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| 1 | Nat Genet:单细胞分析解开结直肠癌细胞的神秘面纱显示文摘结合单细胞基因组学和计算机技术,一个研究团队(包括来自杰克逊实验室(JAx)单细胞生物学主任Paul Robson博士在内)鉴定出了11种结直肠癌肿瘤的癌细胞组成及邻近的非癌细胞。这对于更好的肿瘤靶向诊断和治疗很重要。”使用单细胞测序。”JAX科学家、这篇发表在Nature Genetics上的文章共同第一作者Elise Courtois说道。”我们可以根据肿瘤中的细胞组成将结直肠癌进一步分类。因为每种亚型的肿瘤病人生存率存在差别,我们的方法将为肿瘤医生提供更多的关于肿瘤预后和治疗的信息。” | Huipeng Li, Elise T Courtois, Debarka Sengupta, Yuliana Tan Shyam Prabhakar Elise T Courtois, Yuliana Tan Paul Robson Debarka Sengupta Kok Hao Chen, Jolene Jie Lin Goh Paul Jongjoon Choi Say Li Kong, Axel M Hillmer Iain Beehuat Tan Clarinda Chua Iain Beehuat Tan Lim Kiat Hon Wah Siew Tan Mark Wong Lawrence J K Wee Iain Beehuat Tan Paul Robson Paul Robson Paul Robson | 2017 | 现代生物医学进展2017，17，15： | 37 |
| 2 | Purification of Crude Glycerol from Waste Cooking Oil Based Biodiesel Production by Orthogonal Test Method显示文摘Purification of original crude glycerol obtained from biodiesel production was conducted in a laboratory scale equipment by means of a combined chemical and physical treatment method based upon repeated cycles of acidification of liquid phase to the desired pH value by using 5.85% H3PO4 solution for pH value adjustment, and the mixture was kept at 70℃ for 60min to make phase separation for obtaining a glycerol-rich middle phase. The yield of crude glycerol reached 81.2%. Subsequently, upon reaction of the obtained glycerol phase with 0.03% of sodium oxalate at 80℃ for 30min the impurity removal rate was equal to 19.8%. The fraction boiling between 164℃ and 200℃ was collected by vacuum distillation followed by decolorization with 2% of active carbon at 80℃ for two times to yield the product glycerol with an acceptable purity of 98.10%. | Cai Tianfeng Li Huipeng Zhao Hua Liao Kejian | 2013 | China Petroleum Processing & Petrochemical Technology2013，15，1： | 4 |
| 3 | Oxidation-extraction desulfurization of model oil over Zr-ZSM-5/SBA-15 and kinetic study显示文摘 | Chuanzhu LU Hui FU Huipeng LI Hua ZHAO Tianfeng CAI | 2014 | Frontiers of Chemical Science and Engineering2014，8，2： | 4 |
| 4 | Band-tailored van der Waals heterostructure for multilevel memory and artificial synapse显示文摘Two-dimensional(2D)van der Waals heterostructure(vdWH)-based floating gate devices show great potential for next-generation nonvolatile and multilevel data storage memory.However,high program voltage induced substantial energy consumption,which is one of the primary concerns,hinders their applications in lowenergy-consumption artificial synapses for neuromorphic computing.In this study,we demonstrate a three-terminal floating gate device based on the vdWH of tin disulfide(SnS2),hexagonal boron nitride(h-BN),and few-layer graphene.The large electron affinity of SnS2 facilitates a significant reduction in the program voltage of the device by lowering the hole-injection barrier across h-BN.Our floating gate device,as a nonvolatile multilevel electronic memory,exhibits large on/off current ratio(105),good retention(over 104 s),and robust endurance(over 1000 cycles).Moreover,it can function as an artificial synapse to emulate basic synaptic functions.Further,low energy consumption down to7 picojoule(pJ)can be achieved owing to the small program voltage.High linearity(<1)and conductance ratio(80)in long-term potentiation and depression(LTP/LTD)further contribute to the high pattern recognition accuracy(90%)in artificial neural network simulation.The proposed device with attentive band engineering can promote the future development of energy-efficient memory and neuromorphic devices. | Yanan Wang Yue Zheng Jing Gao Tengyu Jin Enlong Li Xu Lian Xuan Pan Cheng Han Huipeng Chen Wei Chen | 2021 | InfoMat2021，3，8： | 3 |
| 5 | SUBDIVIDING VERBS TO IMPROVE SYNTACTIC PARSING显示文摘This paper proposes a new way to improve the performance of dependency parser: subdividing verbs according to their grammatical functions and integrating the information of verb subclasses into lexicalized parsing model. Firstly,the scheme of verb subdivision is described. Secondly,a maximum entropy model is presented to distinguish verb subclasses. Finally,a statistical parser is developed to evaluate the verb subdivision. Experimental results indicate that the use of verb subclasses has a good influence on parsing performance. | Liu Ting Ma Jinshan Zhang Huipeng Li Sheng | 2007 | Journal of Electronics(China)2007，24，3： | 2 |
