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| 1 | Nat Chem Biol:利用CRISPR-Cas9激活细菌中沉默的基因簇,有望发现新的药物显示文摘为了抵抗疾病,很多医药库中的武器是从细菌当中获得的。如今,利用CRISPR-Cas9基因编辑技术。研究人员揭示出沉默基因中隐藏着的更多潜在的宝藏。作为一类常见的细菌。链霉菌被用来产生很多作为抗生素、抗癌试剂和其他药物的化合物。在一项新的研究中。来自美国伊利诺伊大学和新加坡科技研究局的研究人员利用CRISPR-Cas9技术激活链霉菌中不表达的或者说沉默的基因簇。 | Mingzi M Zhang, Wan Lin Yeo, Ee Lui Ang, Huimin Zhao Fong Tian Wong, Elena Heng Yajie Wang, Shangwen Luo, Ryan E Cobb, Behnam Enghiad, Huimin Zhao Yee Hwee Lim | 2017 | 现代生物医学进展2017，17，17： | 12 |
| 2 | An ingredient for the elixir of youth显示文摘 | Rebecca E Andersen | 2014 | Cell Research2014，24，12： | 5 |
| 3 | Comparative effectiveness of axitinib versus sorafenib in advanced renal cell carcinoma (AXIS): a randomised phase 3 trial显示文摘 | Brian I Rini Bernard Escudier Piotr Tomczak Andrey Kaprin Cezary Szczylik Thomas E Hutson M Dror Michaelson Vera A Gorbunova Martin E Gore Igor G Rusakov Sylvie Negrier Yen-Chuan Ou Daniel Castellano Ho Yeong Lim Hirotsugu Uemura Jamal Tarazi David Cella | 2011 | The Lancet . 2011 (9807)2011，，9807： | 2 |
| 4 | Comparative effectiveness of axitinib versus sorafenib in advanced renal cell carcinoma (AXIS): a randomised phase 3 trial显示文摘 | Brian I Rini Bernard Escudier Piotr Tomczak Andrey Kaprin Cezary Szczylik Thomas E Hutson M Dror Michaelson Vera A Gorbunova Martin E Gore Igor G Rusakov Sylvie Negrier Yen-Chuan Ou Daniel Castellano Ho Yeong Lim Hirotsugu Uemura Jamal Tarazi David Cella | 2011 | The Lancet2011，，9807： | 2 |
| 5 | The effect of liquid channeling on distillation plate efficiency显示文摘 | Porter K E Lockett M J Lim C T | 1972 | Trans IchemE1972，50，： | 2 |
| 6 | Association of Helicobacter pylori infection with gastric carcinoma: a meta-analysis显示文摘 | Guy D Eslick Lynette L.-Y Lim Julie E Byles Harry H-X Xia Nicholas J Talley | 1999 | The American Journal of Gastroenterology1999，，： | 2 |
| 7 | Evaluation of pi-lot-scale modified A2O processes for the removal of nitrogen compounds from sewage显示文摘 | Lim E T Jeong G T Bhang S H | 2009 | Bioresour Technol2009，100，24： | 1 |
| 8 | Risk of pneumothorax in CT-guided transthoracic needle aspiration biopsy of the lung显示文摘 | KAZEROONI E A LIM F T MIKHAIL A | 1996 | Radiology1996，198，： | 1 |
| 9 | Ferrocement laminates for strengthening RC T- beams 显示文摘 | Paramasivam P Ong K C G Lim C T E | 1994 | Cement and Concrete Composites1994，16，2： | 1 |
| 10 | Instance Based Attribute Identification in Database Integration显示文摘 | ChuaC E H Chiang R H L Lim E P | 2003 | VLDB Journal2003，12，3： | 1 |
| 11 | Comparing Gompertz and Rich- ards functions to estimate freezing injury in Rhododendron using electro- lyte leakage 显示文摘 | LIM C C ARORA R TOWNSEND E D | 1998 | American Society for Horticultural Science1998，123，2： | 1 |
| 12 | Genetic vari- ations in the sodium balance-regulating genes ENaC, NEDD4L, NDFIP2 and USP2 influence blood pres- sure and hypertension显示文摘 | JIN H S HONG K W LIM J E | 2010 | Kidney Blood Press Res2010，33，： | 1 |
| 13 | A comparative study on catalyst deactivation of nickel and cobalt incorporated MCM-41 catalysts modified by platinum in methane reforming with carbon dioxide 显示文摘 | LIU D P CHEO W N E LIM Y W Y BORGN A LAU R YANG Y H | 2010 | Catalysis Today2010，154，34： | 1 |
| 14 | Role of pH-sensitive polymer-liposome complex in enhancing cellular uptake of biologically active drugs显示文摘 | Cho E C Lim H J Kim H J | 2008 | Mater SciEng2008，28，7： | 1 |
| 15 | Acute and long-term safetyevaluation of a novel IH636 grape seed proanthocyanidin extract显示文摘 | Ray S Bagchi D Lim PM e( al | 2001 | Res Commun Mol Pathol Pharmacol2001，109，34： | 1 |
| 16 | Relationship between age and spontaneous ventilation during intravenous anesthesia in children显示文摘 | BARKER N LIM J AMARI E | | 0，，10： | 1 |
| 17 | Monitoring of selected veterinary antibiotics in environmental compartments near a composting facility in Gangwon Province,Korea显示文摘 | Ok Y S Kim S C Kim K R Lee S S Moon D H Lim K J Sung J K Hur S O Yang J E | | 0，，： | 1 |
| 18 | SRS06,a new semi- synthetic andrographolide derivative with improved anticancer potency and selectivity,inhibits nuclear factor -kB nuclear bind ing in the A549 non-small cell lung cancer cell line显示文摘 | Lim J C Jeyaraj E J Sagineedu S R | 2015 | Phar macology2015，95，12： | 1 |
| 19 | The Incidence of Neuro- Ophthalmic Diseases in Singapore: a prospective study in public hospitals 显示文摘 | Lim SA Wong WL Fu E | 2009 | Ophthalmic Epidemiol2009，2，： | 1 |
| 20 | High mobility InGaZnO4 thin-film transistors on paper 显示文摘 | LIM W DOUGLAS E A KIM S H | 2009 | Applied Physics Letters2009，94，7： | 1 |
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