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| 1 | 与HBeAg阴性慢性乙型肝炎患者成功停药相关的病毒和免疫因素显示文摘【据Journal of Hepatology 2020年12月报道】与HBeAg阴性慢性乙型肝炎患者成功停药相关的病毒和免疫因素(作者García-López M等)目前,与HBeAg阴性慢性乙型肝炎(CHB)患者成功停用核苷(酸)类似物(NA)治疗的相关因素尚未阐明。为了分析停用NA患者的HBV特异性T淋巴细胞反应以及外周和肝内病毒参数,来自西班牙巴塞罗那大学的García-López等对27例病毒完全抑制(>3年)HBeAg阴性CHB非肝硬化患者进行了前瞻性研究。在基线时定量检测肝内HBV DNA(iHBV DNA)、肝内HBV RNA(iHBV RNA)和共价闭合环状DNA(cccDNA)。此外,在基线和整个随访过程中,对血清标志物(HBV DNA、HBsAg、HBcrAg和HBV RNA)和HBV特异性T淋巴细胞反应进行了分析。 | GARCIA-LOPEZ M LENS S PALLETT LJ 孟方园 高沿航 | 2021 | 临床肝胆病杂志2021，37，2： | 8 |
| 2 | 钠摄入量与血压的关系随能量摄入而变化:终止高血压膳食研究-钠试验的二次分析显示文摘膳食钠的摄入量是以绝对量(mg/d)表示而不是以钠密度(mg/kcal)表示的。研究者旨在确定钠摄入量与血压关系的强弱是否随着能量摄入量而变化。终止高血压膳食研究(dietary approaches to stop hypertension,DASH)-钠试验是比较2种膳食(DASH和对照)和3种钠密度水平的随机膳食摄入试验。 | 刘青 叶鹏 Murtaugh MA Beasley JM Appel LJ Guenther PM McFadden M Greene T Tooze JA | 2018 | 中华高血压杂志2018，26，6： | 7 |
| 3 | Colonoscopic yield of colorectal neoplasia in daily clinical practice显示文摘AIM:To assess the prevalence and location of ad-vanced neoplasia in patients undergoing colonoscopy,and to compare the yield per indication.METHODS:In a multicenter colonoscopy survey (n = 18 hospitals) in the Amsterdam area (Northern Holland),data of all colonoscopies performed during a three month period in 2005 were analyzed. The location and the histological features of all colonic neoplasia were recorded. The prevalence and the distribution ofadvanced colorectal neoplasia and differences in yield between indication clusters were evaluated. Advanced neoplasm was defi ned as adenoma > 10 mm in size,with > 25% villous features or with high-grade dyspla-sia or cancer.RESULTS:A total of 4623 eligible patients underwent a total colonoscopy. The prevalence of advanced neo-plasia was 13%,with 281 (6%) adenocarcinomas and 342 (7%) advanced adenomas. Sixty-seven percent and 33% of advanced neoplasia were located in the distal and proximal colon,respectively. Of all patients with right-sided advanced neoplasia (n = 228),51% had a normal distal colon,whereas 27% had a syn-chronous distal adenoma. Ten percent of all colono-scopies were performed in asymptomatic patients,7% of whom had advanced neoplasia. In the respective procedure indication clusters,the prevalence of right-sided advanced neoplasia ranged from 11%-57%. CONCLUSION:One out of every 7-8 colonoscopies yielded an advanced colorectal neoplasm. Colonoscopy is warranted for the evaluation of both symptomatic and asymptomatic patients. | Jochim S Terhaar sive Droste Mike E Craanen Rene WM van der Hulst Joep F Bartelsman Dick P Bezemer Kim R Cappendijk Gerrit A Meijer Linde M Morsink Pleun Snel Hans ARE Tuynman Roy LJ van Wanrooy Eric IC Wesdorp Chris JJ Mulder | 2009 | World Journal of Gastroenterology2009，15，9： | 6 |
| 4 | Small interfering RNA inhibits SARS-CoV nucleocapsid gene expression in cultured cells and mouse muscles显示文摘 | Zhao P Qin ZL Ke JS Lu Y Liu M Pan W Zhao LJ Cao J Qi ZT | 2005 | 第二军医大学学报2005，26，10： | 4 |
| 5 | 冠状动脉钙化在高血压患者心血管病风险分层中的作用显示文摘研究者研究了冠状动脉钙化(coronary artery calcium,CAC)在成人高血压心血管病风险分层中的作用,包括符合收缩压干预试验(systolic blood pressure intervention trial,SPRINT)标准的患者。此外,研究者使用CAC来确定心血管病死亡率与SPRINT中标准降压组心血管病死亡率('SPRINT水平')相当的高血压成年患者,其可能受益于强化降压治疗。研究人群包括来自CAC研究联盟的高血压患者16 167例,其中6375例患者构成'SPRINT类似人群'。研究者按CAC分类(0,1~99,100~399,≥400)比较了多因素校正后的冠状动脉粥样硬化性心脏病(冠心病)和心血管病死亡风险比。 | 刘青(译) 叶鹏(摘、审校) Uddin SMI Mirbolouk M Kianoush S Orimoloye OA Dardari Z Whelton SP Miedema MD Nasir K Rumberger JA Shaw LJ Berman DS Budoff MJ McEvoy JW Matsushita K Blaha MJ Graham G | 2019 | 中华高血压杂志2019，27，5： | 3 |