| 6 | A New Indicator for Global Food Security Assessment: Harvested Area Rather Than Cropland Area显示文摘Cropland area has long been used as a key indicator of food security.However,grain yield is not solely controlled by the area of the cropland.Therefore,we proposed a new indicator to assess food security.Results show that from 1992 to 2004,the global cropland area increased by 840200 km^(2)(99.4%),but the grain yield increased only by 310 million t(29.1%);and from 2004 to 2015,the cropland area decreased by 39000 km^(2)(4.64%),but the grain yield increased by 370 million t(70.84%).This result showed that grain yield was not linearly correlated with cropland area,and delimiting the threshold of cropland protection may not guarantee food security.Combined with further correlation analysis,we found that the increase in the global grain yield was more closely related to the harvested area(R^(2)=0.94),which indicated that the harvested area is a more scientific and accurate indicator than cropland area in terms of guaranteeing food security.Therefore,if governments want to ensure the food security,they should choose a new and more accurate indicator:harvested area rather than cropland area. | SONG Fengjiao WANG Shijie BAI Xiaoyong WU Luhua WANG Jinfeng LI Chaojun CHEN Huan LUO Xuling XI Huipeng ZHANG Sirui LUO Guofeng YAN Mengqi ZHEN Qingqing | 2022 | Chinese Geographical Science2022，32，2： | 2 |
| 7 | One-step Synthesis and Photocatalytic Degradation Performance of Sulfur-doped Porous g-C_(3)N_(4)Nanosheets显示文摘In this study,the sulfur-doped porous g-C_(3)N_(4) nanosheets(CN-T-U 1.75)were synthesized successfully by onestep calcination utilizing urea and thiourea as precursors.Under visible light irradiation,CN-T-U 1.75 showed remarkable photocatalytic activity for Rhodamine B(RhB)degradation with a kinetic reaction rate constant of 0.01838 min^(-1).The characterization analysis indicated that CN-T-U 1.75 had a higher specific surface area and the doping altered the energy band structure.This work offers a new viewpoint on modifying the band structure of a photocatalyst using a doping strategy,as well as new insights into the generation routes of active species involved in the photocatalytic process. | Liu Yuan Zhao Hua Li Huipeng Cai Tianfeng | 2022 | China Petroleum Processing & Petrochemical Technology2022，24，1： | 2 |
| 8 | Orbitofrontal cortex action of 5-hydroxytryptamine and its receptor in an acute forced swimming stress-induced depression model显示文摘BACKGROUND:The orbitofrontal cortex(OFC) is a brain region closely associated with emotion. 5-hydroxytryptamine(5-HT) has been shown to be involved in human depression. OBJECTIVE:To investigate OFC actions and mechanisms of 5-HT and 5-HT_(1A) receptor(5-HT_(1A)R) in stress-induced depression. DESIGN,TIME AND SETTING:A randomized,controlled,animal experiment was performed at Laboratory of Neurobiology,College of Life Science,Shaanxi Normal University between May 2006 and March 2008. MATERIALS:5-HT,p-chlorophenylalanine(PCPA,an inhibitor to tryptophan hydroxylase) and spiperone(5-HT_(1A)R antagonist) were provided by Sigma,USA;rabbit anti-rat 5-HT_(1A)R antibody was provided by Tianjin Haoyang Biological Manufacture. METHODS:A total of 40 male Sprague Dawley rats,aged 3 months,were randomly divided into five groups:control,model,5-HT,spiperone+5-HT,and PCPA,with 8 rats in each group.Except for control group,rats in the other four groups were used to establish depression models by forced swimming for 15 minutes.At 30 minutes before forced swimming test,0.5μL of 5-HT(12.5μg/μL), PCPA(20μg/μL),spiperone(1.3μg/μL)+5-HT(12.5μg/μL,10 minutes later),and saline were respectively injected into the OFC of 5-HT,PCPA,spiperone+5-HT,and model groups,respectively. The control group received a saline microinjection into the OFC. MAIN OUTCOME MEASURES:Forced swimming and open field tests were employed to measure animal behaviors,and immunohistochemistry was used to analyze 5-HT_(1A)R expression in the OFC, cingulate cortex,and piriform cortex. RESULTS:(1) Compared with the model group,5-HT microinjection into the OFC prominently