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| 1 | Concordance of non-invasive mechanical and serum tests for liver fibrosis evaluation in chronic hepatitis C显示文摘AIM To determine the sensitivity and specificity of liver stiffness measurement(LSM) and serum markers(SM) for liver fibrosis evaluation in chronic hepatitis C.METHODS Between 2012 and 2014,81 consecutive hepatitis C virus(HCV) patients had METAVIR score from liver biopsy compared with concurrent results from LSM [transient elastography(TE) [FibroS can~/ARFI technology(Virtual Touch~)] and SM [FIB-4/aspartate aminotransferase-toplatelet ratio index(APRI)].The diagnostic performance of these tests was assessed using receiver operating characteristic curves.The optimal cut-off levels of each test were chosen to define fibrosis stages F ≥ 2,F ≥ 3 and F = 4.The Kappa index set the concordance analysis.RESULTS Fifty point six percent were female and the median age was 51 years(30-78).Fifty-six patients(70%) weretreatment-na?ve.The optimal cut-off values for predicting F ≥ 2 stage fibrosis assessed by TE were 6.6 kP a,for acoustic radiation force impulse(ARFI) 1.22 m/s,for APRI 0.75 and for FIB-4 1.47.For F ≥ 3 TE was 8.9 kP a,ARFI was 1.48 m/s,APRI was 0.75,and FIB-4 was 2.For F = 4,TE was 12.2 kP a,ARFI was 1.77 m/s,APRI was 1.46,and FIB-4 was 3.91.The APRI could not distinguish between F2 and F3,P = 0.92.The negative predictive value for F = 4 for TE and ARFI was 100%.Kappa index values for F ≥ 3 METAVIR score for TE,ARFI and FIB-4 were 0.687,0.606 and 0.654,respectively.This demonstrates strong concordance between all three screening methods,and moderate to strong concordance between them and APRI(Kappa index = 0.507).CONCLUSION Given the costs and accessibility of LSM methods,and the similarity with the outcomes of SM,we suggest that FIB-4 as well as TE and ARFI may be useful indicators of the degree of liver fibrosis.This is of particular importance to developing countries. | Denise C Paranaguá-Vezozzo Adriana Andrade Daniel F C Mazo Vinicius Nunes Ana L Guedes Taisa G Ragazzo Renata Moutinho Lucas S Nacif Suzane K Ono Venancio A F Alves Flair J Carrilho | 2017 | World Journal of Hepatology2017，9，8： | 7 |
| 2 | Tissue-specific transcriptional imprinting and heterogeneity in human innate lymphoid cells revealed by full-length single-cell RNA-sequencing显示文摘The impact of the microenvironment on innate lymphoid cell(ILC)-mediated immunity in humans remains largely unknown.Here we used full-length Smart-seq2 single-cell RNA-sequencing to unravel tissue-specific transcriptional profiles and heterogeneity of CD127+ILCs across four human tissues.Correlation analysis identified gene modules characterizing the migratory properties of tonsil and blood ILCs,and signatures of tissue-residency,activation and modified metabolism in colon and lung ILCs.Trajectory analysis revealed potential differentiation pathways from circulating and tissue-resident naïve ILCs to a spectrum of mature ILC subsets.In the lung we identified both CRTH2+and CRTH2−ILC2 with lung-specific signatures,which could be recapitulated by alarmin-exposure of circulating ILC2.Finally,we describe unique TCR-V(D)J-rearrangement patterns of blood ILC1-like cells,revealing a subset of potentially immature ILCs with TCR-δ rearrangement.Our study provides a useful resource for in-depth understanding of ILC-mediated immunity in humans,with implications for disease. | Luca Mazzurana Paulo Czarnewski Viktor Jonsson Leif Wigge Markus Ringnér Teresa CWilliams Avinash Ravindran Åsa KBjörklund Jesper Säfholm Gunnar Nilsson Sven-Erik Dahlén Ann-Charlotte Orre Mamdoh Al-Ameri Charlotte Höög Charlotte Hedin Sylwester Szczegielniak Sven Almer Jenny Mjösberg | 2021 | Cell Research2021，31，5： | 2 |
| 3 | Evaluation of the inhibitory effects of human serum components on bactericidal activity of human beta-defensin-3 显示文摘 | Maisetta G Di Luca M Esin S | 2008 | Peptides2008，29，1： | 1 |
