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| 1 | Current adjuvant treatment modalities for gastric cancer:From history to the future显示文摘The discrepancy between the surgical technique and the type of adjuvant chemotherapy used in clinical trials and patient outcomes in terms of overall survival rates has led to the generation of different adjuvant treatment protocols in distinct parts of the world.The adjuvant treatment recommendation is generally chemoradiotherapy in the United States,perioperative chemotherapy in the United Kingdom and parts of Europe,and chemotherapy in Asia.These options mainly rely on the United States Intergroup-0116,United Kingdom British Medical Research Council Adjuvant Gastric Infusional Chemotherapy,and the Asian Adjuvant Chemotherapy Trial of S-1 for Gastric Cancer and Capecitabine and Oxaliplatin Adjuvant Study in Stomach Cancer trials.However,the benefits were evident for only certain patients,which were not very homogeneous regarding the type of surgery,chemotherapy regimens,and stage of disease.Whether the dissimilarities in survival are attributable to surgical technique or intrinsic biological differences is a subject of debate.Regardless of the extent of surgery,multimodal therapy may offer modest survival advantage at least for diseases with lymph node involvement.Moreover,in the era of individualized treatment for most of the other cancer types,identification of special subgroups comprising those who will derive more or no benefit from adjuvant therapy merits further investigation.The aim of this review is to reveal the historical evolution and future reflections of adjuvant treatment modalities for resected gastric cancer patients. | Leyla Kilic Cetin Ordu Ibrahim Yildiz Fatma Sen Serkan Keskin Rumeysa Ciftci Kezban Nur Pilanci | 2016 | World Journal of Gastrointestinal Oncology2016，8，5： | 9 |
| 2 | Is obstructive sleep apnea syndrome a risk factor for pulmonary thromboembolism?显示文摘 | Kezban Ozmen Suner AliNihat Annakkaya Umran Toru Talha Dumlu Ege Gulec Balbay Peri Arbak Leyla Yilmaz Aydin Hasan Suner | 2012 | Chinese Medical Journal2012，，20： | 9 |
| 3 | Effect of early preoperative 5-fluorouracil on the integrity of colonic anastomoses in rats显示文摘AIM:To determine the effect of chemotherapy on wound healing by giving early preoperative 5-fluorouracil (5-FU)to rats with colonic anastomoses. METHODS:Sixty Albino-Wistar male rats(median weight,235 g)were used in this study.The rats were fed with standard laboratory food and given tap water ad libitum.The animals were divided into three groups: Group 1:Control group(chemotherapy was not administered),Group 2:Intraperitoneally(IP)administered 5-FU group(chemotherapy was administered IP to animals at a dose of 20 mg/kg daily during the 5 d preceeding surgery),Group 3:Intravenously(IV)administered 5-FU group.Chemotherapy was administered via the penil vein,using the same dosing scheme and duration as the second group.After a 3-d rest to minimize the side effects of chemotherapy,both groups underwent surgery.One centimeter of colon was resected 2 cm proximally from the peritoneal reflection,thensutured intermittently and subsequently end-to-end anastomosed.In each group,half the animals were given anaesthesia on the 3rd postoperative(PO)day and the other half on the 7th PO day,for in vivo analytic procedures.The abdominal incisions in the rats were dissected,all the new and old anastomotic segments were clearly seen and bursting pressures of each anastomotic segment,tissue hydroxyproline levels and DNA content were