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| 1 | Role of matrix metalloproteinase,tissue inhibitor of metalloproteinase and tumor necrosis factor-α single nucleotide gene polymorphisms in inflammatory bowel disease显示文摘AIM:To study the (functional) relevance of single nucleotide polymorphisms (SNPs) in genes encoding matrix metalloproteinases (MMP)-1,-2,-3,-9,tissue inhibitors of metalloproteinases (TIMP)-1,-2 and tumor necrosis factor (TNF)-α in the etiopathogenesis of inflammatory bowel diseases (IBD),that may enhance susceptibility and/or disease severity. METHODS:Genomic DNA from 134 Crohn's disease (CD),111 ulcerative colitis (UC) patients and 248 control subjects was isolated from resected intestinal tissue or blood. Allelic composition at SNP loci was determined by PCR-RFLP or tetra primer ARMS PCR. RESULTS:The TIMP-1 genotype TT in women and T in men at SNP +372 T/C was found to increase CD susceptibility (39% vs 23.8%,P=0.018 and 67.9% vs 51.6%,P=0.055,respectively),while women with this genotype were less prone to development of fistulae during follow-up (41.4% vs 68.3%,P=0.025). Male IBD or CD patients carrying the TIMP-1 +372 T-allele expressed lower levels of TIMP-1 in surgically resected macroscopically inflamed tissue (0.065 < P < 0.01). The 5T5T genotype at MMP-3 SNP -1613 5T/6T increased the chance of stenotic complications in CD during follow-up (91.2% vs 71.8%,P = 0.022) but seemed to protect against colonic involvement of this disease at first endoscopic/radiologic examination (35.3% vs 59.5%,P=0.017). CONCLUSION:Allelic composition at the examinedSNPs in genes coding for TIMP-1 and MMP-3 affect CD susceptibility and/or phenotype,i.e.,fistulizing disease,stricture pathogenesis and first disease localisation. These findings reinforce the important role of these proteins in IBD. | Martin JW Meijer Marij AC Mieremet-Ooms Ruud A van Hogezand Cornelis BHW Lamers Daniel W Hommes Hein W Verspaget | 2007 | World Journal of Gastroenterology2007，13，21： | 15 |
| 2 | Library construction for next-generation sequencing: overviews and challenges 显示文摘 | HEAD S R KIYOMI K H LAMERE S A | 2014 | Biotechniques2014，56，2： | 1 |
| 3 | Influence of sorpriot, and diffusion of aroma compounds in silicone rubber on their extraction by pervaporation 显示文摘 | Lamer T Rohart M S Voilley A | 1994 | J Membr Sci1994，90，： | 1 |
| 4 | A role for di-acetyl alpha-melanocyte-stimulating hormone in the control of cor- tisol release in the teleost Oreochromis mossambicus显示文摘 | Lamers A E Flik G Atsma W | 1992 | JEndocrinol1992，135，2： | 1 |
| 5 | Hif-1 alpha expression is associated with an atheramatous inflam- matory plaque phenotype and upregulated in activated macrophages 显示文摘 | Yink A Schoneveld AH Lamers D | 2007 | Atherosclerosis2007，195，： | 1 |
| 6 | Modeling and calculation of turbulent lifted diffusion flames显示文摘 | LAMERS A P G G | 1994 | Combustion and Flame1994，96，： | 1 |
| 7 | Differential impact of oleate, palmitate, and adipokines on expression of NF-K B target genes in human vascular smooth muscle cells 显示文摘 | Lamers D Schlich R Horrighs A | 2012 | Mol Cell Endocrinol2012，362，2： | 1 |
| 8 | Control of soilborne plant pathogens by incorporating fresh organic amendments 显示文摘 | Blok W J Lamers J G Termorshuizen A J | 2000 | Phytopathology2000，90，： | 1 |
| 9 | Metabolomics in the context of systems biology:bridging traditional Chinese medicine and molecular pharmacology 显示文摘 | Wang M Lamers R J Korthout H A | 2005 | Phytother Res2005，19，3： | 1 |
| 10 | Angiotensin Ⅱ- mediated growth and antigrowth effects in cultured neonatal rat cardiac myocytes and fibroblasts 显示文摘 | van Kesteren C A van Heuqten H A Lamers J M | 1997 | J Mol Cell Cardiol1997，29，8： | 1 |
| 11 | Developing and implementing supply chain partnerships显示文摘 | Lamer D M Emmelhainz M A Gardner J T | 1996 | The International Journal of Logistics Management1996，7，2： | 1 |
| 12 | HIF-lalpha expression is associated with an atheromatous inflammatory plaque phenotype and upregulated in activa- ted macrophages 显示文摘 | Vink A Schoneveled AH Lamers D | 2007 | Atherosclerosis2007，195，2： | 1 |
| 13 | Pronominal Reference in Sentences About Personsor Things:an Electrophysiological Approach显示文摘 | Jansma B M Lamers M | 2005 | J Cogn Neurosci2005，17，： | 1 |
| 14 | Angiotensin Ⅱ - mdiated grwth and antigrowth effects incultured neonatal rat cardiac myocytes and fibroblasts显示文摘 | Van Kesteren C A M Van Heugten H A A Lamers J M J | 1997 | J Mol Cell Cardiol1997，29，： | 1 |
| 15 | Soil erosion and deposition effects on surface characteristics and pearl millet growth in the West African Sahel显示文摘 | A Buerkert J P A Lamers | 1995 | Plant and Soil1995，215，： | 1 |
| 16 | Treatment of metastaticrenal cell carcinoma with autologous T-lymphocytes geneticallyretargeted against carbonic anhydrase IX: first ciinicai experi-ence显示文摘 | Lamers C H Sleijfer S Vufto A G | 2006 | J Clin Oncol2006，24，13： | 1 |
| 17 | Broad-band Simultaneous Measurement of Complex Permittivity and Permeability Using a Coaxial Discontinuity显示文摘 | Eddine N Tahar B Lamer A | 1990 | IEEE Trans on MTT1990，38，1： | 1 |
| 18 | Effects of bombesin on the development of N-nitrosobis (2-oxopropyl) amine-induced pancreatic lesions in hamsters显示文摘 | Meijers M van Garderen-Hoetmer A Lamers CB | 1991 | Cancer Lett1991，59，1： | 1 |
| 19 | Treatment of metastatic renal cell carcinoma with autologous T-lymphocytes genetically retargeted against carbonic anhydrase IX: first clinical experience显示文摘 | Lamers C H Sleijfer S Vulto A G | 2006 | J Clin Oncol2006，24，13： | 1 |
| 20 | Red blood cell folate concentrations increase more after supplementation with[6S]-5-methyltetrahydrofolate than with folic acid in women of childbearing age显示文摘 | Lamers Y Prinz-Langenohl R Br(a)mswig S Pietrzik K | | 0，，： | 1 |
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