reduced immobility time in the forced swimming test and rearing in open field test(P<0.05); locomotion and grooming in open field test were increased,although there was no significance(P>0.05).Furthermore,following PCPA microinjection into the OFC(PCPA+forced swimming stress), immobility time in forced swimming test increased dramatically(P<0.01),locomotion and rearing in open field test declined(P<0.05 and P<0.01,respectively).Compared with the 5-HT group, 5-HT_(1A)R antagonist(spiperone+5-HT+forced swimming stress) increased immobility time in forced swimming test(P<0.01),but decreased locomotion,rearing,and grooming in open field test. (2) Forced swimming stress markedly elevated 5-HT_(1A)R expression in OFC,cingulate cortex,and piriform cortex(P<0.05 or P<0.01). CONCLUSION:5-HT improved stress-induced depression,and 5-HT anti-depression effects are primarily achieved via 5-HT_(1A)R.Stress-induced up regulation of 5-HT_(1A)R expression might be a compensatory mechanism for decreased 5-HT expression. | Huipeng Li Fengli An Shucheng An | 2009 | Neural Regeneration Research2009，4，7： | 2 |
| 9 | Porous and free-standing Ti3C2Tx-RGO film with ultrahigh gravimetric capacitance for supercapacitors显示文摘MXene-based electrode materials exhibit favorable supercapacitor performance in sulfuric acid due to praised pseudocapacitance charge storage mechanism.However,self-stacking of conventional MXene electrodes severely restricts their electrochemical performance,especially at high loading.Herein,a flexible cross-linked porous Ti3C2Tx-MXene-reduced graphene oxide(Ti3C2Tx-RGO)film is skillfully designed and synthesized by microscopic explosion of graphene oxide(GO)at sudden high te mperature.The generated chamber structure between layers could hold a few of electrolyte,leading to a close-fitting reaction at interlayer and avoiding complex ions transmission paths.The Ti3C2Tx-RGO film displayed a preferable rate performance than that of pure Ti3C2Tx film and a high capacitance of 505 F/g at 2 mV/s.Furthermore,the uniform intralayer structure and unique energy storage process lead to thicknessindependenct electrochemical performances.This work provides a simple and feasible improvement approach for the design of MXene-based electrodes,which can be spread other electrochemical systems limited by ions transport,such as metal ions batteries and catalysis. | Yongzheng Fang Bowen Yang Dongtong He Huipeng Li Kai Zhu Lin Wu Ke Ye Kui Cheng Jun Yan Guiling Wang Dianxue Cao | 2020 | Chinese Chemical Letters2020，31，4： | 2 |
| 10 | Acylation of Anisole Catalyzed by Hierarchical Porous Hβ Zeolite Modified with Cr显示文摘 | LI Guohua LI Huipeng ZHAO Hua CAI Tianfeng LI Yange GUAN Shengnan | 2018 | Chemical Research in Chinese Universities2018，34，6： | 1 |
| 11 | A networked swellable dextrin nanogels loading Bcl2 siRNA for melanoma tumor therapy显示文摘在这研究,联网的可胀大的糊精 nanogel (DNG ) 被开发完成刺激应答的小介入为黑瘤肿瘤的 RNA (siRNA ) 版本治疗。siRNA 被费用冷凝作用装进多维的糊精 nanogels,积极精氨酸残余在糊精脊梁修改了。而且,联网的 nanogel 被破坏并且基于它的 bioreducible 松开了应答的性质在 bioreducible 控制加速的 siRNA 版本细胞内部的环境,当它在正常生理的条件下面仍然保持稳定时。我们由传播电子显微镜学评估在减少的缓冲区状况下面表明了可胀大的有的那 DNG 和拆卸性质。DNG 完成了被触发谷胱甘肽的拆卸货物的选择版本根据共焦的显微镜学观察跟随进 cytosol 的 endosomal 逃跑。因此,这聪明的 nanogel 完成了突出的酶基因 silencing 效率并且减少在 vitro 并且在 vivo 的 Bcl2 蛋白质表示基于西方的污点分析。而且,这 nanogel 在 C57BL/6 老鼠为 B16F10 异种皮移植肿瘤展出了优异反肿瘤活动。这些结果证明联网的 DNG 为基因冷凝作用是有效的并且为肿瘤治疗控制细胞内部的版本。总的来说,这些调查结果建议这多维的可胀大的刺激应答的糊精 nanogel 是有为基因和药交货的大诺言的创新策略。 | Huipeng Li Zhanwei Zhou Feiran Zhang Yuxin Guo Xue Yang Hulin Jiang Fei Tan David Oupicky Minjie Sun | 2018 | Nano Research2018，11，9： | 1 |
| 12 | Application of stress wave theory for pyroshock isolation at spacecraft-rocket interface显示文摘A large number of pyroshock devices are employed in spacecraft and rockets to realize stage separation and appendage deployment.Release of pyroshock devices induces high-level transient shock responses which tend to cause fatal damages in electronic equipment made of crystals and brittle materials.This paper aims to provide methods to isolate pyroshock and guarantee the safety of such equipment against high-frequency shocks.Firstly,stress wave transmission mechanism in stepped rods is investigated,upon which optimal area rate for shock isolation is achieved.Then,two spacecraft-rocket interface structures for pyroshock isolation,namely isolation hole and interim segment,are proposed.Both numerical simulations and experiments are carried out to validate the two shock isolation strategies.It is revealed that the interim segment structure shows better pyroshock isolation performance at the cost of increasing the weight of launching system whereas isolation hole is an optimal choice to reduce pyroshock response without causing weight increase. | Xixiong WANG Tao YU Huipeng YAN Jifeng DING Zhen LI Zhaoye QIN Fulei CHU | 2021 | Chinese Journal of Aeronautics2021，34，8： | 1 |
