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| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | Photochemical responses and oxidative stress in the clones of Coffea canephora under water deficit conditions显示文摘 | Lima A L S DaMatta F M Pinheiro H A | 2002 | Environmental and Experimental Botany2002，47，23： | 1 |
| 3 | Photochemical responses and oxidative stress in two clones of Coffea canephora under water deficit conditions显示文摘 | LIMA A L S DAMATT F M PINHEIRO H A | 2002 | Environmental and Experimental Botany2002，47，： | 1 |
| 4 | ln vivo and in vitro studies on the anticancer activity of Copaifera multijuga Hayne and its fractions显示文摘 | Lima S R M Junior V F V Christo H B | 2003 | Phytotherapy Research2003，17，9： | 1 |
| 5 | A new Fusarium lineage within the Gibberellafujikuroi species complex is the main causal agent of mango malformation disease in Brazil显示文摘 | LIMA C S PFENNING L H COSTA S S CAMPOS M A LESLIE J F | 2009 | Plant Pathology2009，58，： | 1 |
| 6 | Microstructural an- alyses and wear behavior of the cemented carbide tools after laser surface treatment and PVD coating 显示文摘 | Neves D Diniz A E Lima M S F | 2013 | Ap- plied Surface Science2013，282，： | 1 |
| 7 | Effect of source of supplemental selenium on uterine health and embryo quality in high-producing dairy cows显示文摘 | Cerri R L A Rutigliano H M Lima F S | 2009 | Theriogenology2009，71，7： | 1 |
| 8 | Microstructure and surface properties of laser-remelted titanium nitride coatings on titanium显示文摘 | Lima M S F Foliob F Mischler S | 2005 | Surface & Coatings Technology2005，199，： | 1 |
| 9 | Luminescent properties and lattice defects correlation on zinc oxide显示文摘 | Lima S A M Sigoli F A Jafelicci M | 2001 | International Journal of Inorganic Materials2001，，3： | 1 |
| 10 | Microstructure and surface properties of laser-remelted titanium nitride coatings on titanium显示文摘 | Lima M S F Folio F Mischler S | 2005 | Surface and Coatings Technology2005，199，1： | 1 |
| 11 | Liquid - liquid extraction of proteases from fermented broth by PEG/citrate aqueous two-phase system 显示文摘 | Porto T S Silva G M M Porto C S Cavalcanti M T H Neto B B Lima F J L Converti A Porto A L F Pessoa J A | 2008 | Chemical Engineering and Processing2008，47，4： | 1 |
| 12 | Population structure and reproductive dynamics of Octopus insularis (Cephalopoda: Octopodidae) in a coastal reef environment along northeastern Brazil 显示文摘 | LIMA F D LEITE T S HAIMOVICI M | 2014 | Fisheries Research2014，，152： | 1 |
| 13 | Biodegradation of p-chlorophenol by a microalgae consortium 显示文摘 | Lima S A C Raposo M F J | 2004 | Water Research2004，38，1： | 1 |
| 14 | Sexually transmitted infections in a female population in rural northeast Brazil:prevalence morbidity and risk factors显示文摘 | Lima S V Mesquita A M Cavalcante F G | 2003 | Trop Med Int Health2003，8，7： | 1 |
| 15 | Luminescent Properties and Lattice Defects Correlation on Zinc Oxide显示文摘 | Lima S A M Sigoli F A Jafelicci M | 2001 | lnternatiorcal Journal of Inorganic Materials2001，，3： | 1 |
| 16 | 查看详情显示文摘 | Lima A M F de Castro V G Borges R S Silva G G | | 0，，02： | 1 |
| 17 | Luminescent properties and lattice defects correlation on zinc oxide显示文摘 | Lima S A M Sigoli F A Jafelicei M et d | 2001 | International Journal of Inorganic Materials2001，3，7： | 1 |
| 18 | Dipylidium caninum ( Cyclophyllidea, Dipylidiidae) in a wild carnivore from Brazil 显示文摘 | Vieira F M Luque J L Lima Sde S | 2012 | J Witdl Dis2012，48，1： | 1 |
| 19 | Unexpected transition from single to double quantum well potential induced by intense laser fields in a semiconductor quantum well显示文摘 | Lima F M S Amato M A Nunes O A C | 2009 | J Appl Phys2009，105，12： | 1 |
| 20 | Magnetic field effect on the laser-driven density of states for electrons in a cylindrical quantum wire:transition from one-dimensional to zero-dimensional behavior显示文摘 | Lima C P Lima F M S Fonseca A L A | 2011 | New J Phys2011，13，07： | 1 |
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