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| 1 | Mycophenolate mofetil for maintenance of remission in steroid-dependent autoimmune pancreatitis显示文摘Systemic corticosteroids represent the standard treatment for autoimmune pancreatitis with IgG4-associated cholangitis.For steroid-dependent disease,azathioprine has been used for maintenance of remission.Mycophenolate mofetil has been used for transplant immunosuppression and more recently for autoimmune hepatitis;however,there are no case reports to date on the use of mycophenolate mofetil in adult patients with autoimmune pancreatitis.A patient with IgG4-mediated autoimmune pancreatitis and IgG4-associated cholangitis refractory to steroids and intolerant of azathioprine was treated with mycophenolate mofetil,which inhibits de novo guanosine synthesis and blockade of both B and T lymphocyte production.Introduction of mycophenolate mofetil and uptitration to 1000 mg by mouth twice daily over a treatment period of 4 mo was associated with improvement in the patient's energy level and blood glucose control and was not associated with any adverse events.The patient was managed without a biliary stent.However,there was a return of symptoms,jaundice,increase in transaminases,and hyperbilirubinemia when the prednisone dose reached 11 mg per day.In the first report of mycophenolate mofetil use in an adult patient with IgG4-associated autoimmune pancreatitis and IgG4-associated cholangitis,the introduction of mycophenolate mofetil was safe and well-tolerated without adverse events,but it did not enable discontinuation of the steroids.Mycophenolate mofetil and other immunomodulatory therapies should continue to be studied for maintenance of remission in the large subset of patients with refractory or recurrent autoimmune pancreatitis. | Jamie B Sodikoff Steven A Keilin Sheila J Bharmal Melinda M Lewis Gottumukkala S Raju Field F Willingham | 2012 | World Journal of Gastroenterology2012，18，18： | 6 |
| 2 | PrP^C-related signal transduction is influenced by copper, membrane integrity and the alpha cleavage site显示文摘铜绑定,抛锚膜的、细胞的 prion 蛋白质(PrPC ) 有二个组成的劈开地点生产不同 N 终端和 C 终端碎片(N1/C1 和 N2/C2 ) 。用表示也人的 PrPC,鼠标 PrPC 或鼠标 PrPC 的 RK13 房间带 3F4 epitope,这研究在 endoproteolytic 劈开和一个通常认为的 PrPC 函数上探索了 PrPC 主要顺序的影响,地图 kinase 信号 transduction,响应外长的铜与或没有使不安的膜环境。PrPC 主要顺序,特别在 N1/C1 劈开地点附近,看起来在这个地点和细胞外的调整信号的 kinase 1/2 (ERK1/2 ) phosphorylation 影响解朊作用的基础层次,与处理激活增加与基础 ERK1/2 表明一种反的关系。人的 PrPC 独自响应铜显示出增加的 N1/C1 劈开,由特定的 p38 和 JNK/SAPK phosphorylation 伴随了。到加扣押胆固醇的抗菌素 filipin 的铜的联合暴露导致了一只老鼠信号蛋白质 phosphorylation 的 PrPC 特定的实质的增加,由 N1/C1 劈开的增加伴随了。怀有人的 N1/C1 劈开地点的老鼠 PrPC 基础地并且响应铜假定更似人类的侧面并且改变了膜环境。我们的结果证明在 N1/C1 劈开地点附近的 PrPC 主要顺序影响在这个地点处理的 endoproteolytic,它显得连接了基础地并且响应铜印射 kinase 信号 transduction。进一步,主要顺序看起来响应外长的刺激在 PrPC 相关的信号 transduction 的忠实上授与 N1/C1 劈开和膜完整的相互的依赖。 | Cathryn L Haigh | 2009 | Cell Research2009，19，9： | 4 |
| 3 | Adaptive fuzzy logic control of discrete-time dynamical systems 显示文摘 | Jagannathan A Vandegrift M W Lewis F L | 2000 | Automatica2000，36，2： | 2 |
