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| 1 | Curculigoside isolated from Curculigo orchioides prevents hydrogen peroxide-induced dysfunction and oxidative damage in calvarial osteoblasts显示文摘反应的氧种类(ROS ) 包括 H2O2,在骨质疏松症的 pathophysiology 起一个关键作用。因此,能禁止 ROS 生产的代理人或抗氧化剂在骨质疏松症的治疗有高临床的价值。Curculigoside (杂种狗) ,酉分的混合物从 Curculigo orchioides Gaertn 的根茎孤立的主要 bioactive 之一,被报导有有势力抗氧化剂和 anti-osteoporotic 性质。然而,没有直接证据与观察 anti-osteoporotic 效果连接杂种狗的抗氧化剂能力,并且相关分子的机制仍然保持不清楚。因此,我们在 calvarial 造骨细胞对氧化应力调查了杂种狗的保护的效果并且讨论了相关机制。造骨细胞生存能力在 48-h 暴露以后显著地减少了到 H2O2 的 400 M,这被发现,与对待车辆的房间相比,并且 H2O2 的细胞毒素的效果显著地被颠倒什么时候有杂种狗的 0.110 M 的 pretreated (P < 0.05 ) 。有杂种狗的 0.110 M 的预告的处理减少了 ROS 生产和类脂化合物 peroxidation,并且增加了抗氧化剂酶的活动,例如 superoxide,在造骨细胞的 dismutase 和谷胱甘肽 peroxidase 由 H2O2 导致了。另外,象碱的磷酸酶,钙免职,和 Runx2 水平那样的区别标记的导致 H2O2 的减小显著地面对杂种狗被恢复。杂种狗也颠倒了细胞外的调整信号的 kinase 1/2,并且原子 factor-B 发信号和 p38 的抑制的导致 H2O2 的刺激激活 mitogen 的蛋白质 kinase 激活。这些结果通过减少 ROS 的生产提供新卓见进杂种狗的造骨细胞保护的机制,建议那条杂种狗可以作为为骨质疏松症和另外的骨头相关的人的疾病的预防和处理的一个对简历安全的代理人被开发。 | Ying Wang Lu Zhao Yin Wang Jinlong Xu Yah Nie Yuanhui Guo Yongtao Tong Luping Qin Qiaoyan Zhang | 2012 | Acta Biochimica et Biophysica Sinica2012，44，5： | 15 |
| 2 | Chang'E-1 Lunar Mission:An Overview and Primary Science Results显示文摘Chang'E-1 is the first lunar mission in China,which was successfully launched on Oct.24th,2007.It was guided to crash on the Moon on March 1,2009,at 52.36°E,1.50°S,in the north of Mare Fecunditatis.The total mission lasted 495 days,exceeding the designed life-span about four months.1.37Terabytes raw data was received from Chang'E-1.It was then processed into 4Terabytes science data at different levels.A series of science results have been achieved by analyzing and applicating these data,especially 'global image of the Moon of China's first lunar exploration mission'.Four scientific goals of Chang'E-1 have been achieved.It provides abundant materials for the research of lunar sciences and cosmochemistry.Meanwhile these results will serve for China's future lunar missions. | Ouyang Ziyuan Li Chunlai Lu Chang Liu Jianzhong Zou Yongliao Zhang Hongbo Jianjun Zuo Wei Su Yah Wen Weibin Bian Wei Zhao Baochang Wang Jianyu Yang Jianfeng Chang Jin Wang Huanyu Zhang Xiaohui Wang Shijin Wang Min Ren Xin Mu Lingli Kong Deqing Wang Xiaoqian Wang Fang Geng Liang Zhang Zhoubin Zheng Lei Zhu Xinying Zheng Yongchun Li Junduo Zou Xiaoduan Xu Chun Shi Shuobiao Gao Yifei Gao Guannan | 2010 | 空间科学学报2010，30，5： | 11 |
| 3 | Female Fertility: Is it Safe to Freeze.显示文摘 | Lu Zhang Li-Ying Yan Xu Zhi Jie Yah Jie Qiao | 2015 | Chinese Medical Journal2015，，3： | 11 |
| 4 | Expert Consensus on Clinical Diagnostic Criteria for Fatal Familial Insomnia显示文摘 | Li-Yong Wu Shu-Qin Zhan Zhao-Yang Huang Bin Zhang Tao Wang Chun-Feng Liu Hui Lu Xiao-Ping Dong Zhi-Ying Wu Jie-Wen Zhang Ji-Hui Zhang Zhong-Xin Zhao Fang Han Yah Huang Jun Lu Serge Gauthier Jian-Ping Jia Yu-Ping Wang | 2018 | Chinese Medical Journal2018，，13： | 10 |
| 5 | Genome evolution trend of common carp (Cyprinus carpio L.) as revealed by the analysis of microsatellite loci in a gynogentic family显示文摘Genome evolution arises from two main ways of duplication and reduction. Fish specific genome duplication (FSGD) may have occurred before the radiation of the teleosts. Common carp (Cyprinus carpio L.) has been considered to be a tetraploid species, because of its chromosome numbers (2n=100) and its high DNA content. Using 69 microsatellite primer pairs, the variations were studied to better understand the genome evolution (genome duplication and diploidization) of common carp from a gynogenetic family. About 48% of primer pairs were estimated to amplify duplicates based on the number of PCR amplification per individual. Segregation patterns in the family suggested a partially