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| 1 | Fecal microbes, short chain fatty acids, and colorectal cancer across racial/ethnic groups显示文摘AIM:To investigate differences in microbes and short chain fatty acid(SCFA) levels in stool samples from Hispanic and non-Hispanic African American,American Indian,and White participants.METHODS:Stool samples from twenty participants were subjected to analysis for relative levels of viable bacteria and for SCFA levels.Additionally,the samples were subjected to 16 S r RNA gene pyrosequencing for identification of bacteria present in the stool.We used a metagenome functional prediction technique to analyze genome copy numbers and estimate the abundance of butyrate kinase in all samples.RESULTS:We found that African Americans had significantly lower levels of acetate,butyrate,and total SCFAs than all other racial/ethnic groups.We also found that participant microbial profiles differed by racial/ethnic group.African Americans had significantly more Firmicutes than Whites,with enriched Ruminococcaceae.The Firmicutes /Bacteroidetes ratio was also significantly higher for African Americans than for Whites(P =0.049).We found Clostridium levels to be significantly and inversely related to total SCFA levels(P =0.019) and we found Bacteroides to be positively associated(P =0.027) and Clostridium to be negatively associated(P =0.012) with levels of butyrate.We also identified a correlation between copy number for a butyrate kinase predicted from 16 S r RNA gene abundance and levels of butyrate in stool.CONCLUSION:The identified differences in gut flora and SCFA levels may relate to colorectal cancer mortality differentials and may be useful as targets for future clinical and behavioral interventions. | Christina M Hester Venkatakrishna R Jala Morgan GI Langille Shahid Umar K Allen Greiner Bodduluri Haribabu | 2015 | World Journal of Gastroenterology2015，21，9： | 2 |
| 2 | Wall tissue remodeling regulates longitudenal tension in arteries显示文摘 | Jackson ZS Gotlieb AI Langille BL | 2002 | Circ Res2002，90，8： | 1 |
| 3 | Functional Dio geography of ocean microbes revealed through non-negative matrix factorization显示文摘 | Jiang X Langille M G Neches R Y | 2012 | PLoS One2012，7，43： | 1 |
| 4 | Apoptosis(programmed cell death) in arteries of the neonatal lamb显示文摘 | Cho A Courtman DW Langille BL | 1995 | Circ Res1995，76，2： | 1 |
| 5 | Adaptation of carotid arteries of young and mature rabbits to reduced carotid blood flow 显示文摘 | Langile BL Bendeck MP Keeley FW | 1989 | Am J Physiol1989，256，： | 1 |
| 6 | Seizures involving the supplementary sensorimotor area in children: a video-EEG analysis显示文摘 | Connolly MB Langill L Wong PK | 1995 | Epilesia1995，36，10： | 1 |
| 7 | Apotosis(programmed cell death)in arteries of the neonatal lamb显示文摘 | Cho A Court man DW Langille BL | 1995 | Circ Res1995，76，： | 1 |
| 8 | IslandViewer: an integrated interface for computational identification and visualization of genomic islands显示文摘 | Langille MGI Brinkman FSL | 2009 | Bioinformatics2009，25，5： | 1 |
| 9 | Remodeling Of developing and mature arteries:endothelium, smooth muscle, and matrix 显示文摘 | Langille BL | 1993 | J Cadiovasc Pharmacol1993，21，1： | 1 |
| 10 | Seizures involving the supplementary sensorimotor area in children:a Video-EEG analysis显示文摘 | Connolly M B Langill L Wong P K | 1995 | Epilesia1995，36，： | 1 |
| 11 | TSH signaling pathways that regulate MCP-1 in human differentiated adipocytes显示文摘 | Gagnon A Langille ML Chaker S | 2014 | Metabolism2014，63，6： | 1 |
| 12 | Permitting Pluralism: The Seal Products Dispute and Why the WTO Should Accept Trade Restrictions Justified By Noninstrumental Moral Values显示文摘 | Howse R Langille J | 2012 | Yale Journal International Law2012，，37： | 1 |
| 13 | Monocyte adhesion and changes in endothelial cell number, morphology, and F-actin distribution elicited by low shear stress in vivo显示文摘 | Walpola P L Gotlieb A I Langille B L | 1993 | Am J Pathol1993，142，5： | 1 |
| 14 | Spatial and temporal trends in soil properties at a soil quality benchmark site in central Scotia 显示文摘 | Webb K T Wang C Astatkie T Langille D R | 2000 | Canadian Journal of Soil Science2000，80，： | 1 |
| 15 | Apoptosis is in arteries of the neonatal lamb显示文摘 | HO A COURTMAN D W LANGILLE B L | 1995 | Circ Res1995，76，2： | 1 |
| 16 | Injury and repair of endothelium at sites of flow disturbances near abdominal aortic coarctations in rabbits显示文摘 | Langille BL Reidy MA Kline RL | 1986 | Arteriosclerosis1986，6，： | 1 |
| 17 | Predictive functional profiling of microbial communities using 16S rRNA marker gene sequences显示文摘 | Langille M G Zaneveld J Caporaso J G | 2013 | Nature Biotechnology2013，31，9： | 1 |
| 18 | Exploring the influence of a social ecological model on school-based physical activity 显示文摘 | Langille JL Rodgers WM | 2010 | Health Education and Behavior: the Official Publication of the Society for Public Health Education2010，37，6： | 1 |
| 19 | Exploring the Influence of a Social Ecological Model on School-Based Physical Activity显示文摘 | Langille J L Rodgers W M | 2010 | Health Educ Behav2010，37，6： | 1 |
| 20 | Reductions in arterial diameter produced by chronic decreases in blood flow are endothelium-dependent显示文摘 | Langille BL O'Donnell F | 1986 | Science1986，231，4736： | 1 |
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