| 4 | Characterisation of single stage,dual-pumped Raman fibre amplifiers for different gain fibre lengths 显示文摘 | KOCH F CHERNIKOV S V LEWIS S A E | 2000 | Electron Lett2000，36，4： | 2 |
| 5 | Thiazolo pyrimidines: 1 : synthesis and anti-human cytomegalovirus (HCMV) activity in-vitro of certain alkyl derivatives显示文摘 | Lewis A F Revankar G R Fennewald S M | 1995 | J Heterocycl Chem1995，32，20： | 1 |
| 6 | Feedback linearization using neural networks显示文摘 | Yesildirec A Lewis F L | 1995 | Automatica1995，31，11： | 1 |
| 7 | Discrete-time non- linear HJB solution using approximate dynamic programming: Convergence proof显示文摘 | Al-Tamimi A Lewis F L Abu-Khalaf M | 2008 | IEEE Transactions on Systems Man and Cybernetics Part B: Cybernetics2008，38，4： | 1 |
| 8 | Chained aggregation of singular system显示文摘 | Christodoulou M A Mertzios B G | 1989 | IEEE Trans on Automatic and Control1989，34，9： | 1 |
| 9 | Flow cytometric analysis of circulating microparticles in plasma显示文摘 | OROZCO A F LEWIS D E | 2010 | Cytometry2010，77，6： | 1 |
| 10 | An intercomparison of sampling techniques for nicotine in indoor environments显示文摘 | Caka F M Eatough D J Lewis E A | 1994 | Environmental Science and Technology1994，24，8： | 1 |
| 11 | Recurrent epidemic cycles in an infectious disease model with a time delay in loss of vaccine immunity 显示文摘 | Greenhalgh D Khan Q J A Lewis F I | 2005 | Nonl Anal TMA2005，63，6： | 1 |
| 12 | Variations of Lactoperoxidase Activity and Thioeyanate Content in Cows' and Goats' Milk throughout Lactation显示文摘 | FONTEH F GRANDISON A LEWIS M | 2002 | Journal of Dairy Research2002，69，3： | 1 |
| 13 | A strip adjustment approach for precise georeferencing of ALOS optical imagery显示文摘 | Rottensteiner F Weser T Lewis A | 2009 | IEEE Transactions on Geoscience and Remote Sensing2009，47，12： | 1 |
| 14 | Character-isation of single state, dual-pumped Raman fibre amplifiers for different gain fibre lengths 显示文摘 | Koch F Chernikov S V Lewis S A E | 2000 | Electron Letters2000，36，4： | 1 |
| 15 | Multilayer neural-net robot controller with guaranteed tracking performance 显示文摘 | Lewis F L Yesildirek A Liu K | 1996 | IEEE Transactions on Neural Networks1996，7，2： | 1 |
| 16 | Multilayer neural-net robot controller with guaranteed tracking performance显示文摘 | LEWIS F L YESILDIREK A UU K | 1996 | IEEE Transactions on Neural Networks1996，7，2： | 1 |
| 17 | CriticalSorb: a novel effi- cient nasal delivery system for human growth hormone based on Solutol HS15 显示文摘 | Ilium L Jordan F Lewis A L | 2012 | J Controlled Release2012，162，1： | 1 |
| 18 | Neural net robot controller with guaranteed tracking performance 显示文摘 | Lewis F L Yesildirek A Liu K | 1995 | IEEE Transactions on Neural Networks1995，6，： | 1 |
| 19 | Feedback linearization using neural networks显示文摘 | YESILDIREK A LEWIS F L | 1995 | Automatica1995，31，11： | 1 |
| 20 | Multilayer Neural-net Robot Controller with Guaranteed Tracking Performance 显示文摘 | Lewis F L Yesildirek A Liu K | 1996 | IEEE Transactions on Neural Networks1996，7，2： | 1 |
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