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| 1 | Th1 cytokines promote T-cell binding to antigen-presenting cells via enhanced hyaluronan production and accumulation at the immune synapse显示文摘Hyaluronan(HA)production by dendritic cells(DCs)is known to promote antigen presentation and to augment T-cell activation and proliferation.We hypothesized that pericellular HA can function as intercellular‘glue’directly mediating T cell–DC binding.Using primary human cells,we observed HA-dependent binding between T cells and DCs,which was abrogated upon pre-treatment of the DCs with 4-methylumbelliferone(4-MU),an agent which blocks HA synthesis.Furthermore,T cells regulate HA production by DCs via T cell-derived cytokines in a T helper(Th)subset-specific manner,as demonstrated by the observation that cell-culture supernatants from Th1 but not Th2 clones promote HA production.Similar effects were seen upon the addition of exogenous Th1 cytokines,IL-2,interferon c(IFN-c)and tumor necrosis factor a(TNF-a).The critical factors which determined the extent of DC–T cell binding in this system were the nature of the pre-treatment the DCs received and their capacity to synthesize HA,as T-cell clones which were pre-treated with monensin,added to block cytokine secretion,bound equivalently irrespective of their Th subset.These data support the existence of a feedforward loop wherein T-cell cytokines influence DC production of HA,which in turn affects the extent of DC–T cell binding.We also document the presence of focal deposits of HA at the immune synapse between T-cells and APC and on dendritic processes thought to be important in antigen presentation.These data point to a pivotal role for HA in DC–T cell interactions at the IS. | Paul L Bollyky Stephen P Evanko Rebecca P Wu Susan Potter-Perigo S Alice Long Brian Kinsella Helena Reijonen Kelly Guebtner Brandon Teng Christina K Chan Kathy R Braun John A Gebe Gerald T Nepom Thomas N Wight | 2010 | Cellular & Molecular Immunology2010，7，3： | 3 |
| 2 | 饲料中添加蛋白酶对肉鸡性能、养分利用率、肠道形态和胴体品质的影响显示文摘试验在饲喂玉米、高粱为主的肉鸡日粮中补充大豆,并添加蛋白酶,研究蛋白酶对肉鸡性能、养分消化率、肠道形态和胴体品质的影响。试验选取1日龄AA肉仔鸡(43.8±1.31 g)256只,均为公鸡,随机分配到2×2试验设计方阵中,方阵包括正常组(玉米组和高粱组)和蛋白酶组(空白组和添加蛋白酶150 mg·kg^(-1)的试验组)。试验1~21 d为第一阶段,22~42 d为第二阶段。试验结果表明,第二阶段中,日粮中添加蛋白酶极显著提高肉鸡的平均日增重(ADG,P<0.01),在整个试验过程中显著提高(P<0.05)。在各个时期,正常组对肉鸡生产性能均无显著影响(P>0.05)。19~21 d时,添加蛋白酶可显著提高肉鸡的表观代谢能(AME),干物质(DM)、总能量(GE)和养分消化率(P<0.05)。此外,日粮以高粱为主时,AME、GE消化率有降低趋势(P=0.05),氮沉积率也有降低趋势(P=0.08)。40~42 d时,日粮中添加蛋白酶可显著提高AME,DM、GE和氮沉积率(P<0.05)。21 d时,日粮中添加蛋白酶极显著增加肠绒毛高度、肠绒毛与隐窝深度比值,极显著降低十二指肠、空肠、回肠的隐窝深度(P<0.01)。42 d时,日粮中添加蛋白酶显著增加空肠肠绒毛高度、绒毛高度与隐窝深度比值,显著降低隐窝深度(P<0.05)。日粮中添加蛋白酶显著增加胸肌重、24 h p H,显著降低胸肌的滴水损失(P<0.05)。试验结果表明,饲养阶段日粮中添加复合蛋白酶可提高肉鸡ADG;在第一阶段可改善AME、DM、GE和氮沉积率和肠道形态。补充蛋白酶可提高出栏重、胸肌重和24 h pH,降低胸肌的滴水损失。低单宁高粱日粮与玉米日粮相比,对肉鸡性能的影响相近。 | Xu X Wang H L Pan L Ma X K Tian Q Y Xu Y T Long S F Zhang Z H Piao X S | 2017 | 饲料博览2017，0，1： | 2 |
| 3 | Measurement of leaf and canopy photosynthetic C02 exchange in the field显示文摘 | Farageand P K Garcia R L | 1996 | Journal of Experimental Botany1996，47，304： | 1 |
