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| 1 | Model combining pre-transplant tumor biomarkers and tumor size shows more utility in predicting hepatocellular carcinoma recurrence and survival than the BALAD models显示文摘AIM To assess the performance of BALAD, BALAD-2 and their component biomarkers in predicting outcome of hepatocellular carcinoma(HCC) patients after liver transplant.METHODS BALAD score and BALAD-2 class are derived from bilirubin, albumin, alpha-fetoprotein(AFP), Lens culinaris agglutinin-reactive AFP(AFP-L3), and des-gammacarboxyprothrombin(DCP). Pre-transplant AFP, AFP-L3 and DCP were measured in 113 patients transplanted for HCC from 2000 to 2008. Hazard ratios(HR) for recurrence and death were calculated. Univariate and multivariate regression analyses were conducted. C-statistics were used to compare biomarker-based to predictive models. RESULTS During a median follow-up of 12.2 years, 38 patients recurred and 87 died. The HRs for recurrence in patients with elevated AFP, AFP-L3, and DCP defined by BALAD cut-off values were 2.42(1.18-5.00), 1.86(0.98-3.52), and 2.83(1.42-5.61), respectively. For BALAD, the HRs for recurrence and death per unit increased score were 1.48(1.15-1.91) and 1.59(1.28-1.97). For BALAD-2, the HRs for recurrence and death per unit increased class were 1.45(1.06-1.98) and 1.38(1.09-1.76). For recurrence prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs. 0.64, 0.61, 0.53, and 0.53 for BALAD, BALAD-2, Milan, and UCSF, respectively. Similarly, for death prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs 0.65,0.61, 0.52, and 0.50 for BALAD, BALAD-2, Milan, and UCSF. A new model combining biomarkers with tumor size at the time of transplant(S-LAD) demonstrated the highest predictive capability with c-statistics of 0.71 and 0.69 for recurrence and death. CONCLUSION BALAD and BALAD-2 are valid in transplant HCC patients, but less predictive than the three biomarkers in combination or the three biomarkers in combination with maximal tumor diameter(S-LAD). | Nicha Wongjarupong Gabriela M Negron-Ocasio Roongruedee Chaiteerakij Benyam D Addissie Essa A Mohamed Kristin C Mara William S Harmsen J Paul Theobald Brian E Peters Joseph G Balsanek Melissa M Ward Nasra H Giama Sudhakar K Venkatesh Denise M Harnois Michael R Charlton Hiroyuki Yamada Alicia Algeciras-Schimnich Melissa R Snyder Terry M Therneau Lewis R Roberts | 2018 | World Journal of Gastroenterology2018，24，12： | 5 |
| 2 | Robust Adaptive Control of Induction Motors Without Flux Measurment显示文摘 | Kwan C M Lewis F L Yeung K S | 1995 | ACC1995，32，6： | 1 |
| 3 | Toxicity comparison of biosurfactants and synthetic surfactants used in oil spill remediation to two estuarine species显示文摘 | Edwards K R Lepo J E Lewis M A | 2003 | Marine Pollution Bulletin2003，46，10： | 1 |
| 4 | Identification of urocortin III,an additional member of the corticotrophin-releasing factor (CRF) family with high affinity for the CRF2 receptor显示文摘 | Lewis K Li C Perrin M H | 2001 | Proc Natl Acad Sci USA2001，98，13： | 1 |
| 5 | Justice Constructs, Negative Affectivity, and Employee Deviance: A Proposed Model and Empirical Test 显示文摘 | AQUINO K LEWIS M U BRADFIELD M | 1999 | Journal of Organizational Behavior1999，20，7： | 1 |
| 6 | Web space reconstruction with a M-V flap显示文摘 | LEWIS R C NORDYKE M D DUNCAN K H | 1988 | J Hand Surg Am1988，13，1： | 1 |
| 7 | Clindamycin in dentistry:More than just effective prophylaxis for endocarditis显示文摘 | Brook I Lewis M A O Sandor G K B | 2005 | Oral Surg Oral Med Oral Pathol Oral Radiol Endod2005，100，： | 1 |
| 8 | Effects of alkaline hydrogen peroxide treatment on in vitro degradation of cellulosic substrates by mixed ruminal microorganisms and Bacteroides succinogenes S85显示文摘 | Lewis S M Montgomeryl Garleb K A | 1988 | Appl Environ Microbiol1988，54，： | 1 |
| 9 | Effects of alkaline hydrogen peroxide treatment on in vitro degradation of cellulosic substrates by mixed ruminal microorganisms and bacteroides succinogenes S85显示文摘 | Lewis S M Montgomery L Garleb K A | 1988 | Appl Envion Microbiol1988，54，5： | 1 |
| 10 | Minerals, phytic acid, )znnin and rutin in buckwheat seed inilling fractions显示文摘 | STEADMAN K J BURGOON M S LEWIS B A | 2001 | Sci Food and Agrie2001，81，： | 1 |
| 11 | High Precision Formation Control of Mobile Robots Using Virtual Structures显示文摘 | Lewis M Tan K H | 1997 | Autonomous Ro- bots1997，4，4： | 1 |
| 12 | Scales to measure perccivcd control developed specifically for people with tablettreated diaberes 显示文摘 | Bradley C Lewis K S Jennings A M | 1990 | Diabet Med1990，7，8： | 1 |
| 13 | Integrating justice and social exchange: The differing effects of fair procedures and treatment on work relationships 显示文摘 | MASTERSON S S LEWIS K GOLDMAN B M | 2000 | Academy of Management Journal2000，43，4： | 1 |
| 14 | Innovation- supportive culture : The impact of organizational values on process innovation 显示文摘 | KHAZANCHI S LEWIS M W BOYER K K | 2007 | Journal of Operations Management2007，，25： | 1 |
| 15 | Urocortin II ;a member of the corticotropin-releasing (actor (CRF) neuropeptide family that is selectively bound by type 2 CRF receptors显示文摘 | Reyes T M Lewis K Perrin M H | 2001 | Proc Natl Acad Sci USA2001，98，： | 1 |
| 16 | Rapid-fire fulfillment显示文摘 | Ferdows K Lewis M A Maehuea J A D | 2004 | Harvard Business Review2004，82，11： | 1 |
| 17 | Diseases of the submandibular gland as demonstrated using high resolution ultrasound 显示文摘 | Alyas F Lewis K Williams M | 2005 | Br J Ra- diol2005，78，928： | 1 |
| 18 | Accelerated aging of annealed proton-exchanged waveguides显示文摘 | Kissa K M Suchoski P G D Lewis D K | 1995 | Light- wave technology1995，13，7： | 1 |
| 19 | Kinematic analysis of a stewart platform manuipulator显示文摘 | Liu K Fitzgerald J M Lewis F L | 1993 | IEEE Transactions on industrial electronics1993，4，2： | 1 |
| 20 | Identification of urocortin M,an additional member of the corticotropin-releasing factor (CRF) family with high affinity for the CRF2 receptor显示文摘 | Lewis K Li C Perrin M H | 2001 | Proc Natl Acad Sci USA2001，98，5： | 1 |
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