payton L A Whitford J G | 2007 | Mol Cancer Res2007，5，2： | 1 |
| 20 | The epidemiology of hearing problems:How should we investigate it? 显示文摘 | Stephens D Lewis P Davis A | 2004 | Acta Otolaryngol2004，552，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员