determined to assess the histologic tissue repair process. RESULTS:When the IV group was compared with the IP group,bursting pressures of the anastomotic segments on the 3rd and 7th PO days,were found to be significantly decreased,hydroxyproline levels at the anastomotic segment on the 7th PO day were significantly decreased(P<0.01). CONCLUSION:In this study,we conclude that early preoperative 5-FU,administered IV,negatively affects wound healing.However,IP administered 5-FU does not negatively affect wound healing. | Leyla Ozel M Sefa Ozel Ahmet Burak Toros Melih Kara Kemal Sirri Ozkan Gurkan Tellioglu Osman Krand Meral Koyuturk Ibrahim Berber | 2009 | World Journal of Gastroenterology2009，15，33： | 7 |
| 4 | Vitamin D,calcium homeostasis and aging显示文摘Osteoporosis is characterized by low bone mass and microarchitecture deterioration of bone tissue, leading to enhanced bone fragility and consequent increase in fracture risk. Evidence is accumulating for an important role of calcium deficiency as the process of aging is associated with disturbed calcium balance. Vitamin D is the principal factor that maintains calcium homeostasis. Increasing evidence indicates that the reason for disturbed calcium balance with age is inadequate vitamin D levels in the elderly. In this article, an overview of our current understanding of vitamin D, its metabolism, and mechanisms involved in vitamin D-mediated maintenance of calcium homeostasis is presented. In addition, mechanisms involved in age-related dysregulation of 1,25(OH)_2D_3action, recommended daily doses of vitamin D and calcium, and the use of vitamin D analogs for the treatment of osteoporosis(which remains controversial) are reviewed. Elucidation of the molecular pathways of vitamin D action and modifications that occur with aging will be an active area of future research that has the potential to reveal new therapeutic strategies to maintain calcium balance. | Vaishali Veldurthy Ran Wei Leyla Oz Puneet Dhawan Yong Heui Jeon Sylvia Christakos | 2016 | Bone Research2016，4，3： | 5 |
| 5 | Laser treatment in 341 patients with exudative agerelated macular degeneration显示文摘AIM:To document the prognosis of laser treatment in patients with exudative age-related macular degeneration(AMD).· METHODS:Efficacy of the intervention was evaluated using a before-after method.· RESULTS:A total of 392 eyes of 341 patients with exudative AMD were examined.77.6% had choroideal neovascularisation(CNV).Before the use of indocyanine green(ICG) angiography,occult CNV was detected in only 1.8% of the eyes,but after the use of ICG angiography,this increased to 19.5%(P<0.001).Of the 349 eyes which were followed up,visual acuity had remained stable in 68.2% of the eyes.There was a statistically significant relationship between localisation of lesion and visual acuity changes on pre-and post-laser treatment(P<0.001).Also there was a statistically significant relationship between localisation of lesion and recurrence(P<0.05).The recurrence was less in subfoveal lesions than that in juxtafoveal and extrafoveal lesions.· CONCLUSION:ICG angiography is highly important in the treatment of occult CNV. | Leyla Atmaca Aysun Idil Pelin Atmaca-Snmez | 2011 | International Journal of Ophthalmology(English edition)2011，4，1： | 5 |
