|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Receptor activator of NF-κB Ligand (RANKL) expression is associated with epithelial to mesenchymal transition in human prostate cancer cells显示文摘 | Valerie A Odero-Marah Ruoxiang Wang Gina Chu Majd Zayzafoon Jianchun Xu Chunmeng Shi Fray F Marshall Haiyen E Zhau Leland WK Chung | 2008 | Cell Research2008，18，8： | 6 |
| 2 | Regulatory signaling network in the tumor microenvironment of prostate cancer bone and visceral organ metastases and the development of novel therapeutics显示文摘This article describes cell signaling network of metastatic prostate cancer(PCa)to bone and visceral organs in the context of tumor microenvironment and for the development of novel therapeutics.The article focuses on our recent progress in the understanding of:1)The plasticity and dynamics of tumorestroma interaction;2)The significance of epigenetic reprogramming in conferring cancer growth,invasion and metastasis;3)New insights on altered junctional communication affecting PCa bone and brain metastases;4)Novel strategies to overcome therapeutic resistance to hormonal antagonists and chemotherapy;5)Geneticbased therapy to co-target tumor and bone stroma;6)PCa-bone-immune cell interaction and TBX2-WNTprotein signaling in bone metastasis;7)The roles of monoamine oxidase and reactive oxygen species in PCa growth and bone metastasis;and 8)Characterization of imprinting cluster of microRNA,in tumorestroma interaction.This article provides new approaches and insights of PCa metastases with emphasis on basic science and potential for clinical translation.This article referenced the details of the various approaches and discoveries described herein in peer-reviewed publications.We dedicate this article in our fond memory of Dr.Donald S.Coffey who taught us the spirit of sharing and the importance of focusing basic science discoveries toward translational medicine. | Gina Chia-Yi Chu Leland W.K.Chung Murali Gururajan Chia-Ling Hsieh Sajni Josson Srinivas Nandana Shian-Ying Sung Ruoxiang Wang Jason Boyang Wu Haiyen E.Zhau | 2019 | Asian Journal of Urology2019，6，1： | 5 |
| 3 | Manifold learning of four-dimensional scanning transmission electron microscopy显示文摘Four-dimensional scanning transmission electron microscopy(4D-STEM)of local atomic diffraction patterns is emerging as a powerful technique for probing intricate details of atomic structure and atomic electric fields.However,efficient processing and interpretation of large volumes of data remain challenging,especially for two-dimensional or light materials because the diffraction signal recorded on the pixelated arrays is weak.Here we employ data-driven manifold leaning approaches for straightforward visualization and exploration analysis of 4D-STEM datasets,distilling real-space neighboring effects on atomically resolved deflection patterns from single-layer graphene,with single dopant atoms,as recorded on a pixelated detector.These extracted patterns relate to both individual atom sites and sublattice structures,effectively discriminating single dopant anomalies via multimode views.We believe manifold learning analysis will accelerate physics discoveries coupled between data-rich imaging mechanisms and materials such as ferroelectric,topological spin,and van der Waals heterostructures. | Xin Li Ondrej E.Dyck Mark P.Oxley Andrew R.Lupini Leland McInnes John Healy Stephen Jesse Sergei V.Kalinin | 2019 | npj Computational Materials2019，，1： | 4 |
