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1502篇 您的检索式:作者名="LLOYD J"
    题名 作者 年代 出处 被引量
1多种癌-睾丸抗原基因在术前化疗非小细胞肺癌中的表达显示文摘目的 研究癌 睾丸抗原 (CT)抗原在经术前化疗的非小细胞肺癌 (NSCLC)中的表达谱 ,以确定NSCLC经化疗、手术后可能的辅助免疫治疗疫苗治疗组成成分。方法 用逆转录 聚合酶链反应 (RT PCR)检测了 5 1例经化疗后手术的原发性NSCLC病人肿瘤组织中 11种CT抗原基因的表达情况。结果 所检测的 11种CT基因在经化疗后的NSCLC表达最高的为MAGE 3,38% ,其次分别为NY ESO 12 1% ,CT10 17% ,LAGE 115 % ,MAGE 4 13% ,SCP 1、SSX1、SSX4均为 12 % ,MAGE 110 % ,SSX2 6 % ,CT72 %。在这些病人中 ,有 34例 (6 7% )病人表达至少 1种CT基因。在不表达所检测的任何CT基因的 17例病人中 ,13例 (76 % )为Ⅰ期病人。MAGE 3和CT10在NSCLC中表现出了随疾病进展而增加的现象 ;反之 ,SCP 1的表达主要在Ⅰ期和Ⅱ期。将NSCLC经病理分类分为鳞癌和腺癌 ,发现鳞癌中至少表达 1种CT基因 (75 % )和共表达CT基因的频率 (5 5 % )均比腺癌 (5 3%和 2 4 % )高。结论 (1)包括MAGE 3、NY ESO 1、LAGE 1等抗原成分的CT抗原疫苗可应用于术前化疗的NSCLC病人的治疗 ;(2 )对不同NSCLC肿瘤分期的病人可采取不同CT抗原成分疫苗 ;(3)对晚期手术和化疗疗效不好的病人和鳞癌病人 ,CT抗原疫苗治疗是一个值得研究的重要方向。王歈 梁震 袁艳华 韩燕 刘月香 刘年 Yao-Tseng Chen Gerd Ritter Lloyd J Old 张力建 2004中华医学杂志2004,84,6:4
2高危心血管病老年人血压变异性的相关因素显示文摘诊问血压变异性是心血管病的独立预测因素。该研究探讨老年人血压变异的相关因素。方法:在普伐他汀干预高危老年人的前瞻性研究( pravastatin inelderly individuals at risk of vascular disease, PROS-PER)中,分析70~82岁有心血管病史或危险因素的男性和女性者3794人。Poortvliet RK Lloyd SM Ford I Sattar N de Craen AJ Wijsman LW Mooijaart SP Westendorp G Jukema JW de Ruijter W Gussekloo J Stott DJ 2015中华高血压杂志2015,23,10:3
3On pre-straining and the evolution of material anisotropy in sheet metals显示文摘WU P D MACEWEN S R LLOYD D J JAIN M TUGCU P NEALE K W 2005Int J Plasticity2005,21,:1
4Effects on biliary tract pressure in humans of intravenous ketorolae tromethamine compared with morphine and placebo显示文摘Krimmer H Bullingharn RE Lloyd J 1992Anesth Analg1992,75,2:1
5Characterization of the evolution of the volume fi:action of precipitates in aged AlMgSiCu alloys using DSC technique显示文摘Esmaeili S Lloyd D J 2005Materials Characterization2005,55,45:1
6Mold performance of some constructiori products with and without borates显示文摘Fogel J L Lloyd J D 2002Forest Products Journa12002,52,2:1
7The dehydration of the lower fatty acids by extractive distillation 显示文摘LLOYD B SZABADOS R J WENDT K M 1990Chem Eng Commun1990,89,1:1
8On the temperature dependence of soil respiration 显示文摘Lloyd J & Taylor J A 1994Functional Ecology1994,8,3:1
9The Role of Leisure in Determining Quality of Life: Issues of Content and Measurement 显示文摘Kathleen M Lloyd Christopher J Auld 2002Social Indicators Research2002,,57:1
10Sacral resection and reconstruction for tumors and tumor-like conditions 显示文摘Randall RL Bruckner J Lloyd C 2005Orthopedics2005,28,3:1
11ON the temperature-dependence of soil respiration显示文摘Lloyd J Taylor J A 1994Functional Ecology1994,8,3:1
12The empirical measurement of intra-industry trade显示文摘Grubel H G Lloyd P J 1971Economic Record1971,,12:1
13Acute and chronic pancreatitis-diseases on the rise: a study of hospital admissions in England 1989/90-1999/2000显示文摘TINTO A LLOYD D A KANG J Y 2002Aliment Pharmacol Ther2002,16,12:1
14Effective thermal conductivity of composites with interfacial thermal barrier resistance显示文摘HASSELMAN D P H LLOYD F J 1987Journal of Composites1987,21,6:1
15Studying grain fragmentation in ECAE by simulating simple shear显示文摘WU P D HUANG Y LLOYD D J 0,,:1
16Effect of commercial processing on antioxidants in rice bran显示文摘LLOYD B J SIEBENMORGEN T J BEERS K W 2000Cereal Chemistry2000,77,5:1
17Synchronized excitation of fluorescence emission spectra显示文摘LLOYD J B F 1971Nature Physical Science1971,231,:1
18Outcomes from mild and moder- ate traumatic brain injuries among children and adolescents:A system- atic review of studies from 2008-2013 显示文摘Lloyd J Wilson ML Tenovuo O 2015Brain Inj2015,29,5:1
19FGF21 reverses hepatic steatosis, increases energy expenditure and improves insulin sensitivity in diet-induced obese mice 显示文摘XU Jing LLOYD D J HALE C 2009Diabetes2009,58,1:1
20Takot subo cardiomyopathy (left ventricular ballooning syn drome) induced during dobutamine stress echocardio graphy显示文摘SILBERBAUER J HONG P LLOYD G W 2008Eur J Echocardiogr2008,9,:1
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