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| 1 | Use of butyrate or glutamine in enema solution reduces inflammation and fibrosis in experimental diversion colitis显示文摘AIM:To investigate whether butyrate or glutamine enemas could diminish inflammation in experimental diversion colitis.METHODS:Wistar specific pathogen-free rats were submitted to a Hartmann's end colostomy and treated with enemas containing glutamine,butyrate,or saline.Enemas were administered twice a week in the excluded segment of the colon from 4 to 12 wk after the surgical procedure.Follow-up colonoscopy was performed every 4 wk for 12 wk.The effect of treatment was evaluated using video-endoscopic and histologic scores and measuring interleukin-1β,tumor necrosis factor-alpha,and transforming growth factor beta production in organ cultures by enzyme linked immunosorbent assay.RESULTS:Colonoscopies of the diverted segment showed mucosa with hyperemia,increased number of vessels,bleeding and mucus discharge.Treatment with either glutamine or butyrate induced significant reductions in both colonoscopic(P < 0.02) and histological scores(P < 0.01) and restored the densities of collagen fibers in tissue(P = 0.015;P = 0.001),the number of goblet cells(P = 0.021;P = 0.029),and the rate of apoptosis within the epithelium(P = 0.043;P = 0.011) to normal values.The high levels of cytokines in colon explants from rats with diversion colitis significantly decreased to normal values after treatment with butyrate or glutamine.CONCLUSION:The improvement of experimental diversion colitis following glutamine or butyrate enemas highlights the importance of specific luminal nutrients in the homeostasis of the colonic mucosa and supports their utilization for the treatment of human diversion colitis. | Rodrigo Goulart Pacheco Christiano Costa Esposito Lucas CM Müller Morgana TL Castelo-Branco Leonardo Pereira Quintella Vera Lucia A Chagas Heitor Siffert P de Souza Alberto Schanaider | 2012 | World Journal of Gastroenterology2012，18，32： | 9 |
| 2 | Is autoimmune hepatitis a frequent finding among HCV patients with intense interface hepatitis?显示文摘AIM:To evaluate the overlap of autoimmune hepatitis in hepatitis C virus(HCV)-infected patients with intense interface hepatitis.METHODS:Among 1759 patients with hepatitis C submitted to liver biopsy,92(5.2%) presented intense interface hepatitis.These patients were evaluated regarding the presence of antinuclear antibody(ANA),anti-smooth muscle antibody(SMA) and anti-liver/kidney microsomal antibody(LKM-1),levels of γ-globulin and histological findings related to autoimmune hepatitis(plasma cell infiltrate and presence of rosettes).RESULTS:Among patients with hepatitis C and intense interface hepatitis there was a low prevalence of autoantibodies(ANA=12%,SMA=5%,LKM-1=0%) and the median γ-globulin level was within the normal range.Typical histological findings of autoimmune disease were observed in only two cases(2%).After applying the score for diagnosis of autoimmune hepatitis,only one patient was classified with a definitive diagnosis of autoimmune hepatitis.Since overlap with autoimmune hepatitis was not the explanation for the intense necroinflammatory activity in patients with chronic hepatitis C we sought to identify the variables associated with this finding.The presence of intense interface hepatitis was associated with more advanced age,both at the time of infection and at the time of the biopsy,and higher prevalence of blood transfusion and alcohol abuse.CONCLUSION:Although possible,overlap with autoimmune hepatitis is a very rare association in HCV-infected patients with intense interface hepatitis,an unusual presentation which seems to be related to other host variables. | Rosilene G Badiani Vitória Becker Renata M Perez Carla AL Matos Lara B Lemos Valéria P Lanzoni Luis Eduardo C Andrade Alessandra Dellavance Antonio Eduardo B Silva Maria Lucia G Ferraz | 2010 | World Journal of Gastroenterology2010，16，29： | 7 |