| 4 | Phenolic ripeness assessment of grape skin by texture analysis 显示文摘 | Susana R S Luca R Vincenzo G | 2008 | Journal of Food Composition and Analysis2008，21，8： | 1 |
| 5 | Screening of virulence- associated genes as a molecular typing method for characteriza- tion of Streptococcus suis isolates recovered from wild boars and pigs显示文摘 | Veronica S R Jose F G Lucas D | 2016 | Vet J2016，209，： | 1 |
| 6 | 显示文摘 | Nagorka M S Levi C G Lucas G E | 1991 | Materials Science Engineering A1991，142，2： | 1 |
| 7 | Dinosaur skin impressions from the Upper Cretaceous Ringbone Formation, southwestern New Mexico显示文摘 | Anderson B G Barrick R E Lucas S G | 1998 | Joumal of Vertebrate Paleontology1998，18，： | 1 |
| 8 | Phenolic ripeness assessment of grape skin by texture analysis 显示文摘 | SUSANA R S LUCA R VINCENZO G | 2008 | Journal of Food Composition and Analysis2008，21，8： | 1 |
| 9 | Assessment of polymeric flocculants in oily water systems显示文摘 | Gonzalez G Lucas E F | 2005 | Colloid Polym Sci2005，283，： | 1 |
| 10 | The draft genome of watermelon (Citrullus lanatus ) and reseqnencing of 20 diverse accessions显示文摘 | Guo S G Zhang J G Sun H H Salse J Lucas W J Zhang H Y Zheng Y Mao L Y Ren Y WangZ W Min J M Guo X S Murat F Ham B K Zhang Z L Gao S Huang M Xu Y M Zhong S L Bombarely A Mueller L Zhao H He H Q Zhang Y Zhang Z H Huang S W Tan T Pang E Lin K Hu Q Kuang H H Ni P X Wang B Liu J G Kou Q H Hou W J Zou X H Jiang J Gong G Y Klee K Schoof H Huang Y Hu X S Dong S S Liang D Q Wang J Wu K Xia Y Zhao X Zheng Z Q Xing M Liang X M Huang B Q Lv T Wang J Y Yin Y Yi H P Li R Q Wu M Z Levi A Zhang X P Giovannoni J Wang J Li YF Fei Z J Xu Y | 2013 | Nature genetics2013，45，1： | 1 |
| 11 | In vitro generated anti-tumor T lymphocytes exhibit distinct subsets mimicking in vivo antigen- experienced cells 显示文摘 | Yang S Gattinoni L Luca G | 2011 | Cancer Immunol Immunother2011，60，5： | 1 |
| 12 | Recipient-derived HPA-1a antibodies: a cause of prolonged thrombocytopenia af- ter unrelated donor stem cell transplantation 显示文摘 | Lucas G Culliford S Green F | 2010 | Transfusion2010，50，2： | 1 |
| 13 | Characteristics of rice husks for chlorination reaction显示文摘 | ANDREOLI M LUCA G T MIYAMARU S E S | 2000 | Mater Lett2000，44，1： | 1 |
| 14 | Towards a phase-distribution independent impedance volume-fraction measurement 显示文摘 | Lucas G P Simonian S | 1991 | Flow Measurement and Instrumentation1991，2，2： | 1 |
| 15 | Towards a Phase-distribution Independent Impedance Volume-fraction Measurement显示文摘 | Lucas G P Simonian S | 1991 | Flow Measurement and Instrumentation1991，2，2： | 1 |
| 16 | CCR2 recruits an inflam-matory macrophage subpopulation critical for angiogenesis in tissuerepair显示文摘 | Willenborg S Lucas T van Loo G | 2012 | Blood2012，120，3： | 1 |
| 17 | Effects of intrauterine food restriction and long-term dietary supple mentation with L-arginine on age-related changes in renal function and structure of rats 显示文摘 | Gil F Z Lucas S R Gomes G N | 2005 | Pediatr Res2005，57，51： | 1 |
| 18 | Thermal investigations of direct iron ore reduction with coal显示文摘 | Liu G S Strezo V Lucas J A | 2004 | Thermochimica Acta2004，410，1： | 1 |
| 19 | The genome of the cucumber显示文摘 | HUANG S LI R ZHANG Z LI L GU X FAN W LUCAS W J WANG X XIE B NI P REN Y ZHU H LI J LIN K JIN W FEI Z LI G STAUB J KILIAN A VAN DER VOSSEN EA WUY GUO J HE J JIA Z REN Y TIAN G LU Y RUAN J QIANW WANG M HUANG Q LI B XUAN Z CAO J ASAN WUZ ZHANG J CAI Q BAI Y ZHAO B HAN Y LI Y LI X WANG S SHI Q LIU S CHO WK KIM JY XU Y HELLER-USZYNSKA K MIAO H CHENG Z ZHANG S WU J YANG Y KANG H LI M LIANG H REN X SHI Z WEN M JIAN M YANG H ZHANG G YANG Z CHEN R LIU S LI J MA L LIU H ZHOU Y ZHAO J FANG X LI G FANG L LI Y LIUD ZHENG H ZHANG Y QIN N LI Z YANG G YANG S BOLUND L KRISTIANSEN K ZHENG H LI S ZHANG X YANG H WANG J SUN R ZHANG B JIANG S WANG J DUY LI S | 2009 | Cucumis Sativus L NatureGenetics2009，41，： | 1 |
| 20 | Neural network modeling and control for underwater vehicles显示文摘 | KODOGIANNIS V S LISBOA P J G LUCAS J | 1996 | Artificial intelligence in Engineering1996，10，3： | 1 |
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