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| 1 | Plasma betatrophin levels in patients with liver cirrhosis显示文摘AIM: To investigate the plasma levels of betatrophin in patients with cirrhosis.METHODS: Forty patients diagnosed at the clinic with liver cirrhosis according to biological, ultrasonographic,or histological criteria were included.The severity of cirrhosis was classified according to Pugh's modification of Child's classification and MELD score. Insulin resistance(IR) was assessed by the Homeostasis Model Assessment. A total of 20 patients showed a MELD score higher than 14. The control group consisted in 15 sex-and aged-matched subjects.Fasting blood samples were obtained for subsequent analysis. Serum insulin was determined by Liaison automated immune chemiluminiscence assay(DiaSorin S.p.A.) using a sandwich assay. The sensitivity of the assay was 0.2 μU/mL. The intra and interassay variation coefficients were < 4% and < 10%,respectively. The normal values were between 2 and17 μU/mL. Human active betatrophin was analyzed by specific quantitative sandwich ELISA(Aviscera Bioscience). The sensitivity of the assay was 0.4 ng/mL, and the intra and interassay reproducibility were< 6% and < 10%, respectively.RESULTS: Plasma betatrophin levels were significantly increased in patients with cirrhosis compared with those in healthy subjects(P = 0.0001). Betatrophin levels were also associated with disease severity, being higher in Child-Pugh C patients compared to Child-Pugh B(P< 0.0005) and in patients who displayed a MELD score higher than 14 points compared to patients with lower punctuation(P = 0.01). In addition, we found a positive correlation between plasma betatrophin levels and the severity of cirrhosis according to Child-Pugh classification(r = 0.53; P < 0.01) or MELD score(r = 0.45; P <0.01). In the overall cohort, a moderate correlation between serum betatrophin and plasmatic bilirrubin(r= 0.39; P < 0.01) has been observed, as well as an inverse correlation between betatrophin and albumin(r =-0.41; P < 0.01) or prothrombin time(r =-0.44;P <0.01). Moreover, insulin resistance was observed in82.5% of the cirrhotic patients. In this group of patients,betatrophin levels were significantly higher than those in the group of patients without IR(P < 0.05).CONCLUSION: Plasma betatrophin is increased in patients with cirrhosis. This increase is related to the severity of cirrhosis, as well as with the emergence of insulin resistance. | Maria Teresa Arias-Loste Maria Teresa García-Unzueta Susana Llerena Paula Iruzubieta Angela Puente Joaquín Cabezas Carmen Alonso Antonio Cuadrado José Antonio Amado Javier Crespo Emilio Fábrega | 2015 | World Journal of Gastroenterology2015，21，37： | 9 |
| 2 | Impact of an acute hemodynamic response-guided protocol for primary prophylaxis of variceal bleeding显示文摘AIM To evaluate the long-term outcome of an acute hemodynamic response-guided protocol in which acute responders to intravenous propranolol received traditional nonselective beta-blockers(NSBBs) and acute nonresponders received carvedilol.METHODS Retrospective review of a protocol for primary prophylaxis of variceal bleeding guided by the acute hemodynamic response to intravenous propranolol. Fifty-two acute responders treated with traditional NSBB(i.e. propranolol or nadolol) were compared with 24 acute nonresponders receiving carvedilol. A second hemodynamic study was performed in 27 and 13 patients, respectively. The primary endpoint was development of first or further decompensation. Secondary endpoints included death from any cause, association between acute and chronic hemodynamic response, and baseline clinical and laboratory variables related to the acute hemodynamic response.RESULTS Acute responders and acute nonresponders presented similar 1, 2, and 3-year probabilities of first decompensation(NSBB: 0%, 13.7%, 26.1% vs carvedilol: 0%, 20%, 20%, P = 0.968) or further decompensation(21.2%, 26.1%, 40.9% vs 21.2%, 50.0%, 50.0%, P = 0.525). A previous episode of hepatic encephalopathy was the only independent predictor of decompensation [hazard ratio(95% confidence interval): 8.03(2.76-23.37)]. Mortality rates were similar in acute responders and acute nonresponders with compensated(P = 0.428) or decompensated cirrhosis(P = 0.429). No clinical, laboratory, endoscopic or hemodynamic parameter predicted the acute hemodynamic