| 4 | sonic hedgehog信号通路蛋白在人胚胎前列腺发育不同阶段的表达及意义显示文摘目的:探明sonic hedgehog信号通路中几个关键的效应蛋白sonic hedgehog(SHH)、Patchedl(PTC1)、Smoothened(SMO)及GLI1在人胚胎前列腺组织中的定位表达及变化.方法:应用免疫组织化学方法研究SHH、PTC1、SMO及GLI1在不同胎龄(10~39周)人胚胎前列腺组织中的表达变化情况.结果:随胎龄增大,SHH、PTC1、SMO及GLI1在前列腺组织中的表达水平呈由弱变强,由强渐弱,又由弱转强的双峰变化趋势.SHH和SMO仅表达在胚胎前列腺上皮细胞中;而PTC1和GLI1主要表达在上皮细胞外,也可表达在腺体周围的间质中.结论:SHH信号通路参与了人胚胎前列腺发育的调控过程,可能对于腺体发育初期的诱导发生,以及后期的增殖、分化都具有重要的调控作用. | 朱国栋 贺大林 何辉 张林琳 王新阳 Zhau E Haiyen Chung Leland WK | 2006 | 中华男科学杂志2006，12，10： | 4 |
| 5 | 前列腺基底细胞增生显示文摘尽管目前在中国前列腺癌的发病率明显低于美国[1~3],但对容易误诊的病变不应忽视。前列腺基底细胞增生(basalcelhyperplasia,BCH)是少见的良性增生性疾病,而其重要性在于可能与腺癌混淆[4,5],无论是普查穿刺的小标本,还是根治性手... | 杨华 HAIYEN E.ZHAU HENRY FRISON LELAND W.K.CHUNG | 1998 | 中华病理学杂志1998，27，6： | 4 |
| 6 | Overexpression of the promyelocytic leukemia gene suppresses growth of human bladder cancer cells by inducing Gl cell cycle arrest and apoptosis显示文摘Objectives To examine the anti-oncogenic effects of promyelocytic leukemia (PML) on bladder cancer and to explore its molecular mechanisms of growth suppression.Methods Wild-type PML was transfected into bladder cancer cells (5637 cell) and expressed in a replication-deficient adenovirus-mediated gene delivery system and introduced into human bladder cancer cells (5637 cell ) in vitro and in vivo. The effect and mechanisms of the PML gene in cell growth, clonogenicity, and tumorigenicity of bladder cancer cells were studied using in vitro and in vivo growth assays, soft agar colony-forming assay, cell cycle analysis, apoptosis assay and in vivo tumorigenicity assay.Results Overexpression of PML in 5637 cells significantly reduced their growth rate and clonogenicity on soft agar. PML suppressed bladder cancer cell growth by inducing G1 cell cycle arrest and apoptosis. Adenovirus-mediated PML (Ad-PML) significantly suppressed the tumorigenicity and growth of bladder cancer cells. Intratumoral injection of Ad-PML into tumors induced by 5637 cells dramatically suppressed their growth.Conclusions The results indicated that overexpression of PML protein may promote efficient growth inhibition of human bladder cancer cells by inducing G1 cell cycle arrest and apoptosis, and adenovirus-mediated PML (Ad-PML) expression efficiently suppresses human bladder cancer growth. | 贺大林 南勋义 Chang Kun-Song 王亚峰 Chung Leland W.K. | 2003 | Chinese Medical Journal2003，，9： | 4 |
| 7 | Interracial differences in prostate cancer progression among patients from the United States, China and Japan显示文摘 | Haiyen E Zhau Qinlong Li Leland WK Chung | 2013 | Asian Journal of Andrology2013，15，6： | 2 |
| 8 | Corporate Giving Behavior and Decision-Maker Social Consciousness显示文摘 | Leland Campbell Charles S. Gulas Thomas S. Gruca | 1999 | Journal of Business Ethics1999，，4： | 2 |