| 13 | Novel fluorinated polyimides derived from an unsymmetrical diamine containing trifluoromethyl and methyl pendant groups显示文摘 | Wang Chenyi Zhao Huipeng Li Guang | 2010 | Polymers for Advanced Technologies2010，22，12： | 1 |
| 14 | Effects of hy- droxypropyl-β-cyclodextrin and 13-cyclodextrin on the dis- tribution and biodegradation of phenanthren in NAPL-water system显示文摘 | Gao Huipeng Xu Li Cao Yaming | 2013 | International Biodeterioration & Biodegradation2013，83，： | 1 |
| 15 | Identification of con- served and novel microRNAs in cashmere goat skin by deep sequencing 显示文摘 | Zhihong Liu Hongmei Xiao Huipeng Li | 2012 | PLoS One2012，7，50： | 1 |
| 16 | Effect of Temperature on Thermal Treatment of Silica Coated Magnetic Nanoparticles显示文摘 | LI Yu ZHANG Penghong ZHAO Huipeng DU Xiaoqiang LI Junping LIU Laishuan | 2018 | Chemical Research in Chinese Universities2018，34，5： | 0 |
| 17 | Visualization of nasal powder distribution using biomimetic human nasal cavity model显示文摘Nasal drug delivery efficiency is highly dependent on the position in which the drug is deposited in the nasal cavity.However,no reliable method is currently available to assess its impact on delivery performance.In this study,a biomimetic nasal model based on three-dimensional(3D)reconstruction and three-dimensional printing(3DP)technology was developed for visualizing the deposition of drug powders in the nasal cavity.The results showed significant differences in cavity area and volume and powder distribution in the anterior part of the biomimetic nasal model of Chinese males and females.The nasal cavity model was modified with dimethicone and validated to be suitable for the deposition test.The experimental device produced the most satisfactory results with five spray times.Furthermore,particle sizes and spray angles were found to significantly affect the experimental device’s performance and alter drug distribution,respectively.Additionally,mometasone furoate(MF)nasal spray(NS)distribution patterns were investigated in a goat nasal cavity model and three male goat noses,confirming the in vitro and in vivo correlation.In conclusion,the developed human nasal structure biomimetic device has the potential to be a valuable tool for assessing nasal drug delivery system deposition and distribution. | Jiawen Su Yan Liu Hongyu Sun Abid Naeem Huipeng Xu Yue Qu Caifen Wang Zeru Li Jianhua Lu Lulu Wang Xiaofeng Wang Jie Wu Lixin Sun Jiwen Zhang Zhigang Wang Rui Yang Li Wu | 2024 | Acta Pharmaceutica Sinica B2024，14，1： | 0 |
| 18 | Electromagnetic disturbance characteristic of typical high voltage switchgear interruption process in offshore wind farm based on integrated conduction model显示文摘In an offshore wind farm,a high‐voltage switchgear interruption in an offshore substation creates a high‐frequency,high‐amplitude overvoltage that can cause severe electromagnetic interference problems in the intelligent electronic device.To address this issue,mathematical models,vector fitting and finite element method were used to build an integrated electromagnetic disturbance conduction model,whose accuracy was verified by large current interruption tests.Through the simulation of a typical offshore wind farm's single‐phase grounding fault interruption process,the electromagnetic disturbance characteristics and the impact of the ground position are obtained.The results show that during the fault interruption process of phase B grounded,the dominant frequency of disturbance voltage can reach 4.34 MHz,and the amplitude can reach 1.12 kV.The ground grid has a large impact on the interference voltage,which can reach a maximum value of 2.28 kV under specific conditions.The disturbance voltage in the fault process mainly comes through the current transformer,while during the interruption process,it mainly comes through the ground grid.The authors provide a method to establish the integrated electromagnetic disturbance simulation model,which can improve the accuracy of the electromagnetic disturbance conduction process simulation of intelligent components. | Huaqing Wang Daochun Huang Mingjing Shuang Huipeng Li Yiqun Qiu | 2023 | High Voltage2023，8，5： | 0 |