| 6 | 光激酶C基因突变导致的大头精子畸形是阿尔及利亚男性不育症的最常见遗传因素显示文摘克氏综合征和Y染色体微缺失是过去针对男性不育症仅有的两项基因检测分析技术。北非男性经常出现两种罕见的畸形精子症:大头和圆头精子畸形,推荐进行AURKC和DPYl9L2基因检测。对阿尔及利亚男性不育患者进行以上基因检测,评估两种畸形精子症的患病率,并与克氏综合征和Y染色体微缺失的频率进行比较。我们对阿尔及利亚君士坦丁市的IbnRochd医院辅助生殖中心进行不育症咨询的599名患者进行了回顾性研究,其中404人存在精液参数异常现象。14人和7人分别患有典型的大头精子畸形或圆头精子畸形,进而对这些患者进行了AURKC和DPYl9L2基因分析显示,11名大头精子畸形患者存在4URKC基因突变(79%),相当于所有精液异常人群的2.7%。而5名圆头精子畸形患者,相当于1.2%的不育症患者,均存在DPYl9L2基因缺失。通过比较,我们预测该人群中克氏综合症和Y染色体微缺失的患病率分别是1.6%和0.23%。我们的研究表明AURKC基因突变较克氏综合症更常见,它是导致北非男性不育的主要遗传因素。此外,本文也预测了AURKC和DP"觋2基因缺陷发生率分别是Y染色体微缺失发生率的10倍和5倍。 | Leyla Ounis Abdelali Zoghmar Charles Coutton Leila Rouabah Maroua Hachemil Delphine Martinez Guillaume Martinez Ines Bellil Douadi Khelifi Christophe Arnoult Julien Faure Sebti Benbouhedja Abdelkader Rouabah Pierre F Ray | 2015 | Asian Journal of Andrology2015，17，1： | 5 |
| 7 | External Bacterial Flora and Antimicrobial Susceptibility Patterns of Staphylococcus spp. and Pseudomonas spp. Isolated from Two Household Cockroaches, Blattella germanica and Blatta orientalis显示文摘研究被执行估计在 Tebessa (东北阿尔及利亚) 从家庭收集的二只国内蟑螂(Blattella germanica 和 Blatta orientalis ) 的外部细菌的植物群的流行。三个主要的细菌的组是有教养的(全部氧气, enterobacteria,和 staphylococci ) 从蟑螂,和抗菌素的 14 个标本,危险性被测试因为葡萄球菌和 Pseudomonas 孤立。Culturing 证明来自不同家庭的蟑螂的全部的细菌的负担是可比较的(P < 0.001 ) 并且 enterobacteria 是昆虫表面的占优势的殖民者,与细菌的负担(2.1 ㄠ′吗?? | MENASRIA Taha TINE Samir MAHCENE Djaouida BENAMMAR Leyla MEGRI Rochdi BOUKOUCHA Mourad DEBABZA Manel | 2015 | Biomedical and Environmental Sciences2015，28，4： | 4 |
| 8 | Propane catalytic cracking on pretreated La-ZSM-5 zeolite during calcination for light olefins production显示文摘The purpose of this study was to increase light olefins yield and selectivity in catalytic cracking of propane. Pretreatment of ZSM-5 zeolite was performed during calcination. First, lanthanum was loaded on the catalyst by wet impregnation method and then the effect of parameters, such as temperature(400–800 oC), time(120–480 min) and type of stream, on La-ZSM-5 zeolite was examined during calcination using central composite design(CCD) method. Based on the proposed models, the optimized condition for maximizing selectivity of light olefins for air stream was 680 oC and 310 min and for the nitrogen stream was 735 oC and 173 min that under these conditions, selectivity amount increased 24% for nitrogen stream and 19% for air stream as compared with H-ZSM-5 catalyst. The synthesized catalysts were characterized by X-ray diffraction(XRD) and temperature-programmed desorption(TPD) techniques. According to the results of NH_3-TPD, as the temperature increased, the number of strong acid sites(specially Bronsted acid sites) reduced and resulted in increased production of light olefins as well as catalyst stability. Accordingly, stability of the samples calcined with nitrogen stream was higher than the samples calcined with the air stream. | Roya Pouria Leyla Vafi Ramin Karimzadeh | 2017 | Journal of Rare Earths2017，35，6： | 4 |
| 9 | 增强LPG催化裂化催化剂ZSM-5稳定性的新方法:脱铝和负载硅(英文)显示文摘以碳纳米管为模板合成的带有介孔和微孔的ZSM-5分子筛具有不同的复合结构.用三氯乙酸(TCA)可选择性地将中孔的铝脱除.基于TCA分子大小,它可能只扩散到中孔中,因而使得微孔部分不脱铝.从分子筛结构中脱除铝原子导致催化剂中出现中空的空间.若将硅原子填充到空位中,那么介孔部分的结构会变得与硅酸盐类似,不具有催化性能.本文使用含硅的溶液来填充空位,将硅原子直接取代中孔结构中的铝原子.通过此特殊方法改变微孔和介孔的几何形状和性质,从而使改性HZSM-5上的积碳量从14%降低至3%. | Leyla Vafi Ramin Karimzadeh | 2016 | Chinese Journal of Catalysis2016，37，4： | 3 |
| 10 | 糖尿病视网膜病变患者高密度脂蛋白-3和总抗氧化能力以及NO_x水平分析(英文)显示文摘目的:比较糖尿病视网膜病变组与对照组数据,以研究高密度脂蛋白-3(HDL_3)、NO_x和总抗氧化状态之间的关系。方法:前瞻性病例对照研究。106例受试者分为3组,84例2型糖尿病有或无视网膜病变患者,对照组为22例正常人。患者均行血清高密度脂蛋白-3的浓度检测和血清NO_x水平测定。用铁还原法(FRAP)测量血浆总抗氧化能力。结果:糖尿病患者(DM)空腹血糖、糖化血红蛋白、甘油三酯显著高于对照组。正常人中HDL_3水平为14.4(12.0)mg/dL,糖尿病视网膜病变患者为18.1(12.6)mg/dL,糖尿病无视网膜病变患者为14.0(12.5)mg/dL,组间差异无统计学意义(P=0.262)。糖尿病患者FRAP水平低于对照组(P=0.003),但糖尿病视网膜病变组与非糖尿病视网膜病变组之间其差异无统计学意义。结论:研究发现:2型糖尿病视网膜病变患者、糖尿病无视网膜病变患者以及对照组间HDL和HDL_3水平无明显不同。HDL_3可能无法预测糖尿病视网膜病变患者的患病风险。糖尿病患者中血清NO_x水平较高,FRAP水平较低。 | Ustundag Yasemin Akdogan Müberra Demirci Hakan Günay Leyla Huysal Kagan Cevik Sadik Gorkem Barazi Ayse | 2017 | 国际眼科杂志2017，17，12： | 3 |
