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| 1 | Ly49 receptors activate angiogenic mouse DBA+ uterine natural killer cells显示文摘 | Patricia DA Lima Megan M Tu Mir Munir A Rahim Annie R Peng B Anne Croy Andrew P Makrigiannis | 2014 | Cellular & Molecular Immunology2014，11，5： | 3 |
| 2 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 3 | Tunable frequency selective surfaces using liquid substrates显示文摘 | Lima A C C Parker E A Langley R J | 1994 | Electronics Letters1994，30，4： | 1 |
| 4 | Regulation of hemolymph osmolytes and gill Na^+/K^+-ATPase activities during acclimation to saline in the freshwater shrimp Macrobrachium olfersii(Wiegmann,1836)(Decapoda,Palaemonidae)显示文摘 | Lima A G McNamara J C Terra W R | 1997 | J Exp Mar Biol Ecol1997，215，： | 1 |
| 5 | Anionic flotation of railings of manganese ore 显示文摘 | Lima R M F Vasconcelos J A da Silva G R | 2008 | Rem-revista Escolade Minas2008，61，3： | 1 |
| 6 | First-time report of metalloproteinases in fish bile and their po- tential as bioindicators regarding environmental contamination 显示文摘 | HAUSER-DAVIS R A LIMA A A ZIOLLI R L | 2012 | Aquatic Toxicol2012，，110111： | 1 |
| 7 | Neurohumoral features of myocardial stunning due to sudden emotional stress 显示文摘 | Wittstein I S Thiemann D R Lima J A | 2005 | N Engl J Med2005，352，6： | 1 |
| 8 | Population dynamics of rice rats (a Hantavirus reservoir) in southern Chile: feedback structure and non-linear effects of climatic oscillations显示文摘 | Murua R Gonzalez L A Lima M | 2003 | Oikos2003，102，11： | 1 |
| 9 | Prevalence and nonrandom distribution of exonic mutations in inter-feron regulatory factor 6 in 307 families with Van der Woude syndrome and 37 families with popliteal pterygium syndrome显示文摘 | de LIMA R L HOPER S A GHASSIBE M | 2009 | Genet Med2009，11，： | 1 |
| 10 | Myocardial Gd-DTPA kinetics determine MRI contrast enhancement and reflect the extent and severity of myocardial injury after acute reperfused infarction显示文摘 | Kim R J Chen E L Lima J A | 1996 | Circulation1996，94，12： | 1 |
| 11 | Evaluation of microhardness and elastic modulus of thermally sprayed nanostructured zirconia coatings 显示文摘 | Lima R S Kucuk A Berndt C C | 2001 | Surface and Coatings Technology2001，135，2： | 1 |
| 12 | Integrity of nanostructured partially stabilized zirconia after plasma spray processing显示文摘 | Lima R S Kucuk A Berndt C C | 2001 | Materials Science and Engineering A2001，313，： | 1 |
| 13 | Efficacy of low--level laser therapy and aluminum hydroxide in pa- tients with chemotherapy and radiotherapy-induced oral mucositis显示文摘 | Lima A G Antequera R Peres M P | 2010 | Braz Dent J2010，21，3： | 1 |
| 14 | Heat storage rate and acute fatigue in rats显示文摘 | Rodrigues L O Oliveira A Lima N R | 2003 | Braz J Med Biol Res2003，36，1： | 1 |
| 15 | Assessing therapeutic responsesin Kras mutant cancers using genetically engineerred mouse mod-els显示文摘 | Singh M Lima A Molina R | 2010 | Nat Biotechnol2010，28，6： | 1 |
| 16 | Particle filter with differential evolution for trajecttry tracking 显示文摘 | DE LIMA L M KROHLING R A | 2011 | Advances in Intelligent and Soft Computing2011，96，1： | 1 |
| 17 | Development of a DNA-based vaccine strategy against bovine papil- lomavirus infection,involving the E5 or L2 gene显示文摘 | Lima E G Lira R C Jesus A L S | 2014 | Genet Mol Res2014，13，1： | 1 |
| 18 | Prebiotic and diet/light chocolate dairy dessert:Chemical composition,sensory profiling and relationship with consumer expectation显示文摘 | De MORAIS E C LIMA G C De MORAIS A R | 2015 | LWT-Food Science and Technology2015，62，1： | 1 |
| 19 | Neurohumoral features of myocardial stunning due to sudden emotional stress显示文摘 | WITTSTEIN I S THIEMANN D R LIMA J A C | 2005 | N Engl J Med2005，352，： | 1 |
| 20 | Nuclear magnetic resonance and water activity in measuring the water mobility in Pintado (Pseudoplatystoma corruscans) fish显示文摘 | P1TOMBO R N M LIMA G A M R | 2003 | Journal of Food Engineering2003，58，1： | 1 |
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