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| 1 | Endovascular treatment with or without intravenous alteplase for acute ischaemic stroke due to basilar artery occlusion显示文摘Background and purpose It remains controversial if endovascular treatment(EVT)can improve the outcome of patients with acute basilar artery occlusion(BAO).This study aims to compare the functional outcomes between EVT with and without intravenous thrombolysis(IVT)first in patients who had acute ischaemic stroke(AIS)due to BAO.Methods Patients who had AIS with BAO who underwent EVT within 24 hours of onset were enrolled in this multicentre cohort study,and the efficacy and safety were compared between IVT+EVT and direct EVT.The primary outcome was 90-day functional independence.All outcomes were assessed with adjusted OR(aOR)from the multivariable logistic regression.In addition,a meta-analysis was performed on all recently published pivotal studies on functional independence after EVT in patients with BAO.Results Of 310 enrolled patients with BAO,241(78%)were treated with direct EVT and 69(22%)with IVT+EVT.Direct EVT was associated with a worse functional outcome(aOR,0.46(95%CI 0.24 to 0.85),p=0.01).IVT+EVT was associated with a lower percentage of patients who needed≥3 passes of stent retriever(10.14%vs 20.75%).The meta-analysis regression revealed a potential positive correlation between bridging with IVT first and functional independence(r=0.14(95%CI 0.05 to 0.24),p<0.01).Conclusions This study showed that compared with direct EVT,EVT with IVT first was associated with better functional outcomes in patients with BAO treated within 24 hours of onset.The meta-analysis demonstrated similar favourable efficacy of IVT first followed by EVT in patients with BAO. | Ximing Nie David Wang Yuehua Pu Yufei Wei Qixuan Lu Hongyi Yan Xin Liu Lina Zheng Jingyi Liu Xinxuan Yang Yarong Ding Dacheng Liu Wanying Duan Zhe Zhang Zhonghua Yang Miao Wen Weibin Gu Xinyi Hou Xinyi Leng Yuesong Pan Zhongrong Miao Liping Liu | 2022 | Stroke & Vascular Neurology2022，7，3： | 10 |
| 2 | Combining cold sintering and Bi_(2)O_(3)-Activated liquid-phase sintering to fabricate high-conductivity Mg-doped NASICON at reduced temperatures显示文摘The cold sintering process(CSP)and Bi_(2)O_(3)-activated liquid-phase sintering(LPS)are combined to densify Mg-doped NASICON(Na_(3.256)Mg_(0.128)Zr_(1.872)Si_(2)PO_(12))to achieve high densities and conductivities at reduced temperatures.As an example,a cold-sintered specimen with the addition of 1.1wt%Bi_(2)O_(3)sintering additive achieved a high conductivity of 0.91 mS/cm(with~96%relative density)after annealing at 1000℃;this conductivity is>70%higher than that of a cold-sintered specimen without adding the Bi_(2)O_(3)sintering additive,and it is>700%of the conductivity of a dry-pressed counterpart with the same amount of Bi_(2)O_(3)added,all of which are subjected to the same heating profile.The highest conductivity achieved in this study via combining CSP and Bi_(2)O_(3)-activated LSP is>1.5 mS/cm.This study suggests an opportunity to combine the new CSP with the traditional LPS to sinter solid electrolytes to achieve high densities and conductivities at reduced temperatures.This combined CSP-LPS approach can be extended to a broad range of other materials to fabricate the“thermally fragile”solid electrolytes or solid-state battery systems,where reducing the processing temperature is often desirable. | Haoyang Leng Jiuyuan Nie Jian Luo | 2019 | Journal of Materiomics2019，5，2： | 4 |