response. In patients receiving traditional NSBB, the acute and chronic changes of hepatic venous pressure gradient were correlated(r = 0.59, P = 0.001). Up to 69.2% of acute nonresponders gained chronic response with carvedilol.CONCLUSION Early identification and treatment with carvedilol of acute nonresponders to intravenous propranolol improves the clinical outcome of this high-risk group of patients, probably due to its greater effects for reducing portal pressure. | José Ignacio Fortea ángela Puente Patricia Ruiz Iranzu Ezcurra Javier Vaquero Antonio Cuadrado María Teresa Arias-Loste Joaquín Cabezas Susana Llerena Paula Iruzubieta Carlos Rodríguez-Lope Patricia Huelin Fernando Casafont Emilio Fábrega Javier Crespo | 2018 | World Journal of Clinical Cases2018，6，13： | 6 |
| 3 | The relationships be-tween science, technologies and their industrial exploita- tion: an illustration through the myths and realities of the so- called European paradox显示文摘 | Dosi G Llerena P Labini M S | 2006 | Research Policy2006，35，10： | 1 |
| 4 | The relationships between science, technologies and their industrial exploitation:an illustra- tion through the myths and realities of the so-called European paradox 显示文摘 | DOSI G LLERENA P LABINI M S | 2006 | Research Policy2006，35，10： | 1 |
| 5 | QTc in- terval lengthening is related to CYP2D6 hydroxyl-ation capacity and plasma concentration of thio- ridazine in patients显示文摘 | Llerena A Berecz R de la Rubia A | 2002 | J Psyehopharmacol2002，16，4： | 1 |
| 6 | Green consumer behaviour: an experimental analysis of willingness to pay for remanufactured products显示文摘 | Michaud C Llerena D | 2011 | Business Strategy and the Environment2011，20，6： | 1 |
| 7 | QTc inter- val, CYP2D6 and CYP2C9 genotypes and risperi- done plasma concentrations 显示文摘 | Llerena A Berecz R Dorado P | 2004 | J Psychopharma- col2004，18，2： | 1 |
| 8 | Early ICU energy deficit is a risk factor for Staphylococcus aureus ventilator-associat- ed pneumonia显示文摘 | Faisy C Candela Llerena M Savalle M | 2011 | Chest2011，140，5： | 1 |
| 9 | Green consumer behavior:an experimental analysis of willihgness to pay for remanufactured products显示文摘 | Celine Michaud Daniel Llerena | | 0，，06： | 1 |
| 10 | Epidermoid cyst ( Mono-dermal teratoma ) of the testis 显示文摘 | Reinberg Y Manivel JC Llerena J | 1990 | Br J Urol1990，66，4： | 1 |
| 11 | Effect of thioridazine dosage on the debrisoquine hydroxyl- ation phenotype in psychiatric patients with differ- ent CYP2D6 genotypes 显示文摘 | Llerena A Berecz R de la Rubia A | 2001 | Ther Drug Monit2001，23，6： | 1 |
| 12 | Eco - Innovation Through Integration, Regulation and Cooperation: Comparative Insights from Case Studies in Three Manufacturing Sectors 显示文摘 | WAGNER M LLERENA P | 2011 | Industry and Innovation2011，18，8： | 1 |
| 13 | Epidermoid cyst (monodermal teratoma) of the testis显示文摘 | Reinberg Y Manivel JC Llerena J | 1990 | Br J Urol1990，66，6： | 1 |
| 14 | CYP2D6 polymorphism: implications for antipsychotie drug response, schizophrenia and personality traits显示文摘 | Dorado P Penas-Lledo EM Llerena A | 2007 | Pharmacogenomics2007，8，11： | 1 |
| 15 | Sonographic findings in a case of tetrasomy 9p associated with increased nuchal translucency and Dandy-Walker malformation显示文摘 | Nakamura-Pereira M Cima LC Llerena JC Jr | 2009 | J Clin Ultrasound2009，37，8： | 1 |
| 16 | Convex decomposition of games and axiomatizations of the core and the D-core显示文摘 | Llerena F Rafel C | 2007 | Intemational Journal of Game Theory2007，，35： | 1 |
| 17 | Early ICU energy deficit is a riskfactor for Staphylococcus anreus ventilator-associate pneumonia 显示文摘 | Faisy C Candela Llerena M Savalle M | 2011 | Chest2011，140，5： | 1 |
| 18 | Synthesis of variously substituted allenediynes and their cobalt (I)-mediated [2+2+2] cycloaddition reactions显示文摘 | Dominique Llerena Olivier Buisine Corinne Aubert Max Malacria | 1998 | Tetrahedron1998，，32： | 1 |
| 19 | Enantiomeric determination,validation and robustness studies of racemic citalopram in pharmaceutical formulations by capillary electrophoresis显示文摘 | BERZAS NEVADO JJ GUIBERTEAU CABANILLAS C VILLASEOR LLERENA MJ | 2005 | J Chromatogr A2005，1072，2： | 1 |
| 20 | Organisational rules, codification and knowledge creation in inter -organisation cooperative agreements 显示文摘 | AVADIKYAN A LLERENA P MIREILLE ROZAN ANNE | 2001 | Research Policy2001，30，： | 1 |
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