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| 1 | Chronic antiepileptic drug use and functional network efficiency: A functional magnetic resonance imaging study显示文摘AIM To increase our insight in the neuronal mechanisms underlying cognitive side-effects of antiepileptic drug(AED) treatment.METHODS The relation between functional magnetic resonance-acquired brain network measures, AED use, and cognitive function was investigated. Three groups of patients with epilepsy with a different risk profile for developing cognitive side effects were included: A 'low risk' category(lamotrigine or levetiracetam, n=16), an 'intermediate risk' category(carbamazepine, oxcarbazepine, phenytoin, or valproate, n=34) and a 'high risk' category(topiramate, n=5). Brain connectivity was assessed using resting state functional magnetic resonance imaging and graph theoretical network analysis. The Computerized Visual Searching Task was used to measure central information processing speed, a common cognitive side effect of AED treatment. RESULTS Central information processing speed was lower in patients taking AEDs from the intermediate and high risk categories, compared with patients from the low risk category. The effect of risk category on global efficiency was significant(P < 0.05, ANCOVA), with a significantly higher global efficiency for patient from the low category compared with the high risk category(P < 0.05, post-hoc test). Risk category had no significant effect on the clustering coefficient(ANCOVA, P > 0.2). Also no significant associations between information processing speed and global efficiency or the clustering coefficient(linear regression analysis, P > 0.15) were observed. CONCLUSION Only the four patients taking topiramate show aberrant network measures, suggesting that alterations in functional brain network organization may be only subtle and measureable in patients with more severe cognitive side effects. | Tamar M van Veenendaal Dominique M IJff Albert P Aldenkamp Richard H C Lazeron Paul A M Hofman Anton J A de Louw Walter H Backes Jacobus F A Jansen | 2017 | World Journal of Radiology2017，9，6： | 2 |
| 2 | The predictive validity of general movements--a systematic revicw显示文摘 | Burger M Louw QA | 2009 | Eur J Paediatr Neurol2009，13，5： | 1 |
| 3 | A study of soil bacteria dissolving certain mineral phospnate fertilizers and related compounds显示文摘 | Louw H A Webley D M | 1959 | Applied Bacteriology1959，22，3： | 1 |
| 4 | Cu-curbitacin B inhibits growth,arrests the cell cycle,and potentiatesantiproliferative efficacy of cisplatin in cutaneous squamous cell car-cinoma cell lines显示文摘 | Chen W Leiter A Yin D Meiring M Louw VJ Koeffler HP | 2010 | Int J Oncol2010，37，3： | 1 |
| 5 | Rep-PCR-mediated genomic fingerprinting:a rapid and effective method to identify Clavibacter michiganensis显示文摘 | Louws F J Bell J Medina-Mora C M | 1998 | Phytopathology1998，88，： | 1 |
| 6 | Spinal stenosis following anterior spinal fusion显示文摘 | LOUW J A DOMMISSEE G F ROOS M F | 1988 | Spine1988，13，8： | 1 |
| 7 | Ceneral movements as a predictive 1001 of the neurological outcome in very low and extremely low birth weight infants-a South African perspr-ctive显示文摘 | Burger M Frieg A Louw QA | 2011 | Early Hum Dev2011，87，4： | 1 |
| 8 | Species composition of endophytic fungi in Amaranthus hybridus leaves, petioles, stems, and roots 显示文摘 | Blodgett J T Swart W J Louw S M | 2000 | Mycologia2000，92，5： | 1 |
| 9 | Ultrasonography-guided fine needle aspiration for the assessment of cervical metastases显示文摘 | Knappe M Louw M Cregor RT | 2000 | Arch Otolaryngol Head Neck Surg2000，126，9： | 1 |
| 10 | The predictive validity of generalmovements-a systematic review 显示文摘 | Burger M Louw QA | 2009 | Eur J Paediatr Neu-rol2009，13，5： | 1 |
| 11 | A comparative study on plant growth and root plasticity responses of two Brachiaria forage grasses grown in nutrient solution at low and high phosphorus supply 显示文摘 | LOUWGAUME A E RAO I M GAUME A J | 2010 | Plant and Soil2010，328，： | 1 |
| 12 | Methyl bromide alternatives for control of black root rot of straw- berry in Georgia 显示文摘 | BRANNEN P M FERGUSON L M LOUWS F J | 2004 | Phytopathology2004，94，6： | 1 |
| 13 | A study of soil bacteria dissolving certain mineral phosphate fertilizers and related compounds显示文摘 | Louw H A Webley D M | 1959 | Appl Bacteriol1959，，22： | 1 |
| 14 | Positive end-expiratory pressure may alter breathing cardiovascular vari-ability and baroreflex gain in mechanically ventilated pa-tients显示文摘 | Van de Louw A Médigue C Papelier Y | | 0，，： | 1 |
| 15 | Emotional Confidence Levels and Success of Tourism Development for Poverty Reduction: The South African Kwame Makana Home-stay Project显示文摘 | Kwaramba H M Lovett J C Louw L | 2012 | Tourism Management2012，33，4： | 1 |
| 16 | The predictive validity of general movements-a systematic review显示文摘 | Burger M Louw QA | 2009 | Eur J Paediatr Neurol2009，13，5： | 1 |
| 17 | Chlorine input and chlorophenol emission in the lab-scale combustion of municipal solid waste显示文摘 | Kanters M J Vannispen R Louw R | 1996 | Environmental Science&Technology1996，30，7： | 1 |
| 18 | Nocardial infection as a complication of HIV in South Africa显示文摘 | Jones N Khoosal M Louw M | | 0，，03： | 1 |
| 19 | Incidence and clinicopathogical features of meningioma显示文摘 | Sutherland GR Louw DF | 1989 | J Neurosurg1989，71，51： | 1 |
| 20 | A compre hensive species to strain taxonomic framework for Xan thomonas显示文摘 | Rademaker J L W Louws F J Schultz M H | 2005 | Phytopathology2005，95，： | 1 |
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