duplicated genome structure and disomic inheritance. This indicates that the common carp is tetraploid and polyploidy occurred by allotetraploidy. Two primer pairs (HLJ021 and HLJ332) were estimated to amplify reduction based on the number of PCR amplification per individual. One allele in HLJ002 locus and HLJ332 locus was clearly lost in the gynogenetic family and the same as in six wild populations. Segregation patterns in the family suggested a partially diplodization genome structure. A hypothesis transition (dynamic) and equilibrium (static) were proposed to explain the common carp genome evolution between genome duplication and diploidization. | Yah Zhang Liqun Liang Peng Jiang Dayu Li Cuiyun Lu Xiaowen Sun | 2008 | Journal of Genetics and Genomics2008，35，2： | 7 |
| 6 | Late Neolithic expansion of ancient Chinese revealed by Y chromosome haplogroup O3alc-002611显示文摘 | Chuan-Chao WANG Shi YAN Zhen-Dong QIN Yah LU Qi-Liang DING Lan-Hai WEI Shi-Lin LI Ya-Jun YANG Li JIN Hui LI Genographic Consortium | 2013 | Journal of Systematics and Evolution2013，51，3： | 6 |
| 7 | A mechanical model of borehole stability for weak plane formation under porous flow 显示文摘 | Lu Yunhu Chen Mian Jin Yah | 2012 | Petroleum Science & Technology2012，30，15： | 1 |
| 8 | Rapid analysis of the in-process extract solutions of compound E Jiao oral liquid using near infrared spectroscopy and partial least-squares regression 显示文摘 | Han Hal Fan Zhang Lu Zhang Yah | 2013 | Anal Method2013，5，： | 1 |
| 9 | Dis- section of a flexible wing's performance for insect-in- spired flapping-wing micro air vehicles 显示文摘 | Lu Guang Yah Jingping Zhang Zhisheng | 2012 | Advanced Robotics2012，26，56： | 1 |
| 10 | Cr(VI) reduction at rutile-catalyzed cathode in microbial fuel cells 显示文摘 | Li Y Lu AH Ding HR Jin S Yah YH Wang CQ Zen CP Wang H | 2009 | Electrochem Commun2009，11，7： | 1 |
| 11 | Frontal polymerization synthesis of monolithic macroporous polymers显示文摘 | Yah Q Z Lu G D Zhang W F | 2007 | Advanced Functional Materials2007，17，16： | 1 |
| 12 | Microscopic phase-field study on aging behavior of NiTsAllTZns 显示文摘 | ZHAO Yah CHEN Zheng LU Yan-li ZHANG Li-peng | 2010 | Transactions of Nonferrous Metals Society of China2010，20，4： | 1 |
| 13 | Monitoring and characterisation of pulverised coal flames using digital imaging techniques显示文摘 | Yah Y Lu G Colechin M | | 0，，05： | 1 |
| 14 | Regulation of OsSPL14 by OsmiR156 defines ideal plant architecture in rice 显示文摘 | Jiao Y Wang Y Xue D Wang J Yah M Liu G Dong G Zeng D Lu Z Zhu X Qian Q Li J | 2010 | Nature Genetics2010，42，6： | 1 |
| 15 | Biochar supported nanoscale zerovalent iron composite used as persulfate activator for removing trichloroethylene 显示文摘 | Yah Jingchun Han Lu Gao Weiguo | 2015 | BioresourTechnol2015，175，： | 1 |
| 16 | Miscible crystalline/crystalline polymer blends of poly (vinylidene fluoride ) and poly (butylene succinate-co-butylene adipate ) : spherulitic morphologies and crystallization kinetics 显示文摘 | Qiu Z B Yah C Z Lu J M | 2007 | Macromolecules2007，40，14： | 1 |
| 17 | Egr - 1 a master switch coordinating up regulation of divergent gene families underlying is chemic stress 显示文摘 | Yah SF Fujita T Lu J | 2000 | Nat Med2000，6，12： | 1 |
| 18 | Improvement of the crystalline quality of the ZnO Epitaxial layer on a low-temperature grown ZnO buffer layer显示文摘 | Yah J F Lu Y M Liu Y C | 2004 | Journal of Crystal Growth2004，266，4： | 1 |
| 19 | image registration based on criteria of feature point pair mutual information 显示文摘 | Lu G Yah J | 2011 | lET Image Process2011，6，5： | 1 |
| 20 | Egr - 1, a master switch coordinating up regulationof divergent gene families underlying ischemic stress显示文摘 | Yah SF Fujita T Lu J | 2000 | Nat Med2000，6，12： | 1 |
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