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| 1 | Comparative analysis of open and laparoscopic colectomy for malignancy in a developing country显示文摘AIM: To compare the short-term, including oncologic, outcomes of open vs laparoscopic colectomy for cancer in a developing country. METHODS: The records of patients who underwent elective open and laparoscopic colectomies for cancer at the University Hospital of the West Indies between January 2005 and December 2010 were retrospectively reviewed. Demographic(age, gender, Charlson comorbidity index score), peri-operative, post-operative and oncologic data were collected for each patient. Specific oncologic variables included lymph node yield, pathologic stage, grade, proximal, distal and circumferential margin involvement. Fisher's exact, Mann-Whitney, and binary logistic regression tests were used for analysis. Significance level was set atP < 0.05. RESULTS: There were 87 cases for open colectomy(OC) and 17 cases for laparoscopic colectomy(LC). Demographics did not significantly differ between OC and LC groups. Intra-operative blood loss and postoperative analgesic requirements did not significantly differ between groups. There was a trend towards longer operating times in OC group and shorter hospital stay in the LC group. Lymph node yield(14 vs 14, P = 0.619), proximal(10 cm vs 7 cm, P = 0.353) and distal(8 cm vs 8 cm, P = 0.57) resection margin distance and circumferential margin involvement(9 vs 0, P = 0.348) did not significantly differ between groups. Thirty-day morbidity was equivalent between groups(22 vs 6, P = 0.774). There were 6 deaths within 30 d of initial procedure, all in the OC group(6.9%). CONCLUSION: Laparoscopic colectomy in a developing country is oncologically safe and represents a option for colonic malignancies in these regions. Such data encourage the continued laparoscopic development. | Pierre-Anthony Leake Kristen Pitzul Patrick O Roberts Joseph M Plummer | 2013 | World Journal of Gastrointestinal Surgery2013，5，11： | 8 |
| 2 | Recent advances in the management of rectal cancer: No surgery, minimal surgery or minimally invasive surgery显示文摘Over the last decade,with the acceptance of the need for improvements in the outcome of patients affected with rectal cancer,there has been a significant increase in the literature regarding treatment options available to patients affected by this disease.That treatment related decisions should be made at a high volume multidisciplinary tumor board,after pre-operative rectal magnetic resonance imaging and the importance of total mesorectal excision(TME)are accepted standard of care.More controversial is the emerging role for watchful waiting rather than radical surgery in complete pathologic responders,which may be appropriate in 20%of patients.Patients with early T1 rectal cancers and favorable pathologic features can be cured with local excision only,with transanal minimal invasive surgery(TAMIS)because of its versatility and almost universal availability of the necessary equipment and skillset in the average laparoscopic surgeon,emerging as the leading option.Recent trials have raised concerns about the oncologic outcomes of the standard'top-down'TME hence transanal TME(Ta TME'bottom-up')approach has gained popularity as an alternative.The challenges are many,with a dearth of evidence of the oncologic superiority in the long-term for any given option.However,this review highlights recent advances in the role of chemoradiation only for complete pathologic responders,TAMIS for highly selected early rectal cancer patients and Ta TME as options to improve cure rates whilst maintaining quality of life in these patients,while we await the results of further definitive trials being currently conducted. | Joseph M Plummer Pierre-Anthony Leake Matthew R Albert | 2017 | World Journal of Gastrointestinal Surgery2017，9，6： | 6 |
| 3 | Brown rot fungal early stage decay mechanism as a biological pretreatment for softwood J biomass in biofuel production显示文摘 | Ray M J Leak D J Spanu P D | 2010 | Biomass and Bioenergy2010，34，8： | 1 |
| 4 | The behaviolal mede] h)r vulnerable populations: application to medical care use and outcomes for homeless people显示文摘 | Gelberg L Andersen R M Leake B 1) | 2000 | Health Serv Res2000，34，6： | 1 |
| 5 | Grain boundary diffusion of iron, co- balt and nickel in alpha-iron and of iron in gamma-iron 显示文摘 | James D W Leak G M | 1965 | Philosoplaical Magazine1965，12，17： | 1 |
| 6 | Euler/Navier-Stokes Anolysis of Vortical Flow about Rounded Leading Edge Delta Wing显示文摘 | H M Tsai C L Leak L Guarino | | AIAA0，95，： | 1 |
| 7 | Effect of nutrient limitation on product formation during continuous fermentation of xylose with Thermoanaerobacter ethanolicus JW200 Fe(7)显示文摘 | Hild H M Struckey D C Leak D J | 2003 | Appl Microbiol Biotechnol2003，60，： | 1 |
| 8 | Lymphangiogenesis in vitro: formation of lymphatic capillary-like channels from confluent monolayers of lymphatic endothelial cells显示文摘 | Leak LV Jones M | 1994 | In Vitro Cell Dev Biol1994，30，8： | 1 |
| 9 | Neurotrophic effects of GM1 ganglioside and electrical stimulation on cochlear spiralganglion neurons in cats deafened as neonates 显示文摘 | Leake PA Hradek GT Vollmer M | 2007 | The Journal of ComparativeNeurology2007，501，6： | 1 |
| 10 | The journey from safe yield to sustainability显示文摘 | Alley W M Leake S A | 2004 | Ground Water2004，42，1： | 1 |
| 11 | The Northwick Park Neck Pain Questionnaire, devised to measure neck pain and disability显示文摘 | Leak A M Cooper J Dyer S | 1994 | Br J Rheumatol1994，33，5： | 1 |
| 12 | Bryo- phyte physiological responses to, and recovery from, long- term nitrogen deposition and phosphorus fertiliza- tion in acidic grassland 显示文摘 | Arroniz Crespo M Leake J R Horton P | 2008 | New Phytologist2008，180，4： | 1 |
| 13 | Epithermal Gold Deposits of the Southwest Pacific 显示文摘 | White N C Leake M J McCaughey S N | 1995 | Journal of Geochemical Exploration1995，54，： | 1 |
| 14 | Lymphatic endothelium isolation and long term culture 显示文摘 | Leak LV Jones M | 1993 | Anat Rec1993，236，： | 1 |
| 15 | Vitamin C protects human arterial smooth muscle cells against atherogenic lipoproteins:effects of antioxidant vitamins on oxidized LDL-induced increases in cystin transport and glutathione 显示文摘 | SIOW R C M SATO H LEAKE D S | 1998 | Arterioscle Thromb Vasc Biol1998，18，： | 1 |
| 16 | Pathology of experimental autoimmunity in mice显示文摘 | Chan CC Caspi RR Ni M Leake WC Wiggert B Chader GJ Nussenblatt RB | 1990 | Autoimmun1990，3，： | 1 |
| 17 | Crescentic glomerulonephritis in children显示文摘 | JARDIM H M LEAKE J RISDON R A | 1992 | Pediatr Nephrol1992，6，3： | 1 |
| 18 | Gene transcripts associated with BMI in the motor cortex and caudate nucleus of calorie restricted rhesus monkeys 显示文摘 | Mitchell A C Leak R K Zigmond M J | 2012 | Genomics2012，99，3： | 1 |
| 19 | The journey from safe yield to sustainability显示文摘 | Alley W M Leake S A | 2004 | Ground Water2004，42，1： | 1 |
| 20 | OATP and P-glycoprotein transporters mediate the cellular uptake and excretion of Fexofenadine显示文摘 | Cvetkovic M Leake B Fromm MF | 1999 | Drug Metabolism and Disposition1999，27，： | 1 |
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