| 19 | Effects of prebiotics on the fermentation of traditional suancai of Northeast China显示文摘Suancai is a traditional fermented vegetable widely consumed in Northeast China.In this study,different prebiotics were used to improve the quality of suancai.Four prebiotics(inulin(INU),xylooligosaccharide(XO S),galactooligosaccharide(GOS),and stachyose(STA))were shown to reduce the pH value and increase the content of total titratable acidity(TTA)in suancai,while the contents of most organic acids were also increased.The addition of prebiotics had significant effects on the bacterial microbiota during the suancai fermentation process.All prebiotics were shown to contribute to the growth of Lactobacillus.The suancai sample with fructooligosaccharides(FOS)had the highest relative abundance of Lactobacillus.Besides,INU and XOS could increase the abundance of Weissella.To evaluate the quality of suancai fermented with prebiotics,profiles of volatile flavor compounds(VOCs)and free amino acids(FAA)were analyzed.The prebiotics affected the VOCs and FAA profiles via transforming the bacterial microbiota.In addition,the addition of prebiotics also changed the taste profiles of the suancai samples.This study is among the first attempts to reveal the effects of different prebiotics on suancai fermentation,and the findings provide a foundation to develop new ways for improving the quality of suancai. | Mingwei Zhao Xinying Cao Yuzheng Wu Sibo Zou Zhigao Li Xinping Lin Chaofan Ji Liang Dong Sufang Zhang Chenxu Yu Huipeng Liang | 2024 | Food Science and Human Wellness2024，13，3： | 0 |
| 20 | Heterogeneous distribution of Cardinium in whitefly populations is associated with host nuclear genetic background显示文摘Inherited bacterial symbionts are very common in arthropods, but infection frequency can vary widely among populations. Experiments and interpopulation comparisons suggest that host genetic background might be important in explaining this variation. Our extensive field investigation showed that the infection pattern of the facultative symbiont Cardinium was heterogeneous across geographical populations of the invasive whitefly Bemisia tabaci Mediterranean (MED) in China, with genetic nuclear differences evident in 2 of the populations: 1 with a low infection rate (SD line) and 1 with a high infection rate (HaN line). However, whether the heterogeneous frequency of Cardinium is associated with the host genetic background remains poorly understood. Here, we compared the fitness of the Cardinium-infected and uninfected sublines with similar nuclear genetic backgrounds from SD and HaN lines, respectively, and further determine whether host extranuclear or nuclear genotype influenced the Cardinium–host phenotype by performing 2 new introgression series of 6 generations between SD and HaN lines (i.e., Cardinium-infected females of SD were backcrossed with uninfected males of HaN, and vice versa). The results showed that Cardinium provides marginal fitness benefits in the SD line, whereas Cardinium provides strong fitness benefits in the HaN line. Further, both Cardinium and the Cardinium–host nuclear interaction influence the fecundity and pre-adult survival rate of B. tabaci, whereas the extranuclear genotype does not. In conclusion, our results provide evidence that Cardinium-mediated fitness effects were closely associated with the host genetic background, which provides a fundamental basis for understanding the mechanism underlying the heterogeneous distribution of Cardinium in B. tabaci MED populations across China. | Hongran Li Ying Liu Xiaoying Wei Huipeng Pan Youjun Zhang Xuguo Zhou Dong Chu | 2023 | Insect Science2023，30，6： | 0 |
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