|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Platelet-rich plasma increases transforming growth factor-beta1 expression at graft-host interface following autologous osteochondral transplantation in a rabbit model显示文摘AIM: To explore the effect of platelet-rich plasma on protein expression patterns of transforming growth factor-beta1(TGF-β1) in cartilage following autologous osteochondral transplantation(AOT) in a rabbit knee cartilage defect model.METHODS: Twelve New Zealand white rabbits received bilateral AOT. In each rabbit, one knee was randomized to receive an autologous platelet rich plasma(PRP) injection and the contralateral knee received saline injection. Rabbits were euthanized at 3, 6 and 12 wk post-operatively. Articular cartilage sections were stained with TGF-β1 antibody. Histological regions of interest(ROI)(left, right and center of the autologous grafts interfaces) were evaluated using Meta Morph. Percentage of chondrocytes positive for TGF-β1 was then assessed.RESULTS: Percentage of chondrocytes positive for TGF-β1 was higher in PRP treated knees for selected ROIs(left; P = 0.03, center; P = 0.05) compared to control and was also higher in the PRP group at each post-operative time point(P = 6.6 × 10^(-4), 3.1 × 10^(-4) and 7.3 × 10^(-3) for 3, 6 and 12 wk, respectively). TGF-β1 expression was higher in chondrocytes of PRP-treated knees(36% ± 29% vs 15% ± 18%)(P = 1.8 × 10^(-6)) overall for each post-operative time point and ROI. CONCLUSION: Articular cartilage of rabbits treated with AOT and PRP exhibit increased TGF-β1 expression compared to those treated with AOT and saline. Our findings suggest that adjunctive PRP may increase TGF-β1 expression, which may play a role in the chondrogenic effect of PRP in vivo. | Lorraine A Boakye Keir A Ross John M Pinski Niall A Smyth Amgad M Haleem Charles P Hannon Lisa A Fortier John G Kennedy | 2015 | World Journal of Orthopedics2015，6，11： | 7 |
| 2 | 一种房颤风险评分系统的建立(Framingham心脏研究):基于社区的队列研究显示文摘背景房颤导致了发病率和病死率的显著上升。本研究旨在建立一种预测个体罹患房颤绝对风险的风险评分系统,并提供研究人员评价新危险因素的流程。方法作者评估了Framingham心脏研究中于1968年6月至1987年9月间进行了8044次检测的4764例参与者(55%为女性,年龄45~95岁)。此后,参与者被随访至房颤首发,随访期最长达10年。多变量Coxi回归确认出1(1年内罹患房颤的临床危险因素。次级分析纳入了常规超声心动图检测指标(5152例4参与者,7156次检测)对房颤风险进行再分层评估,并评价超声检测指标能否提高风险预测能力。结果4764例参与者中的457例4(10%)罹患房颤。年龄、性别、体重指数、收缩压、降压治疗、PR间期、有临床意义的心脏杂音及心力衰竭与房颤相关,并被纳入了风险评分模型(除体重指数P=0.08外,其余均为P〈0.05),模型的C统计量为0.78(95%CI0.76~0.80)。10年房颤风险随年龄变化:年龄〈65岁的人群中53例(1%)风险高于15%,而〉65岁的人群中为783例(27%)。为提高预测能力而纳入超声检测指标仅使模型C统计量略微增高,由0.78(95%C10.75~0.80)增至0.79(95%CI0.77~0.82:P=0.005)。超声心动图检测指标并不能改善风险再分层评估(P=0.18)。结论基于社区医疗中易得的临床因素建立的风险评分系统,有助于确认社区个体罹患房颤的风险,评估技术或标志物能否改善风险预测,以及针对高危个体采取预防措施。 | Renate B Schnabel Lisa M Sullivan Daniel Levy Michael J Pencina Joseph M Massaro Ralph B D'Agostino Sr Christopher Newton-Cheh Jennifer F Yamamoto Jared W Magnani Thomas M Tadros William B Kannel Thomas J Wang Patrick T Ellinor Philip A Wolf Ramachanclran S Vasan Emelia J Benjamin 黄刚(译) | 2009 | 世界临床医学2009，，9： | 2 |
| 3 | Perspectives on the clinical development of mmunotherapy in prostate cancer显示文摘 | Lisa M Cordes James L Gulley Ravi A Madan | 2018 | Asian Journal of Andrology2018，20，3： | 2 |
| 4 | Differential expression of components of the cardiomyocyte adrenomedullin/intermedin receptor system following blood pressure red-uction in Nodeificient hypertension显示文摘 | Abdelrahman A M David B Lisa R S | 2005 | JPET Fast Forward2005，12，3： | 1 |