| 4 | A Confidence Limit for the Empirical Mode Decomposition and Hilbert Spectral Analysis显示文摘 | Huang N E Wu M L Long S R | 2003 | Proceedings of the Royal Society of London2003，459，： | 1 |
| 5 | Stable chlorine isotopes in halite and brine from the Gulf Coest Basin: brine genesis and evolution显示文摘 | Eastoe C J Long A Land L S | 2001 | Chemical Geology2001，176，14： | 1 |
| 6 | Can improved photosynthesis increase crop yields? 显示文摘 | Long S P Zhu X G Naidu S L | 2006 | Plant Cell Environ2006，29，： | 1 |
| 7 | A confidence limit for the empirical mode decomposition and Hilbert spectral analysis 显示文摘 | Huang N E Wu M L C Long S R | 2003 | Proceedings Royal of Society A2003，459，： | 1 |
| 8 | Properties ofwool fibers treated under high - temperature water and steam显示文摘 | Long L Lei S Guiqin J | 2008 | J Appl Polym Sci2008，，109： | 1 |
| 9 | CH4-CO2 reforming by plasma-challenges and opportunities显示文摘 | TAO X M BAI M G LI X LONG H L SHANG S Y YIN Y X DAI X Y | | 0，，02： | 1 |
| 10 | Incidence of adverse biological effects within ranges of chemical concentrations in marine and estuarine sediments 显示文摘 | Long E R MacDonald D D Smith S L | 1996 | Environmental Management1996，19，1： | 1 |
| 11 | General scheme for super dense coding between multi-parties 显示文摘 | LIU X S LONG G L TONG D M | 2002 | Phys Rev2002，，02： | 1 |
| 12 | Incidence of adverse biological effects with ranges v of chemical concentrations in marine and estuarine sediments显示文摘 | LONG E R MACDONALD D D SMITH S L | 1995 | Environmental Management1995，19，1： | 1 |
| 13 | A confidence limit for the empirical mode decomposition and Hilbert spectral analysis显示文摘 | Huang N E Wu M L long S R | 2003 | Proc Royal Society of London Series2003，459，： | 1 |
| 14 | Incidence of adverse biological effects with ranges of chemical concentrations in marine and estuarine sediments显示文摘 | Long E R Macdonald D D Smith S L | | 0，，1： | 1 |
| 15 | Effect of annealing on mechanical properties of copper alloys deformed at cryogenic temperature 显示文摘 | WU X GONG Y REN S TAO J LONG Y CHENG L ZHU X | 2013 | Materials Science Forum2013，，： | 1 |
| 16 | Implications of Land-use Change in Rural China:A Case Study of Yucheng, Shan- dong Province显示文摘 | Liu Y S Yang R Long H L | 2014 | Land Use Policy2014，40，： | 1 |
| 17 | Can improvement in photosynthesis increase crop y eldsV显示文摘 | Long S P Zhu X G Naidu S L Ort D R | 2006 | Plant Cell Environment2006，29，3： | 1 |
| 18 | Incidence of adverse biological effects with ranges of chemical concentrations in marine and estuarine sediments 显示文摘 | Long E R Macdonald D D Smith S L | 1995 | Environmental Management1995，19，1： | 1 |
| 19 | Studies on comparison of esterase isozyme of different species of Trichogramma显示文摘 | CAO G L LU W Q LONG S | 1988 | Colloques de 1'' INRA1988，43，： | 1 |
| 20 | Impact of TCSC control methodologies on subsynchronous oscillations显示文摘 | Pilotto L A S Bianco A Long W F | 2003 | IEEE Trans on Power Delivery2003，18，1： | 1 |
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