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| 1 | Intravenous immune globulin suppresses angiogenesis in mice and humans显示文摘Human intravenous immune globulin(IVIg),a purified IgG fraction composed of~60%IgG1 and obtained from the pooled plasma of thousands of donors,is clinically used for a wide range of diseases.The biological actions of IVIg are incompletely understood and have been attributed both to the polyclonal antibodies therein and also to their IgG(IgG)Fc regions.Recently,we demonstrated that multiple therapeutic human IgG1 antibodies suppress angiogenesis in a target-independent manner via FcγRI,a high-affinity receptor for IgG1.Here we show that IVIg possesses similar anti-angiogenic activity and inhibited blood vessel growth in five different mouse models of prevalent human diseases,namely,neovascular age-related macular degeneration,corneal neovascularization,colorectal cancer,fibrosarcoma and peripheral arterial ischemic disease.Angioinhibition was mediated by the Fc region of IVIg,required FcγRI and had similar potency in transgenic mice expressing human FcγRs.Finally,IVIg therapy administered to humans for the treatment of inflammatory or autoimmune diseases reduced kidney and muscle blood vessel densities.These data place IVIg,an agent approved by the US Food and Drug Administration,as a novel angioinhibitory drug in doses that are currently administered in the clinical setting.In addition,they raise the possibility of an unintended effect of IVIg on blood vessels. | Reo Yasuma Valeria Cicatiello Takeshi Mizutani Laura Tudisco Younghee Kim Valeria Tarallo Sasha Bogdanovich Yoshio Hirano Nagaraj Kerur Shengjian Li Tetsuhiro Yasuma Benjamin J Fowler Charles B Wright Ivana Apicella Adelaide Greco Arturo Brunetti Balamurali K Ambati Sevim Barbasso Helmers Ingrid E Lundberg Ondrej Viklicky Jeanette HW Leusen J Sjef Verbeek Bradley D Gelfand Ana Bastos-Carvalho Sandro De Falco Jayakrishna Ambati | 2016 | Signal Transduction and Targeted Therapy2016，1，1： | 3 |
| 2 | Preparation of calcium alginate nanoparticles using water-in-oil ( W/O ) nanoemulsions 显示文摘 | Machado AHE Lundberg D Ribeiro A J | 2012 | Langmuir: the ACS Journal of Surfaces and Colloids2012，28，9： | 1 |
| 3 | Photoluminescence imaging of speleothem microbanding with a high-resolution confocal scanning laser macroscope 显示文摘 | Ribes A Lundberg J Waldron D | 2000 | Quaternary International2000，6871，： | 1 |
| 4 | Temporal correlation of tumor necrosis factor-alpha release, up-regulation of pulmonary ICAM-1 and VCAM-I, neutrophil sequestration, and lung injury in diet-induced pancreatitis显示文摘 | Lundberg A H Grange D N Russell J | 2000 | J Gastrointes Surg2000，4，3： | 1 |
| 5 | Viscoelasticity and high shear rate viscosity in associative thickener formulations显示文摘 | Glass J E Lundberg D J | 1990 | Proe Wa- ter Borne Higher Solids Coat Symp1990，17，： | 1 |
| 6 | Viscoelasticity and high shear rate viscosityin associative thickener formulations显示文摘 | Glass J E Lundberg D J Ma Z | 1990 | Proc Water Borne Higher Solids Coat Symp1990，17，： | 1 |
| 7 | Fabrication of tungsten coatings and monoliths using the vacuum plasma spray process 显示文摘 | Varacalle D J Lundberg L B Jacox M G | 1993 | Surface and Coatings Technology1993，61，： | 1 |
| 8 | Elastomeric ionomer 显示文摘 | MacKnight W J Lundberg R D | 1984 | Rubb Chem Technol1984，57，3： | 1 |
| 9 | A pilot study ofthe antiemetic activity of olanzapine for the relief of nauseain patients with advanced cancer pain显示文摘 | Passik S D Lundberg J Kirsh K L | 2002 | J Pain SymptomManage2002，23，6： | 1 |
| 10 | Quantitative Measurement of P- and E-selectin Adhesion Molecules in Acute Pancreatitis:Correlation with Distant Organ Injury显示文摘 | Lundberg A H Granger D N Russell J | 2000 | Ann Surg2000，231，2： | 1 |
| 11 | Root system fibrosity ofSitka spruce transplants : relationship with root growth potential 显示文摘 | Deans J D Lundberg C Cannell M G R | 1990 | Forestry1990，63，1： | 1 |
| 12 | Quantitative Measurement of P- and E - Selectin Adbesion Molecules in Acute Panereatitis: Correlation With Distant Organ Injury显示文摘 | Lundberg A Granger D Russell J | 2000 | Anna Surg2000，231，2： | 1 |
| 13 | The transcriptional regulator AlgR is essential for Pseudomortas aeruginosa pathogenesis 显示文摘 | LIZEWSKI S E LUNDBERG D S SCHURR M J | 2002 | Infect Immun2002，70，11： | 1 |
| 14 | Synthesis, character ization, and solution rheology of model hydrophobically-modified water-soluble ethoxylated urethanes显示文摘 | Lundberg D J Brown R G Glass J E | 1994 | Langmuir1994，10，9： | 1 |
| 15 | The transcriptional regulator MgR is essential for Pseudomonas aeruginosa pathogenesis 显示文摘 | LIZEWSKI S E LUNDBERG D S SCHURR M J | 2002 | Infect Immun2002，70，： | 1 |
| 16 | Porous electrodes: concept,technology and results显示文摘 | Marcarter D J Lundberg KM Constjens JP | 1983 | PACE1983，6，22： | 1 |
| 17 | Elastomeric ionomers显示文摘 | Macknight W J Lundberg R D | 1984 | Rubber Chem Technol1984，57，3： | 1 |
| 18 | Quantitative measurement of P-and E-selectin adhesion molecules in acute pancreatitis:correlation with distant organ injury显示文摘 | LUNDBERG A H GRANGER D N RUSSELL J | 2000 | Ann Surg2000，231，2： | 1 |
| 19 | Titanium carbide coatings fabricated by the vacuum plasma spraying process 显示文摘 | Vracalle D J Lundberg L B Herman H | 1996 | Surface and Coatings Technology1996，，8687： | 1 |
| 20 | Graft modification of poly (vinyl chloride) and related reactions显示文摘 | LUNDBERG R D KENNEDY J P | 1972 | J Polym Sci:PartA-11972，10，： | 1 |
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