| 5 | The effects of trust and interde pendenee on relationship commitment: A trans-Athantie study 显示文摘 | INGE GEYSKENSA JAN-BENEDICT E M STEENKAMPB A LISA K SCHEERC | 1996 | Int J Res Marketing1996，13，4： | 1 |
| 6 | Determination of the oxidation states of manganese in brain, liver, and heart mitochondria 显示文摘 | Thomas E G Lisa M M Claire E G Roman E Jason S Linas B Andrei A Sean H Karlene K G | 2004 | Journal of Neuroehemistry2004，88，： | 1 |
| 7 | Knowledge Organization in Research: A Conceptual Model for Organizing data 显示文摘 | Lisa M Given Hope A Olson | 2003 | Library & Information Science Reserch2003，，25： | 1 |
| 8 | Computational and experimental study of axisymmetric coflow partially premixed methane/air flames显示文摘 | Beth A V B Charles S M Lisa D P | 2000 | Combustion and Flame2000，123，4： | 1 |
| 9 | Whole blood optical biosensor 显示文摘 | Lisa M B Lisa A D | 2007 | Biosensors and Bioelectronics2007，23，3： | 1 |
| 10 | Severe recurrent ureteral stricture: the combined use of an anterograde and retrograde approach in the prone split-leg position without X-rays显示文摘 | Cossu F M De Lisa A | 1997 | Eur Urol1997，31，2： | 1 |
| 11 | Autologous fat grafting improves facial nerve function显示文摘 | Klinger M Lisa A Caviggioli F | 2015 | Case Rep Surg2015，2015，52： | 1 |
| 12 | Effect of interferon gamma-1b on survival in patients with idiopathic pulmonary fibrosis (INSPIRE): a multicentre, randomised, placebo-controlled trial显示文摘 | Talmadge E King Carlo Albera Williamson Z Bradford Ulrich Costabel Phil Hormel Lisa Lancaster Paul W Noble Steven A Sahn Javier Szwarcberg Michiel Thomeer Dominique Valeyre Roland M du Bois | 2009 | The Lancet . 2009 (9685)2009，，： | 1 |
| 13 | Colonization, succession, and nutrition of macrobenthic assemblages in a restored wetland at Tijuana Estuary, California显示文摘 | Serena M M Lisa A L Carolyn C | 2004 | Estuary Coast & Shelf Science2004，60，： | 1 |
| 14 | TUNEL-positive ganglion cells in human primary open-angle glaucoma显示文摘 | LISA A K KERRIGAN M S | 1997 | Arch Ophthalmol1997，115，8： | 1 |
| 15 | The adjuvant effects of Mycobacterium tuberculosis heat shock protein 70 result form the rapid and prolonged activation of antigen-specific CD8+T cells in vivo显示文摘 | Elizabeth G I Julie M C | 2002 | J Immunol2002，169，： | 1 |
| 16 | Cloning,Expression,and type Ⅱ collagenolytic activity of matrix metalloproteinase -13 from human osteoarthritic cartilage显示文摘 | Peter GM itchell Holly A Magna Lisa M Reeves | 1996 | J Clin Invest1996，97，3： | 1 |
| 17 | Characterization of non- methane hydrocarbons in the rural southeast United States显示文摘 | Hagerman Lisa M Aneja Viney P Lonneman William A | 1997 | Atmospheric environment1997，31，： | 1 |
| 18 | The clinical research office of the endourological society percutaneous nephrolithotomy global study: staghorn versus nonstaghorn stones 显示文摘 | Desai M De Lisa A Turna B | 2011 | J Endourol2011，25，8： | 1 |
| 19 | A Qualitative Study of Potential Suicide Risk Factors in Returning Combat Veterans显示文摘 | Brenner Lisa A Gutierrez Peter M Cornette Michelle M Betthauser Lisa M Bahraini Nazanin Staves Pamela J | 2008 | Journal of Mental Health Counseling2008，，： | 1 |
| 20 | Nanoindentafion of biological materials显示文摘 | Donna M Ebenstem Lisa A Pruitt | 2006 | Nanotoday2006，1，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员