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| 1 | Prognostic implications of hyperlaetatemia,multiple organ failure, and systemic inflammatory response syndrome in patients with acetaminophen-induced acute liver failure显示文摘 | Cmidt LE Larsen FS | 2006 | Crit Care Med2006，34，2： | 1 |
| 2 | Pathogenesis of Ebo- la hemorrhagic fever in Cynomolgus macaques: evidence that dendritic cells are early and sustained targets of infection 显示文摘 | Geisbert TW Hensley LE Larsen T | 2003 | Am J Pathol2003，163，6： | 1 |
| 3 | Metastatic pattern in non-resectable non-small cell lung cancer显示文摘 | Stenbygaard LE Sorensen JB Larsen H | 1999 | Acta Oncol1999，38，8： | 1 |
| 4 | Caspase-3/Caspase-acti- vated DNase promote cell differentiation by inducing DNA strand breaks显示文摘 | Larsen BD Rampalli S Burns LE | 2010 | Proe Natl Aead Sei USA2010，107，9： | 1 |
| 5 | Pathogenesis of Ebola haemorrhagic fever in cynomolgus macaques: evidence that dendritic cells are early and sustained targets of infection显示文摘 | Geisbert TW Hensley LE Larsen T | 2003 | Am J Pathol2003，163，： | 1 |
| 6 | Eftfect of exercise training on interleukin-6, tumour necrosis factor alpha and function- al capacity in heart failure 显示文摘 | Smart NA Larsen AI Le Maitre JP Ferraz AS | 2011 | Cardiol Res Pract2011，27，53： | 1 |
| 7 | Pathogenesis of Ebo- la hemorrhagic fever in cynomolgus macaques: evidence that den- dritic cells are early and sustained targets of infection显示文摘 | Geisbert TW Hensley LE Larsen T | 2003 | Am J Pathol2003，163，6： | 1 |
| 8 | Prognostic implications of hyperlactatemia, multiple organ failure, and systemic inflammatory response syndrome in patients with acetaminophen-induced acute liver failure 显示文摘 | Schmidt LE Larsen FS | 2006 | Crit Care Med2006，34，2： | 1 |
| 9 | Anomalies of the coronary arteries originating from the right sinus of Valsalva显示文摘 | Alf Inge Larsen Stein ?rn St?le Barvik Dennis W.T. Nilsen | 2006 | International Journal of Cardiology2006，，2： | 1 |
| 10 | FOLFIRI3-aflibercept in previously treated patients with metastatic colorectal cancer显示文摘AIM To evaluate the efficacy and safety of the modified FOLFIRI3-aflibercept as second-line therapy in patients with metastatic colorectal cancer.METHODS This is a retrospective multicenter cohort, evaluating the efficacy and safety of the association of aflibercept with FOLFIRI3(day 1: aflibercept 4 mg/kg, folinic acid 400 mg/m^2, irinotecan 90 mg/m^2, 5-fluorouracil infusion 2400 mg/m^2 per 46 h; day 3: irinotecan 90 mg/m^2) in patients with previously treated metastatic colorectal cancer. The primary endpoint was overall response rate(ORR). Secondary endpoints were disease control rate(DCR), progression-free survival(PFS), overall survival(OS), and safety.RESULTS Among 74 patients treated in four French centers, nine were excluded due to prior use of aflibercept(n = 3), more than one prior treatment line in irinotecanna?ve patients(n = 3), and inadequate liver function(n = 3). In the 'irinotecan-na?ve' patients(n = 30), ORR was 43.3% and DCR was 76.7%. Median PFS and OS were 11.3 mo(95%CI: 6.1-29.0) and 17.0 mo(95%CI: 13.0-17.3), respectively. The most common(> 5%) grade 3-4 adverse events were diarrhea(37.9%), neutropenia(14.3%), stomatitis and anemia(10.4%), and hypertension(6.7%). In the 'pre-exposed irinotecan' patients(n = 35), 20(57.1%) received ≥ 2 prior lines of treatment. ORR was 34.3% and DCR was 60.0%. Median PFS and OS were 5.7 mo(95%CI: 3.9-10.4) and 14.3 mo(95%CI: 12.8-19.5), respectively.CONCLUSION Minimally modified FOLFIRI has improvement dramatically the FOLFIRI3-aflibercept efficacy, whatever prior use of irinotecan. A prospective randomized trial is warranted to compare FOLFIRI-aflibercept to FOLFIRI3-aflibercept. | CANDice Carola Fran?ois Ghiringhelli Stefano Kim Thierry ANDré Juliette Barlet Le?la Bengrine-Lefevre Hélène Marijon Marie-Line Garcia-Larnicol Christophe Borg Linda Dainese Nils Steuer Hubert Richa Magdalena Benetkiewicz Annette K Larsen Aimery de Gramont Benoist Chibaudel | 2018 | World Journal of Clinical Oncology2018，9，5： | 1 |
| 11 | General toxicology of MnDPDP显示文摘 | Grant D | 1997 | Acta Radiol1997，38，4： | 1 |
| 12 | Caspase-3/caspase-activated DNase promote cell differentiation by inducing DNA strand breaks 显示文摘 | Larsen BD Rampalli S Burns LE | 2010 | PNAS2010，107，3： | 1 |
| 13 | Caspase3 -actrvated DNase promote cell differentiation by inducing DNA strand break 显示文摘 | Larsen BD Rampalli S Burns LE | 2010 | Proc Natl Acad Sei USA2010，107，9： | 1 |
| 14 | Pathogenesis of Ebola Haemorrhagic Fever in Cynomolgus Macaques: Evidence that Den- dritic Cells are Early and Sustained Targets of Infection 显示文摘 | Geisbert TW Hensley LE Larsen T | 2003 | Am J Pathol2003，163，： | 1 |
| 15 | Caspase - 3 actrvated DNase promote cell differentiation by inducing DNA strand break 显示文摘 | Larsen BD Rarnpalli S Burns LE | 2010 | Prec Natl Acad Sci USA2010，107，9： | 1 |
| 16 | Pathogenesis of Ebola hemorrhagic fever in eynomolgus macaques: evidence that dendritic cells are early and sustained targets of infection 显示文摘 | Geisbert TW Hensley LE Larsen T et 01 | 2003 | Am J Pathol2003，163，6： | 1 |
| 17 | Effect of exercise training on interleukin-6,tumour necrosis factor alpha and functional capacity in heart failure显示文摘 | Smart NA Larsen AI Le Maitre JP | 2011 | Cardiol Res Pract2011，2，7： | 1 |
| 18 | Pathogenesis of Ebola hemorrhagic fever in cynomolgus macaques:evidence that dendritic cells are early and sustained targets of infection显示文摘 | Geisbert TW Hensley LE Larsen T | 2003 | Am J Pathol2003，163，： | 1 |
| 19 | MELD score as a predictor of liver failure and death in patients with acetaminophen-induced liver injury显示文摘 | SCHMIDT LE LARSEN FS | 2007 | Hepatology2007，45，3： | 1 |
| 20 | Effect of Exercise Training on Interleukin -6,Tumour Necrosis Factor Alpha and Functional Capacity in Heart Failure 显示文摘 | Smart NA Larsen AI Le Maitre JP | 2011 | Cardiol Res Pract2011，，83： | 1 |
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