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| 1 | Risk stratification in symptomatic intracranial atherosclerotic disease with conventional vascular risk factors and cerebral haemodynamics显示文摘Background and purpose Symptomatic intracranial atherosclerotic stenosis(sICAS)is associated with a considerable risk of recurrent stroke despite contemporarily optimal medical treatment.Severity of luminal stenosis in sICAS and its haemodynamic significance quantified with computational fluid dynamics(CFD)models were associated with the risk of stroke recurrence.We aimed to develop and compare stroke risk prediction nomograms in sICAS,based on vascular risk factors and these metrics.Methods Patients with 50%-99%sICAS confirmed in CT angiography(CTA)were enrolled.Conventional vascular risk factors were collected.Severity of luminal stenosis in sICAS was dichotomised as moderate(50%-69%)and severe(70%-99%).Translesional pressure ratio(PR)and wall shear stress ratio(WSSR)were quantified via CTA-based CFD modelling;the haemodynamic status of sICAS was classified as normal(normal PR&WSSR),intermediate(otherwise)and abnormal(abnormal PR&WSSR).All patients received guideline-recommended medical treatment.We developed and compared performance of nomograms composed of these variables and independent predictors identified in multivariate logistic regression,in predicting the primary outcome,recurrent ischaemic stroke in the same territory(SIT)within 1 year.Results Among 245 sICAS patients,20(8.2%)had SIT.The D2H2A nomogram,incorporating diabetes,dyslipidaemia,haemodynamic status of sICAS,hypertension and age≥50 years,showed good calibration(P for Hosmer-Lemeshow test=0.560)and discrimination(C-statistic 0.73,95%CI 0.60 to 0.85).It also had better performance in risk reclassification and provided larger net benefits in decision curve analysis,compared with nomograms composed of conventional vascular risk factors only,and plus the severity of luminal stenosis in sICAS.Sensitivity analysis in patients with anterior-circulation sICAS showed similar results.Conclusions The D2H2A nomogram,incorporating conventional vascular risk factors and the haemodynamic significance of sICAS as assessed in CFD models,could be a useful tool to stratify sICAS patients for the risk of recurrent stroke under contemporarily optimal medical treatment. | Xuan Tian Hui Fang Linfang Lan Hing Lung Ip Jill Abrigo Haipeng Liu Lina Zheng Florence S Y Fan Sze Ho Ma Bonaventure Ip Bo Song Yuming Xu Jingwei Li Bing Zhang Yun Xu Yannie O Y Soo Vincent Mok Ka Sing Wong Thomas W Leung Xinyi Leng | 2023 | Stroke & Vascular Neurology2023，8，1： | 2 |
| 2 | Study of the zinc electroplating process using electrochemical noise technique 显示文摘 | ZHANG Z LENG W H CAI Q Y CAO F H ZHANG J Q | 2005 | Journal of Electroanalytical Chemistry2005，578，： | 1 |
| 3 | Cloning of Beauveria bassiana chitinase gene Bbchitl and its application to improve fungal strain virulence显示文摘 | Fang W G Leng B Xiao Y H | 2005 | Appl Environ Microbiol2005，71，： | 1 |
| 4 | Characteristics of MnO2 catalytic ozonation of sulfosalicylic acid and propionic acid in water显示文摘 | Tong S P Liu W P Leng W H | 2003 | Chemosphere2003，50，： | 1 |
| 5 | Quality control of reconstructed sagittal balance for sagittal imbalance显示文摘 | Chang KW Leng X Zhao W | 2011 | Spine2011，36，3： | 1 |
| 6 | Immunological study of hal domain of he- magglutinin of influenza hSnl virus 显示文摘 | Chiu F F Venkatesan N Wu C R Chou A H Chen H W Lian S P Liu SJ Huang C C Lian W C Chong P Leng C H | 2009 | Biochemical Biophys ResCommun2009，383，1： | 1 |
| 7 | Lp-mixed affine surface area显示文摘 | Wang W D Leng G S | 2007 | J Math Anal Appl2007，54，： | 1 |
| 8 | Study on Marssonina blotch H the re-lationship between eultivars resistant differences and physi- cochemical characters (in Chinese) 显示文摘 | Xie W L Leng H Q | 1990 | J Sichuan Agri Univ1990，8，1： | 1 |
| 9 | Characteristics of MnO2 catalytic ozonation of sulfosalicylic acid and propionic acid in water显示文摘 | Liu W P Leng W H | 2003 | Chemosphere2003，50，： | 1 |
| 10 | Structure-related optical properties of (Pb, La) (Zr, Ti) O3 thin films on indium tin oxide/quartz substrates显示文摘 | LENG W J YANG C R JI H | 2006 | J Appl Phys2006，100，8： | 1 |
| 11 | Electrical and optical properties of lanthanum-modified lead zirconate titanate thin films by radio-frequency magnetron sputtering显示文摘 | LENG W J YANG C R JI H | 2006 | J Appl Phys2006，100，10： | 1 |
| 12 | Enhanced photoc- electrocatalytic performance of Zn-doped WO3 photocata- lysts for nitrite ions degradation under visible light显示文摘 | Cheng X F Leng W H Liu D P | 2007 | Chemosphere2007，68，： | 1 |
| 13 | Outbreak of Serra- tia marcescens postoperative infection traced to barbers and ra- zors 显示文摘 | LENG P HUANG W L HE Y Z | 2015 | Journal of Hospital Infection2015，89，1： | 1 |
| 14 | Chronic angiotensin-(1-7) admin-istration improves vascular remodeling after angioplasty through the regulation of the TGF-beta/Smad signaling pathway in rabbits显示文摘 | Zeng W Chen W Leng X | 2009 | Biachem Biophys Res Commun2009，389，1： | 1 |
| 15 | Glucocorticoid-induced MIF expression by human CEM T cells 显示文摘 | Leng L Wang W Roger T | 2009 | Cytokine2009，48，3： | 1 |
| 16 | En-terocystoplasty or detrusor myectomycomparison ofindications and outcomes for bladder augmentation显示文摘 | LENG W W BLALOCK H J Fredriksson W H | 1999 | J Urol1999，161，： | 1 |
| 17 | Characterization of two newly emerged iso- lates of porcine reproductive and respiratory syndrome virus from Northeast China in 2013显示文摘 | Leng C L Tian Z J Zhang W C Zhang H L Zhai H Y An T Q Peng J M Ye C Sun L Wang Q Sun Y Li L Zhao HY Chang D Cai XH Zhang GH Tong GZ | 2014 | Vet Microbiol2014，171，12： | 1 |
| 18 | Grain characteristicand texture evolution in friction stir welds ofnanostructured oxide dispersion strengthened ferriticsteel 显示文摘 | HAN W T WAN F R LENG B | 2011 | Science and Technology of Welding and Joining2011，16，8： | 1 |
| 19 | Characteristics of MnO2 catalytic ozonation of sulfosalicylic acid and propi-onic acid in water 显示文摘 | Tong S P Liu W P Leng W H | 2003 | Chemosphere2003，50，10： | 1 |
| 20 | Gene-gene and gene-sex epistatic interaction of MiR 146a, IRF5, IKZF1, ETS1 and IL21 in systemic lupus erythematosus显示文摘 | LENG RX WANG W CEN H | 2012 | PloS One2012，7，51： | 1 |
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