| 3 | Continuity Scaling: A Rigorous Framework for Detecting and Quantifying Causality Accurately显示文摘Data-based detection and quantification of causation in complex,nonlinear dynamical systems is of paramount importance to science,engineering,and beyond.Inspired by the widely used methodology in recent years,the cross-map-based techniques,we develop a general framework to advance towards a comprehensive understanding of dynamical causal mechanisms,which is consistent with the natural interpretation of causality.In particular,instead of measuring the smoothness of the cross-map as conventionally implemented,we define causation through measuring the scaling law for the continuity of the investigated dynamical system directly.The uncovered scaling law enables accurate,reliable,and eficient detection of causation and assessment of its strength in general complex dynamical systems,outperforming those existing representative methods.The continuity scaling-based framework is rigorously established and demonstrated using datasets from model complex systems and the real world. | Xiong Ying Si-Yang Leng Huan-Fei MaD Qing Nie Ying-Cheng Lai Wei Lin | 2022 | Research2022，，4： | 1 |
| 4 | Intrinsicperoxidase-like activity of ferromagnetic nanoparticles 显示文摘 | GAO Li-zeng ZHUANG Jie NIE Leng ZHANG Jin-bin ZHANG Yu GU Ning WANG Tai-hong FENG Jing YANGDong-ling PERRETT Sarah YAN Xi-yun | 2007 | Nature Nanotechnology2007，2，4： | 1 |
| 5 | Intrinsic peroxidase-like activity of ferromagnetic nanoparticles显示文摘 | GAO Li Zeng ZHUANG Jie NIE Leng | 2007 | Nat Nanotechnol2007，2，： | 1 |
| 6 | Intrinsic peroxidase-like activity of ferromagnetic nanoparticles 显示文摘 | Gao Lizeng Zhuang Jie Nie Leng | 2007 | Nature Nanotechnology2007，2，9： | 1 |
| 7 | Intrinsic peroxidase-like activity of ferromagnetic nanoparticles显示文摘 | Lizeng Gao Jie Zhuang Leng Nie | 2007 | Nature Nanotechnology2007，，2： | 1 |
| 8 | Intrinsic peroxidase-like activity of ferromagnetic nanoparticles显示文摘 | Gao Lizeng Zhuang Jie Nie Leng | 2007 | Nature Nanoteehnology2007，2，9： | 1 |
| 9 | Intrinsic peroxi- daseqike activity of ferromagnetic nanoparticles 显示文摘 | GAO Lizeng ZHUANG Jie NIE Leng | 2007 | Nature Nanotechnology2007，2，9： | 1 |
| 10 | Intrinsic peroxidase- like activity of ferromagnetic nanoparticles 显示文摘 | Gao Lizeng Zhuang Jie Nie Leng | 2007 | Nat Nanotechnol2007，2，9： | 1 |
| 11 | Intrinsic peroxidase -like activity of ferromagnetic nanoparticles显示文摘 | Gao Li-zeng Zhuang Jie Nie Leng | 2007 | Nature Nanotechnology2007，2，： | 1 |
| 12 | Elevated CXCL12 expression in the bone marrow of NOD mice is associated with altered T cell and stem cell trafficking and diabetes development显示文摘 | Leng Q Nie Y Zou Y | | 0，，： | 1 |
| 13 | In-situ characterizations of 1-200MHz radio-frequency signal coupling with human body 显示文摘 | NIE Z D LENG T F WANG W C | 2012 | Biomedical Engineering-Applications Basis Communications2012，24，3： | 1 |
| 14 | Intrinsic Peroxidase-Like Activity of Ferromagnetic Nanoparticles显示文摘 | Gao Lizeng Zhuang Jie Nie Leng | 2007 | Nat Nanotechnol2007，2，： | 1 |
| 15 | Intrinsic peroxidase-like activity of ferromagnetic nanoparticles显示文摘 | Gao Lizeng Zhuang Iie Nie Leng | 2007 | Nat Nanotechn2007，2，9： | 1 |
| 16 | Elevated CXCL12 expression in the bone marrow of NOD mice is associated with altered T cell and stem cell trafficking and diabetes development 显示文摘 | LENG Q NIE Y ZOU Y | 2008 | BMC Immunol2008，9，1： | 1 |