| 11 | Skin disorders in peritoneal dialysis patients:An underdiagnosed subject显示文摘AIM: To examine all skin changes in peritoneal dialysis(PD) patients followed up in our unit.METHODS: Patients on PD program for at least three months without any known chronic skin disease were included in the study. Patients with already diagnosed skin disease, those who have systemic diseases that may cause skin lesions, patients with malignancies and those who did not give informed consent were excluded from the study. All patients were examined by the same predetermined dermatologist with all findings recorded. The demographic, clinical and laboratory data including measures of dialysis adequacy of patients were recorded also. Statistical Package for Social Sciences(SPSS) for Windows 16.0 standard version was used for statistical analysis.RESULTS: Among the patients followed up in our PD unit, those without exclusion criteria who gave informed consent, 38 patients were included in the study with male/female ratio and mean age of 26/12 and 50.3 ± 13.7 years, respectively. The duration of CKD was 7.86 ± 4.16 years and the mean PD duration was 47.1 ± 29.6 mo. Primary kidney disease was diabetic nephropathy in 11, nephrosclerosis in six, uropathologies in four, chronic glomerulonephritis in three, chronic pyelonephritis in three, autosomal dominant polycystic kidney disease in three patients while cause was unknown in eight patients. All patients except for one patient had at least one skin lesion. Loss of lunula, onychomycosis and tinea pedis are the most frequent skin disorders recorded in the study group. Diabetic patients had tinea pedis more frequently(P = 0.045). No relationship of skin findings was detected with primary renal diseases, comorbidities and medications that the patients were using.CONCLUSION: Skin abnormalities are common in in PD patients. The most frequent skin pathologies are onychomycosis and tinea pedis which must not be overlooked. | Meltem Gursu Sami Uzun Derya Topcuoglu Leyli Kadriye Koc Lamiye Yucel Abdullah Sumnu Egemen Cebeci Oktay Ozkan Ahmet Behlul Leyla Koc Savas Ozturk Rumeyza Kazancioglu | 2016 | World Journal of Nephrology2016，5，4： | 3 |
| 12 | 经瞳孔温热疗法治疗老年黄斑变性所致黄斑中心凹下脉络膜新生血管的长期观察(英文)显示文摘目的:评价经瞳孔温热疗法(TTT)治疗年龄相关性黄斑变性(AMD)所致黄斑中心凹下脉络膜新生血管(CNV)的长期疗效。方法:AMD所致黄斑中心凹下脉络膜新生血管14例14眼。平均年龄67.1岁。记录详尽的眼科检查结果,拍摄彩色眼底相,并行黄斑部光学相干断层成像(OCT)检查。在初诊及随后的复诊中行眼底荧光素血管造影和吲哚青绿血管造影。TTT的治疗参数为:时间1min,光斑大小2 ~3mm,激光能量650 ~800mW。随诊时间5 ~64mo,平均28.6mo。结果:在14眼中,典型性CNV有10眼,典型为主性有2眼,1眼为少量典型性,1型隐匿性CNV有1眼。共4例患者出现治疗后出血,均在短期内吸收。有1眼在治疗后立刻出现了黄斑无灌注区。多数患眼在随诊中可见渗出逐渐减少。在平均28.6mo的随诊中,14只患眼,有5眼视力提高,8眼保持稳定,1眼视力下降。结论:经瞳孔温热疗法在AMD患者中能封闭黄斑中心凹下的CNV,促进网膜下积液的迅速吸收,从而稳定患者的视力。它可以作为一种治疗典型和典型为主性黄斑中心凹下脉络膜新生血管的激光治疗手段。 | Leyla S Atmaca Figen Batioglu | 2008 | 国际眼科杂志2008，8，5： | 3 |
| 13 | Therapeutic alternatives for the treatment of type 1 hepatorenal syndrome: A Delphi technique-based consensus显示文摘AIM To propose several alternatives treatment of type 1 hepatorenal syndrome(HRS-1) what is the most severe expression of circulatory dysfunction on patients with portal hypertension.METHODS A group of eleven gastroenterologists and nephrologists performed a structured analysis of available literature.Each expert was designated to review and answer a question.They generated draft statements for evaluation by all the experts.Additional input was obtained from medical community.In order to reach consensus,a modified three-round Delphi technique method