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| 1 | 胚胎巨噬细胞和小胶质细胞消融调控小鼠胚胎背根神经节感觉神经元的发育显示文摘众所周知,小胶质细胞可以调节中枢神经系统发育的一些方面。在第11.5天的小鼠胚胎中的小胶质细胞定殖脊髓时,它们与背根神经节感觉神经元(SN)的生长中心轴突相互作用,这表明它们可能在SN发育中发挥一定功能。为了解决这个问题,我们使用缺乏胚胎巨噬细胞(PU.1敲除小鼠)和免疫细胞消融的小鼠胚胎分析胚胎巨噬细胞消融对SNs早期发育的影响。我们发现,除小胶质细胞外,胚胎巨噬细胞还与来自第11.5天的小鼠胚胎的原肌球蛋白受体激酶(Trk)C+感觉神经元,TrkB+感觉神经元和TrkA+感觉神经元外周神经突产生交联。免疫细胞剥夺会导致第11.5天的小鼠胚胎的TrkC+感觉神经元和TrkB+感觉神经元初始数量的减少,这与其发育细胞死亡(DCD)的改变有关联的可能性较小,因为其后在第12.5天的胚胎中的数量有短暂增加。在分析的发育期(第11.5~15.5天),它也导致TrkA+感觉神经元数量减少,尽管我们没有观察到他们的DCD有任何变化。与神经元祖细胞可能存在一致性的脑脂肪酸结合蛋白(BFABP-)阴性细胞的增殖在第11.5天的胚胎中增加,而它们的增殖在第12.5天的胚胎减少,这可部分解释从11.5 d观察到的SN亚型产生的改变。此外,我们观察到在缺乏胚胎巨噬细胞的情况下神经胶质细胞祖细胞(BFABP+细胞)增殖的改变。我们的数据表明,胚胎巨噬细胞和小胶质细胞消融调控SN的发育。 | Angelim MKSC Maia LMSS Mouffle C Ginhoux F Low D Amancio-Dos-Santos A Makhoul J Le Corronc H Mangin JM Legendre P 聂昊(编译) | 2018 | 神经损伤与功能重建2018，13，9： | 2 |
| 2 | A qualitative exploration of a respiratory distress symptom cluster in lung cancer: Cough, breathlessness and fatigue显示文摘 | Molassiotis A Lowe M Blackball F | 2011 | Lung Cancer2011，71，1： | 1 |
| 3 | Acute upper gastrointestinal bleeding in the UK:patient characteristics,diagnoses and outcomes in the 2007 UK audit显示文摘 | Hearnshaw S A Logan R F Lowe D | 2011 | Gut2011，60，10： | 1 |
| 4 | Quantitation of gene expression in neural precursors by reverse-transcription polymerase chain reaction using self-quenched, fluorogenic primers显示文摘 | Lowe B Avila H A Bloom F R | 2003 | Anal Biochem2003，315，： | 1 |
| 5 | Rapid stimulation of an oxidative burst during elicitation of cultured plant cells显示文摘 | APROSTOLL A HEINSTEIN P F LOW P S | 1989 | Plant Physiol1989，90，： | 1 |
| 6 | Transferability and genome specificity of a new set of microsatellite primers among Brassica species of the U triangle显示文摘 | Lowe A J Jones A E Raybould A F | 2002 | Molecular Ecology Notes2002，2，： | 1 |
| 7 | In-situ determination of thermal coefficients for electrical machines显示文摘 | Bousbaine A McCormick M Low W F | 1995 | IEEE Transactions of Energy Conversion1995，10，3： | 1 |
| 8 | Discordant atrial natriuretic peptide and brain natriuretic peptide levels in lone atrial fibrillation 显示文摘 | Ellinor P T Low A F Patton K K | 2005 | J Am Coll Cardiol2005，45，1： | 1 |
| 9 | Surface area development of sewage sludge during pyrolysis显示文摘 | Gao Qinglu Low J C F Lua A C | 1995 | Fuel1995，74，： | 1 |
| 10 | Document identification for copyright protection using centroid detection 显示文摘 | LOW S H MAXEMCHUK N F LAPONE A M | 1998 | IEEE Trans on Communications1998，46，3： | 1 |
| 11 | Electrodeposition of composite coatings containing nanoparticles in a metal deposit显示文摘 | LOW C T J WILLS R G A WALSH F C | 2006 | Surface & Coatings Technology2006，201，： | 1 |
| 12 | Interleukin-6 -174G>C polymorphism and risk of coronary heart disease in West of Scotland coronary prevention study (WOSCOPS)显示文摘 | BASSO F LOWE G D RUMLEY A | 2002 | Arterioscler Thromb Vasc Biol2002，22，： | 1 |
| 13 | Production of soluble triggering receptor expressed on myeloid cells by lipopolysaccharide-stimulated human neutrophils involves de novo protein synthesis显示文摘 | MAHDY A M LOWES D A GALLEY H F | 2006 | Clin Vaccine Immunol2006，13，4： | 1 |
| 14 | Genetic effects of chronic habitat fragmentation on tree species:the case of Sorbus aucuparia in a deforested Scottish landscape显示文摘 | BACLES C F E LOWE A J ENNOSI R A | 2004 | Molecular Ecology2004，13，： | 1 |
| 15 | Document Identification for Copyright Protection Using Centroid Detection显示文摘 | Low S H Maxemchuk N F Lapone A M | 1998 | IEEE Transactions on Communications1998，46，3： | 1 |
| 16 | Osmosis in argillaceous rocks显示文摘 | Young A Low P F | 1965 | AAPG Bulletin1965，49，7： | 1 |
| 17 | Electrodeposition of composite coatings containing nanoparticles in a metal deposit显示文摘 | LOW C T J WILLS R G A WALSH F C | 2006 | Surface & Coating Technology2006，201，： | 1 |
| 18 | Properties oflncone1625 mesh structures grown by electron beam additive manufacturing 显示文摘 | List F A DehoffR R Lowe L E | 2014 | MaterialsScienceandEngineeringA2014，615，： | 1 |
| 19 | The high reactivity of peroxiredoxin 2 with H(2)O(2)is not reflected in its reaction with other oxidants and thiol reagents显示文摘 | Peskin A V Low F M Paton L N | 2007 | Biol Chem2007，282，11： | 1 |
| 20 | Effects of a mandibular reposition-ing appliance used in the treatment of obstructive sleep apnea ontongue muscle activity 显示文摘 | Lowe A Fleetham J R yan F | 1990 | Prog Clin Biol Res1990，，345： | 1 |
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