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| 1 | Influence of genes,sex,age and environment on the onset of autoimmune hepatitis显示文摘The pathogenesis of autoimmune hepatitis (AIH) is complex. However,it is believed that a susceptible individual,owing to his genetic background,sex and age,can develop the disease following exposure to an environmental trigger. Autoimmune hepatitis does not follow a Mendelian pattern of inheritance; hence no single causative genetic locus has been identified. However,several genes,inside and outside the HLA locus,have been linked to an increased susceptibility to AIH. Epidemiological evidence also suggests that the sex and age of the patient plays a role in AIH pathogenesis as the disease onset occurs mainly in the two first decades of life and a higher disease incidence is observed in females. No environmental trigger has been identified,but several have been proposed,mainly viruses and xenobiotics. This article aims at reviewing the current knowledge on susceptibility factors leading to AIH and putative triggers,emphasizing fundamental mechanisms responsible for the break of liver immunological tolerance. | Kathie Béland Pascal Lapierre Fernando Alvarez | 2009 | World Journal of Gastroenterology2009，15，9： | 8 |
| 2 | Characteriation of the difference of starch branching enzyme activities in nomal and low-amylopectin maize during kemel development显示文摘 | Sidebottom C Kirk land M Strongitham B | 1998 | Journal of Cereal Science1998，27，： | 1 |
| 3 | Parental assessments ofinternalizing and externalizing behavior and executive functionin children with primary hypertension显示文摘 | Lande MB Adams H Falkner B | | 0，，02： | 1 |
| 4 | Links Elevated Blood Pressure and Decreased Cognitive Function among Schod-age Children and Adolescents in the United States显示文摘 | Lande M B Kaczorowski J M Auinger P | 2003 | J Pediat2003，143，6： | 1 |
| 5 | Irregular variations in the melting point of size-selected atomic clusters显示文摘 | Schmidt M Kusche R von Issendorff B Haber- land H | 1998 | Nature1998，393，： | 1 |
| 6 | Inhibition of dipepti- dyl peptidase-4 reduces glycemia, sustains insulin levels, and reduces glucagon levels in type 2 diabetes 显示文摘 | Ahren B Land in-Olsson M Jansson P A | 2004 | JC lin Endocrino LM etab2004，89，5： | 1 |
| 7 | The frequency of urolithiasis in hospial discharge dagnoses in the United States显示文摘 | Sierakowski R Finlayson B Landes RR | 1978 | Invest Urol1978，15，： | 1 |
| 8 | Prevention of invasive breast cancer in women with ductal carcinoma in situ: an up- date of the National Surgical Adjuvant Breast and Bowel Proj- ect Experience显示文摘 | Fisher B Land S Mamounas E | 2001 | Semin Oncol2001，28，4： | 1 |
| 9 | Attachment,autonomy,and multifinality in adolescent internalizing and risky behavioral symptoms显示文摘 | McFarland F C Allen J P McElhaney K B Land D J | 2003 | Development and Psychopathology2003，15，： | 1 |
| 10 | Prospeetive evaluation of closed treatment of nondisplaced and nondislocated mandibular condyle fractures versus open reposition and rigid fixation of displaced and dislocated fractures in children显示文摘 | Landes CA Day K Glasl B | 2008 | J Oral Maxillofac Surg2008，66，6： | 1 |
| 11 | Biosynthesis of phenazine antibiotics in Streptomyces antibioticus:stereochemistry of methyl transfer from carbon-2 of acetate显示文摘 | McDonald M Wilkinson B Van't Land C W | 1999 | J Am Chem Soc1999，121，： | 1 |
| 12 | Matching an IT project with an appropriate method of evaluation:a research note on 'evaluating investments in IT' 显示文摘 | FARBEY B LAND F TARGETT D | 1994 | Journal of Information Technology1994，9，1： | 1 |
| 13 | Towards integrated coastal management in Solomon island: identify strategic issues for governance reform 显示文摘 | Marcus B Land | 2006 | Ocean & Coastal management2006，49，2： | 1 |
| 14 | the positive feedback of oestrogen, ovulation and luteal function in the ewe given bromcrip- tine to suppress proactin during seasonal an oestrus 显示文摘 | Land R B Carr W R McNeilliy A S | 1980 | Reprod Fertility1980，59，： | 1 |
| 15 | Single-stage Anatomical repair of complete atrioventricular canal,double-outlet right ventricle,and cor triatriatum using ventricular septal defect translocation显示文摘 | Tchervenkov C I Korkola S J Béland M J | 2002 | Ann Thorac Surg2002，73，4： | 1 |
| 16 | Ubiquitin : not just for proteasomes anymore 显示文摘 | Aguilar RC Wend land B | 2003 | Curr Opin Cell Biol2003，15，2： | 1 |
| 17 | Prevention of invasive breast cancer in women with ductal carcinoma in situ:an update of the national surgical adjuvant breast and bowel project experience显示文摘 | Fisher B Land S Mamounas E | 2001 | Semin Oncol2001，28，4： | 1 |
| 18 | Type 1-like immune response is found in children with respiratory syncytial virus infection regardless of clinical severity显示文摘 | Brandenburg AH Kleinjan A van Her Land B | 2000 | J Med Virol2000，62，： | 1 |
| 19 | The Binding Interface between Human APOBEC3F and HIV-1 Vif Elucidated by Genetic and Computational Approaches显示文摘 | Richards C Albin J S Demir O Shaban N M Luengas E M Land A M Anderson B D Holten J R Anderson J S Harki D A Amaro R E Harris R S | 2015 | Cell Rep2015，13，9： | 1 |
| 20 | Ocean particle chemistry: The fractionation of rare earth elements between suspended particles and seawater显示文摘 | Sholkovitz E R Landing W M Lewis B L | 1994 | Geochim Cosmochim Acta1994，58，6： | 1 |
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