| 17 | Optimization of Supercritical Extraction Process of Laoshan Black Tea by Response Surface Methodology显示文摘[Objectives]Laoshan black tea was subjected to supercritical CO_(2) extraction. [Methods]The extraction conditions of Laoshan black tea were studied by an orthogonal experiment and optimized by response surface methodology. [Results] The optimum extraction conditions of black tea extract by supercritical CO_(2) extraction were as follows: extraction pressure 23.53 MPa, extraction time 1.73 h, and extraction temperature 49.75 ℃, with which the extract yield could reach 5.15% theoretically. [Conclusions] Based on the traditional extraction process, a supercritical extraction method optimized by response surface methodology and a unique extraction process were formed, which enriches the extraction processes and methods of natural raw materials. | Yongxin LIU Zhiguang LIU Zengyu WANG Shuai ZHANG Guofeng YU Jianhong SUN Shoutao CAO Qiulin LIU Xulun WEI Cuishu LENG Fuhua MA Xuegang LI Yinlong WANG Shoujie NIE | 2023 | Agricultural Biotechnology2023，12，1： | 0 |
| 18 | Variations in EXD3 caused congenital cataracts in three Chinese families显示文摘Congenital cataract is a clinically and genetically heterogeneous disease characterized by any opacity of the lens presenting at birth or in the first year of life,with an incidence of 1–6/10,000 live births in developed countries and 5–15/10,000 live births in developing countries.Congenital cataract accounts for 7.4%–15.5%of all childhood blindness,and it occurs as either a syndromic disease or an isolated(nonsyndromic)disease with or without other ocular malformations,such as microcornea. | Lihua Cao Yunji Leng Xinmiao Nie Shuyang Zhao Tianxiao Zhang | 2023 | Genes & Diseases2023，10，3： | 0 |
| 19 | Detection of Hepatitis B Virus M204V Mutation Quantitatively via Real-time PCR显示文摘Background and Aims:Drug-resistant DNA mutations of the hepatitis B virus(HBV)affect treatment response in chronic hepatitis B patients.We have established a new,sensitive,specific,accurate and convenient real-time PCR method to detect HBV mutations quantitatively.Methods:Blood samples were collected from patients showing viral breakthrough,primary nonresponse,or poor response during treatment,and mutations were detected via direct sequencing to assess our method.A plasmid containing the M204V mutation was synthesized and standard curves plotted.Results:The determination coefficient for linear correlation between Ct and log plasmid copy numbers was 0.996,where Ct value was−3.723log(DNA concentration)+48.647.Coefficients of variation indicated good reproducibility.Correctness was within tolerable bias.Limit of detection was 103 copies/mL.Specificity,accuracy,positive predictive value and negative predictive value were 92.86%,100%,96.88%,100%and 94.74%,respectively.Conclusions:These results show that our method can be used to detect HBV M204V mutations with the advantages of sensitivity,specificity and efficiency,providing a new choice for monitoring drug resistance. | Jingjing Liang Xinmiao Liang Hong Ma Leng Nie Ying Tian Guang Chen Yu Wang | 2021 | Journal of Clinical and Translational Hepatology2021，9，2： | 0 |
| 20 | The cannabis paradox:contrasting role for marijuana in cardiovascular disease显示文摘In a recent study published in Cell,Wei and colleagues describe the role of canabis in mediating inflammation and oxidative stress induced endothelial dysfunction and thereby contributing to the pathogenesis of atherosclerosis.1 Cardiovascular diseases(CVDs)are still the leading cause of death globally.There is an estimated 17.9 million people died from CVDs in 2019,representing 32%of all global deaths.2 Cannabis,also known as hemp or marijuana,is the most widely cultivated,trafficked and abused illicit drug worldwide especially in Western countries. | Lin Deng Bin Leng Xiaowei Nie | 2022 | Signal Transduction and Targeted Therapy2022，7，10： | 0 |
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