was used.According to United States Preventive Services Task Force criteria,the quality of the evidence and level of recommendation supporting each statement was graded.RESULTS Nine questions were formulated.The available evidence was evaluated considering its quality,number of patients included in the studies and the consistency of its results.The generated questions were answered by the expert panel with a high level of agreement.Thus,a therapeutic algorithm was generated.The role of terlipressin and norepinephrine was confirmed as the pharmacologic treatment of choice.On the other hand the use of the combination of octreotide,midodrine and albumin without vasoconstrictors was discouraged.The role of several other options was also evaluated and the available evidence was explored and discussed.Liver transplantation is considered the definitive treatment for HRS-1.The present consensus is an important effort that intends to organize the available strategies based on the available evidence in the literature,the quality of the evidence and the benefits,adverse effects and availability of the therapeutic tools described.CONCLUSION Based on the available evidence the expert panel was able to discriminate the most appropriate therapeutic alternatives for the treatment of HRS-1. | Juan P Arab Juan C Claro Juan P Arancibia Jorge Contreras Fernando Gomez Cristian Munoz Leyla Nazal Eric Roessler Rodrigo Wolff Marco Arrese Carlos Benítez | 2016 | World Journal of Hepatology2016，8，25： | 3 |
| 14 | 渗出性年龄相关性黄斑变性341例激光治疗效果分析(英文)显示文摘目的:探讨渗出性年龄相关性黄斑变性( AMD) 患者激光治疗的预后。方法:前后比较,以评价治疗的有效性。结果:共纳入341 例392 眼渗出性 AMD 病例,其中77.6%伴有脉络膜新生血管( CNV) 。未使用吲哚氰绿( ICG) 血管造影时,仅在 1. 8% 患眼发现隐匿性 CNV; 而使用 ICG血管造影后,该比例提高到 19. 5% ( P < 0. 001) 。激光治疗后,共 349 眼进入随访,其中 68. 2% 视力保持稳定。经统计学检验,病变部位与治疗前后视力改变相关( P <0. 001) ,也与病变复发相关( P < 0. 05) 。在黄斑中心凹区病变的复发率小于旁中心凹或中心凹外病变。结论:ICG 血管造影对研究隐匿性 CNV 治疗效果相当重要。 | Leyla Atmaca Aysun Idil Pelin Atmaca-Snmez | 2011 | 国际眼科杂志2011，11，7： | 2 |
| 15 | Quantitative Analysis of Faults in Huizhou Sub-basin, Pearl River Mouth Basin显示文摘This study used 2 D seismic profiles to investigate the Cenozoic evolution of faults in the Huizhou Sub-basin. It aims to define the basin structure style through describing the geometric features of the faults and quantitatively analyzing their activities. The results indicate that the boundary faults in the Huizhou Sub-basin display en echelon arrangement in plan view, which indicates that, it was caused by a kind of oblique extension. Calculating the fault slips shows long-term activities of faults occurred in the basin, and some boundary faults kept active after 5.5 Ma. The evolution history of the fault system is reconstructed. Initially, during the Eocene–Early Oligocene, mainly NNE-NE and NW trending faults and NE striking grabens and half-grabens formed in the basin and a series of faults system controlled the deposition. During the Late Oligocene–Early Miocene, the structural activities were relatively weak, the fault activity and the fault growth rate decreased sharply. Finally, in the late stage from Late Miocene to the present, the structure movement was re-activated, and some faults were also reactivated. Our study will help better understand the structural features and evolution of the petroleum-bearing basins in the northern margin of the South China Sea. | Boubacar Hamidou Leyla Junxia Zhang Linlong Yang | 2018 | Journal of Earth Science2018，29，1： | 2 |