| 6 | 体位性低血压的危险因素:老年男女存在差异显示文摘体位性低血压(orthostatic hypotension,OH)一般发生在站立后调节血压水平的机制发生变化以后。目前尚不清楚不同性别间OH的发生率和危险因素有何不同。本文旨在调查老年人OH患病率和危险因素的性别差异。方法:纳入来自委内瑞拉马拉开波老龄化研究的882名参与者。从仰卧位到站立位3 min后,收缩压持续下降≥20和(或)舒张压持续下降≥10 mm Hg(1 mm Hg=0.133 kPa)定义为OH。考虑到性别的交互作用和性别分层,研究者采用多因素Logistic回归模型评估男、女OH危险因素的相关性。 | Méndez AS Melgarejo JD Mena LJ Chávez CA González AC Boggia J Terwilliger JD Lee JH Maestre GE 陈云 叶鹏 | 2019 | 中华高血压杂志2019，27，6： | 2 |
| 7 | Fractures attributable to osteoporosis:report from the National Osteoporosis Foundation显示文摘 | Melton LJ 3rd Thamer M Ray NF | 1997 | J Bone Miner Res1997，12，1： | 1 |
| 8 | Role of magnesium in insulin action, diabetes and cardio-metabolic syndrome X 显示文摘 | Barbagullo M Dominguez LJ Galioto A | 2003 | J Mol Asp Med2003，24，13： | 1 |
| 9 | State-of-the-art review of pulmonary fungal infections显示文摘 | Goldman M Sarosi G | 2002 | Semin Respir Infect2002，17，2： | 1 |
| 10 | Role of the PLDLS-binding cleft region of CtBP1 in recruitment of core and auxiliary components of the corepressor complex显示文摘 | Kuppuswamy M Vijayalingam S Zhao LJ | 2008 | Mol Cell Biol2008，28，1： | 1 |
| 11 | Rat Strains Differ in Susceptibility to Urinary Tract Infection and Struvite Ureaplasma parvum-Induced Urinary Tract Infection and Struvite Stone Formation显示文摘 | Reyes L Reinhard M O'Donell LJ | 2006 | Infection and immunity2006，74，12： | 1 |
| 12 | Impact of sodium and uhrafihration profiling on hemodialysis- related symptoms 显示文摘 | Oliver M J Edwards LJ Churchill DN | 2001 | J Am Soc Nephrol2001，12，1： | 1 |
| 13 | The influence of the refrigerant charge on the function of small refrigeration appliances 显示文摘 | Kuijpers LJ M Janssen M J P | 1988 | ASHRAE Transactions1988，94，2： | 1 |
| 14 | Identification of a novel arabinofuranosyltransferase(AftA) involved in cell wall arabinan biosynthesis in Mycobacterium tuberculosis 显示文摘 | Alderwick LJ Seidel M Sahm H | 2006 | J Biol Chem2006，281，23： | 1 |
| 15 | Plasma resist in concertration hepatic fat content,and hepatic and peripheral insulin resistance in pioglitazonetreated type diabetic patients显示文摘 | Bajaj M Suraamomkul S Hardies LJ | 2004 | Int J Obes Relat Metab Disord2004，28，6： | 1 |
| 16 | Requirement for nitric oxide activation of p21 (ras) / extracellular egulated kinase in neuronal ischemic preconditioning 显示文摘 | Gonzalez - Zulueta M Feldman AB Klesse LJ | 2000 | Proc Natl Acad Sci USA2000，97，1： | 1 |
| 17 | A proprietary extract from North American ginseng(Panax quinquefolium) enhances IL-2 and IFN-γ productions in murine spleen ceils induced by Con-A显示文摘 | Wang M Guilbert LJ Li J | 2004 | International Immunopharmacology2004，4，2： | 1 |
| 18 | Genome instabil- ity is increased in lymphocytes of women with polycystic ovary syndrome and is correlated with insulin resistance 显示文摘 | MORAN LJ NOAKES M CLIFTON PM | 2008 | Mutat Res2008，639，12： | 1 |
| 19 | Design of laser interferometric system for measurement of gear tooth flank显示文摘 | Fang SP Wang LJ Komori M | | 0，，14： | 1 |
| 20 | Grassland responses to grazing:effects of grazing intensity and management system in an Inner Mongolian steppe ecosystem显示文摘 | Sch(o)nbach P Wan HW Gierus M Bai YF Müller K Lin LJ Susenbeth A Taube F | | 0，，： | 1 |
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