| 9 | Cultured circulating tumor cells and their derived xenografts for personalized oncology显示文摘Recent cancer research has demonstrated the existence of circulating tumor cells(CTCs)in cancer patient’s blood.Once identified,CTC biomarkers will be invaluable tools for clinical diagnosis,prognosis and treatment.In this review,we propose ex vivo culture as a rational strategy for large scale amplification of the limited numbers of CTCs from a patient sample,to derive enough CTCs for accurate and reproducible characterization of the biophysical,biochemical,gene expressional and behavioral properties of the harvested cells.Because of tumor cell heterogeneity,it is important to amplify all the CTCs in a blood sample for a comprehensive understanding of their role in cancer metastasis.By analyzing critical steps and technical issues in ex vivo CTC culture,we developed a cost-effective and reproducible protocol directly culturing whole peripheral blood mononuclear cells,relying on an assumed survival advantage in CTCs and CTC-like cells over the normal cells to amplify this specified cluster of cancer cells. | Ruoxiang Wang Gina CYChu Stefan Mrdenovic Alagappan A.Annamalai Andrew E.Hendifar Nicholas N.Nissen James S.Tomlinson Michael Lewis Nallasivam Palanisamy Hsian-Rong Tseng Edwin M.Posadas Michael R.Freeman Stephen J.Pandol Haiyen E.Zhau Leland W.K.Chung | 2016 | Asian Journal of Urology2016，3，4： | 2 |
| 10 | 波形蛋白、细胞角蛋白5,18,19在人胚胎前列腺发育不同阶段的表达及意义显示文摘目的探讨波形蛋白(Vimentin),细胞角蛋白(Cytokeratin)5、18、19(CK5、18、19)在人胚胎前列腺发育不同阶段组织及细胞中的定位表达变化及其在前列腺胚胎发育中的意义。方法应用免疫组织化学方法研究Vimentin、CK5、CK18、CK19在不同胎龄前列腺组织中的表达变化。结果胚胎前列腺上皮细胞中波形蛋白随胎龄增大其表达呈由弱到强,又由强减弱的变化趋势;CK5和CK18的表达起初分布无规律,但是随胎龄增大,CK5和CK18逐渐分别定位表达于基底细胞层和管腔上皮细胞层;CK19则在基底细胞层和管腔上皮细胞层中均有表达,且强度较一致,基本不随胎龄增大而变化。结论胚胎前列腺上皮细胞Vimentin的表达,可能有助于上皮细胞的游走迁移,以形成早期原始腺体。CK5、CK18以及CK19阳性细胞在原始腺体中的动态分布与胚胎前列腺上皮细胞的分化状态有关。 | 何辉 朱国栋 宁亮 Zhau E.Haiyen Chung Leland WK 贺大林 南勋义 | 2006 | 现代泌尿外科杂志2006，11，2： | 2 |
| 11 | On the self-similar nature of E thernet traffic (extended version)显示文摘 | Leland W E Taqqu M S Willinger Wetal | 1994 | IEEE/ACM Transactions on Networking1994，2，1： | 2 |
| 12 | On the self-similar nature of Ethernet traffic (extended version)显示文摘 | Will E. Leland Murad S. Taqqu Walter Willinger Daniel V. Wilson | 1994 | IEEE/ACM Transactions on Networking (TON)1994，，1： | 2 |
| 13 | Vibrating pervaporation modules:Effect of module design on performance显示文摘 | LELAND M V FRANKLIN R A | 2005 | J Membr Sci2005，255，： | 1 |
| 14 | Informational Asymmetries, Financial Structure, and Financial Intermediation 显示文摘 | Leland H E Pyle D H | 1977 | Journal of Finance1977，，32： | 1 |
| 15 | On the self-similar uatare of ethernet traffic (extended versioa)显示文摘 | LELAND W E TAQQU M S WILLINGER W | 1994 | IEEE/ACM Transactions on Networking1994，2，： | 1 |
| 16 | Agency costs, risk management, and capital structure显示文摘 | Leland H | 1998 | Journal of Finance1998，53，4： | 1 |
| 17 | On the self-similar nature of Ethcrnet traffic (extended vcrsion)显示文摘 | LELAND W E TAQQU M S WILLINGER W | 1994 | IEEE/ACM Trans on Networking1994，2，1： | 1 |
| 18 | On the self-similar nature of Ethernet traffic显示文摘 | Leland W E Taqqu M S Willinger W and Wilson D V | 1994 | IEEE/ACM Transactions on Networking1994，2，1： | 1 |
| 19 | On the Self-similar Nature of Ethernet Traffic显示文摘 | Leland W E Taqqu M S Willinger W | 1994 | IEEE/ACM Transactions on Networking1994，2，1： | 1 |
| 20 | Incision and diferen-tial bedrock uplift along the Indus River near Nanga Parbal,Pakistan Himalaya,from 10Be and 26Al exposure age dating of bedrock straths 显示文摘 | Leland J Reid M R Burbank D W | 1998 | Earth and Planetary Science Letters1998，154，14： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员