| 3 | Identification and expansion of human colon-cancer-initiating cells显示文摘 | LUCIA R V DARIO G L EMANUELA P | 2007 | Nature2007，445，： | 1 |
| 4 | Erythropoietin inhibits basal and stimulated corticotropin-releasing hormone release from the rat hypothalamus via a nontranscriptional mechanism显示文摘 | Giacomo P Lucia L Pierluigi N | 2007 | Endocrinology2007，148，10： | 1 |
| 5 | Determination of dimethyl fumarate and other potential allergens in desiccant and antimould sachets显示文摘 | LAMAS J P LUCIA S P REGUEIRO J | 2009 | Anal Bioanal Chem2009，394，8： | 1 |
| 6 | Inverted repeat PCR for the rapid assembly of constructs to induce RNA interference显示文摘 | Lucia C P Roger B D Elizabeth C | 2005 | Plant and Cell Physiology2005，46，11： | 1 |
| 7 | Comparison and development of new graph-based landscape connectivity indices: towards the prioritization of habitat patches and corridors for conservation显示文摘 | LUCIA P H SANTIAGO S | 2006 | Landscape Ecology2006，21，： | 1 |
| 8 | A self-organizing approach to background subtraction for visual surveillance applications 显示文摘 | Lucia M Alfredo P | 2008 | IEEE Transactions on IP2008，17，7： | 1 |
| 9 | Brugada Phenocopy in a Patient with Pectus Excavatum: Systematic Review of the ECG Manifestations Associated with Pectus Excavatum显示文摘 | Sara F.M. Awad Raimundo Barbosa‐Barros Lucia de Sousa Belem Camila Pinto Cavalcante Andrés Ricardo Pérez Riera Javier Garcia‐Niebla Daniel D. Anselm Adrian Baranchuk | 2013 | Annals of Noninvasive Electrocardiology2013，，5： | 1 |
| 10 | Brain cancer immunoediting:novel examples provided by immunotherapy of malignant gliomas显示文摘 | Serena P Lucia C Gaetano F | | 0，，11： | 1 |
| 11 | Guidelines for reporting of biocatalytic reactions 显示文摘 | LUCIA G POULSEN P B ANTONIO B | 2010 | Trends in Biotechnology2010，28，4： | 1 |
| 12 | A new habitat availability index to integrate connectivity in landscape conservation planning: Comparison with existing indices and application to a case study显示文摘 | SANTIAGO S LUCIA P H | 2007 | Landscape and Urban Planning2007，，： | 1 |
| 13 | A vision-based particle tracking velocimetry显示文摘 | Lucia M De Nesi P | 2001 | Real-Time Imaging2001，7，2： | 1 |
| 14 | Beta2- agonists prevent Th1 development by selective inhibition of interleukin-12显示文摘 | Panina-Bordignon P Mazzeo D Lucia PD | 1997 | J Clin Invest1997，100，6： | 1 |
| 15 | Reduced-order model ing new approaches for computational physics显示文摘 | Lucia D J Beran P S Silva W A | 2004 | Pro- gress in Aerospace Sciences2004，40，： | 1 |
| 16 | A self-organizing approach to background subtraction for visual surveillance applications 显示文摘 | Lucia M Alfredo P | 2008 | IEEE Transactions on Image Processing2008，17，7： | 1 |
| 17 | Microwave electrodynamics of electron-doped cuprate superconductors显示文摘 | Kokales J David Fournier P Mercaldo Lucia V | 2000 | Phys Rev Lett2000，85，： | 1 |
| 18 | Constituents and purgative activity of fruits of Alternanthera pungens 显示文摘 | Calderon Claudia P Garcia Aseff Susana B Fuentes Lucia B | 1996 | Acta Farmaceutica Bonaerense1996，15，3： | 1 |
| 19 | Impact of spatial scale on the identification of critical habitat patches for the maintenance of landscape connectivity显示文摘 | LUCIA P H SANTIAGO S | 2007 | Landscape and Urban Planning2007，，： | 1 |
| 20 | Monitoring the photochemical degradation of triclosan in wastewater by UV light and sunlight using solid-phase microextraction 显示文摘 | LUCIA S P MARIA L MARTA L | 2006 | Chemosphere2006，65，8： | 1 |
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