|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Colonic ulcerations may predict steroid-refractory course in patients with ipilimumab-mediated enterocolitis显示文摘AIM To investigate management of patients who develop ipilimumab-mediated enterocolitis, including association of endoscopic findings with steroid-refractory symptoms and utility of infliximab as second-line therapy.METHODS We retrospectively reviewed all patients at our centerwith metastatic melanoma who were treated with ipilimumab between March 2011 and May 2014. All patients received a standard regimen of intravenous ipilimumab 3 mg/kg every 3 wk for four doses or until therapy was stopped due to toxicity or disease progression. Basic demographic and clinical data were collected on all patients. For patients who developed grade 2 or worse diarrhea(increase of 4 bowel movements per day), additional data were collected regarding details of gastrointestinal symptoms, endoscopic findings and treatment course. Descriptive statistics were used.RESULTS A total of 114 patients were treated with ipilimumab during the study period and all were included. Sixteen patients(14%) developed ≥ grade 2 diarrhea. All patients were treated with high-dose corticosteroids(1-2 mg/kg prednisone daily or equivalent). Nine of 16 patients(56%) had ongoing diarrhea despite highdose steroids. Steroid-refractory patients received one dose of intravenous infliximab at 5 mg/kg, and all but one had brisk resolution of diarrhea. Fourteen of the patients underwent either colonoscopy or sigmoidoscopy with variable endoscopic findings, ranging from mild erythema to colonic ulcers. Among 8 patients with ulcers demonstrated by sigmoidoscopy or colonoscopy, 7 patients(88%) developed steroidrefractory symptoms requiring infliximab. With a median follow-up of 264 d, no major adverse events associated with prednisone or infliximab were reported.CONCLUSION In patients with ipilimumab-mediated enterocolitis, the presence of colonic ulcers on endoscopy was associated with a steroid-refractory course. | Animesh Jain Evan J Lipson William H Sharfman Steven R Brant Mark G Lazarev | 2017 | World Journal of Gastroenterology2017，23，11： | 8 |
| 2 | Automated reverse engineering of nonlinear dynamical systems显示文摘 | BONGARD J LIPSON H | | 0，，： | 1 |
| 3 | Optimization-basod reconstruction of a 3D object from a single freehand line drawing显示文摘 | Lipson H Shpitalni M | 1996 | Computer Aided Design1996，28，8： | 1 |
| 4 | Elements of X-ray diffraction显示文摘 | Lipson H | 1979 | Contemporary Phys1979，20，1： | 1 |
| 5 | Automatic design and manufacture of robotic lifeforms显示文摘 | Lipson H Jordan B P | 2000 | Nature2000，8，4： | 1 |
| 6 | 1980 Volvo award in basic science:proteoglycans in experimental intervertebral disc degeneration显示文摘 | LIPSON S J MUIR H | 1981 | Spine1981，6，： | 1 |
| 7 | Experimental interveflebral disc degeneration: morphologic and proteoglycon changes over- time显示文摘 | Lipson SJ Muir H | 1981 | Arthritis Rheum1981，24，1： | 1 |
| 8 | Optimization-based reconstruction of a 3D object from a single freehand line drawing 显示文摘 | Lipson H Shpitalni M | 1996 | Computer-Aided Design1996，28，8： | 1 |
| 9 | Optimization-based reconstruction of a 3D object from a single freehand line drawing 显示文摘 | Lipson H Shpitalni M | 1996 | Computer-Aided Design1996，25，8： | 1 |
| 10 | Optimization-based reconstruction of a 3D object from a single freehand line drawing显示文摘 | Lipson H Shpitalni M | 1996 | Journal of Computer Aided Design1996，28，8： | 1 |
| 11 | Optimization-based reconstruction of a 3D object from a single freehand line drawing显示文摘 | Lipson H Shpitalni M | 1996 | Computer-Aided Design1996，28，8： | 1 |
| 12 | Classification of sketch strokes and corner detection using conic sections and adaptive clustering显示文摘 | Shpitalni M Lipson H | 1997 | Transactions of ASME Journal of Mechanical Design1997，119，2： | 1 |
| 13 | Distilling free form natural laws from experimental data 显示文摘 | Schmidt M Lipson H | 2009 | Science2009，324，： | 1 |
| 14 | Distilling Free-form Natural Laws from Experimental Data显示文摘 | Schmidt M and Lipson H | 2009 | Science2009，324，5923： | 1 |
| 15 | Measurement of Gas in Molten Aluminum显示文摘 | Rosenthal H Lipson S | 1995 | AFS Trans1995，，63： | 1 |
| 16 | New world of 3-D printing offers 'completely new ways of thinking': Q&A with author, engineer, and 3-D printing expert Hod Lipson显示文摘 | Lipson H | 2013 | IEEE Pulse2013，4，6： | 1 |
| 17 | Proteoglycans in experimental intervede- bral disc degeneration显示文摘 | Lipson SJ Muir H | 1981 | Spine1981，6，3： | 1 |
| 18 | Classification of sketch strokes and corner detection using conic sections and adaptive clustering 显示文摘 | Shpitalni M Lipson H | 1997 | Transactions of the ASME Journal of Mechanical Design1997，119，1： | 1 |
| 19 | Associations between Spinal Deformity and Outcomes after Decompression for Spinal Stenosis显示文摘 | Frazier D D Lipson S J Fossel A H | 1997 | Spine1997，22，17： | 1 |
| 20 | Durable cancer regression off-treatment and effective reinduction therapy with an anti-PD-1 antibody显示文摘 | Lipson E J Shaffman W H Drake C G | 2013 | Clin Cancer Res2013，19，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员