| 16 | A simple method for inducing nonalcoholic steatohepatitis with fibrosis显示文摘Background: Nonalcoholic fatty liver disease(NAFLD) is increasingly occurring in sedentary people, and may progress to NASH and hepatocellular carcinoma. It is essential to design affordable animal models for the study of various diseases, including fatty liver, which was the aim of the study. In this study, a high-fat diet was devised that triggers NASH’s animal model quickly and easily. High-fat diet(HFD) was used both with intra-mouth oral gavage and in combination with animal pellets.Methods: Twenty-four male C57 BL/6 J mice were divided into HFD and ND groups, which received a high-fat diet and a normal diet, respectively. At the end of the experiment(fourth week of treatment), body and liver weights, biochemical parameters, PPAR-α gene expression and histopathologic characteristics of the liver were evaluated.Results: During 4 weeks, body weight of mice did not show a significant increase in the HFD group compared to the ND group, while weight gain of the liver was significant. Histological assessment of the HFD group’s liver confirmed NASH symptoms. In the HFD group, HDL-c, SOD, catalase, FRAP, adiponectin, and PPAR-α decreased significantly, and lipid profiles, hepatic enzymes, MDA, leptin, and TNF-α showed a significant increase compared to the ND group.Conclusion: Our high-fat diet has successfully induced all aspects of NASH with fibrosis in 4 weeks, and with low cost. | Leyla Yahaghi Azadeh Ebrahim-Habibi Nasim Hayati-Roodbari Shiva Irani Parichehreh Yaghmaei | 2019 | Animal Models and Experimental Medicine2019，2，4： | 2 |
| 17 | En Echelon Faults and Basin Structure in Huizhou Sag, South China Sea: Implications for the Tectonics of the SE Asia显示文摘The Huizhou sag is situated on the continental shelf of the northern continental margin of the South China Sea. In this paper we present a grid of reflection seismic and well data to characterize the basin structure and prominent unconformities. We employ EBM and 2DMOVE softwares to explore the subsidence history and stratigraphic development history of the basin. We found a rapid subsidence period since 15.5 Ma. Moreover, we calculated the stretching factors of the upper crust and the whole crust in the Huizhou sag. The results show the values are 1.10–1.13 and 1.08–1.31, respectively, indicating faulting in Huizhou sag is relatively small. It is noteworthy that the faults map reveals en echelon distribution at the north and south margins of the basin. We suggest en echelon faults here are caused by the subduction of Proto-South China Sea toward NW Borneo block and cease of the South China Sea. Considering the pronounced unconformities, subsidence rates, fault activities and sediment thickness, the Cenozoic tectonic evolution of the basin can be divided into rifting(49–32 Ma), post-rifted(32–15.5 Ma) and rapid subsidence(15.5–0 Ma) stages. Our study will shed new light on the tectonics of SE Asia and petroleum exploration in the South China Sea. | Boubacar Hamidou Leyla Jianye Ren Jing Zhang Chao Lei | 2015 | Journal of Earth Science2015，26，5： | 2 |
| 18 | Effect of high temperature and cooling conditions on aerated concrete properties显示文摘 | Leyla Tanacan Halit Yasa Ersoy Urnit Arpacioglu | 2009 | Construction Building Mater2009，，23： | 1 |
| 19 | Photoemission study of sulfur and oxygen adsorption显示文摘 | Lukasz Plucinski Leyla Colakerol Sarah Bernardis | 2006 | Surface Science2006，600，： | 1 |
| 20 | Exploring gender effect on adult foreign language learning strategies显示文摘 | Leyla Tereanlioglu | 2004 | Issues in EducationalResearch2004，，14： | 1 |
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