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| 1 | 胡萝卜软腐果胶杆菌巴西亚种(Pectobacterium carotovorum subsp.brasiliense)引起的黄瓜细菌性软腐病在中国发生显示文摘2014—2015年,在中国山东、山西、河北、河南、辽宁等省的黄瓜茎叶上发生了毁灭性的细菌性软腐病,造成了黄瓜产业严重的经济损失。黄瓜叶片、茎、叶柄和果实表面出现流胶;茎基部呈深褐色进而出现湿腐。受侵染的黄瓜叶边缘出现黄斑和湿腐症状,并逐渐扩散至叶片中心。从受侵染组织中分离出45个细菌菌株,在形态学特性鉴定、生理学、生物化学和16Sr RNA基因序列分析的基础上,将病原体鉴定为胡萝卜软腐果胶杆菌(Pectobacterium carotovorum)。多位点序列分析(MLSA)证实,分离菌株是胡萝卜软腐果胶杆菌巴西亚种[Pectobacterium carotovorum subsp.brasiliensis(Pcb)],病原菌归入进化枝II。重新分离获得与原始菌株相同的菌株,证实了分离菌株的致病力。寄主范围测试表明,该菌株具有广泛的寄主范围。目前为止,这是对Pcb引起的黄瓜软腐病——这一对黄瓜生产具有重要经济影响的病害在中国乃至全球范围内的首次报道。 | 冯志琴(译) meng x l chai a l shi y x xie x w ma z h li b j | 2017 | 中国植保导刊2017，37，7： | 10 |
| 2 | Dysfunctional stem and progenitor cells impair fracture healing with age显示文摘Successful fracture healing requires the simultaneous regeneration of both the bone and vasculature;mesenchymal stem cells (MSCs) are directed to replace the bone tissue, while endothelial progenitor cells (EPCs) form the new vasculature that supplies blood to the fracture site. In the elderly, the healing process is slowed, partly due to decreased regenerative function of these stem and progenitor cells. MSCs from older individuals are impaired with regard to cell number, proliferative capacity, ability to migrate, and osteochondrogenic differentiation potential. The proliferation, migration and function of EPCs are also compromised with advanced age. Although the reasons for cellular dysfunction with age are complex and multidimensional, reduced expression of growth factors, accumulation of oxidative damage from reactive oxygen species, and altered signaling of the Sirtuin-1 pathway are contributing factors to aging at the cellular level of both MSCs and EPCs. Because of these geriatric-specific issues, effective treatment for fracture repair may require new therapeutic techniques to restore cellular function. Some suggested directions for potential treatments include cellular therapies, pharmacological agents, treatments targeting age-related molecular mechanisms, and physical therapeutics. Advanced age is the primary risk factor for a fracture, due to the low bone mass and inferior bone quality associated with aging;a better understanding of the dysfunctional behavior of the aging cell will provide a foundation for new treatments to decrease healing time and reduce the development of complications during the extended recovery from fracture healing in the elderly. | Diane R Wagner Sonali Karnik Zachary J Gunderson Jeffery J Nielsen Alanna Fennimore Hunter J Promer Jonathan W Lowery M Terry Loghmani Philip S Low Todd O McKinley Melissa A Kacena Matthias Clauss Jiliang Li | 2019 | World Journal of Stem Cells2019，11，6： | 3 |
| 3 | 抗生素使用的时间长短和使用时的生命阶段与全因/特定原因死亡风险的关系:一项前瞻性队列研究显示文摘过度使用抗生素一直是一个重要的临床问题,抗生素使用与肠道微生物菌群的改变有关,肠道菌群的改变与各种慢性疾病如心血管病和癌症的风险有关。此外,抗生素使用的时间可能是过早死亡的一个危险因素。研究者调查了成年期间使用抗生素的生命阶段和使用持续时间与全因和特定原因死亡风险的关系。该项前瞻性队列研究包括来自护士健康研究、均未患有心血管病或癌症的37516名年龄≥60岁的女性,收集其中年(40~59岁)和老年(≥60岁)使用抗生素的时间(无,<15d,15d至<2个月,或≥2个月)。研究者根据抗生素的使用时间估计10年内全因死亡率和心血管病或癌症的死亡风险比(HR)。在355918人年的随访中,研究者记录了所有原因导致的4536例死亡(包括728例心血管病死亡和1206例癌症死亡) | 刘青(译) 叶鹏(摘 审校) Heianza Y Ma W Li X Cao Y Chan A Rimm EB Hu FB Rexrode K Manson JE Qi L | 2020 | 中华高血压杂志2020，28，2： | 2 |
| 4 | Regulation of apoptosis by type Ⅲ interferons显示文摘 | Li W Lewis-Antes A HuangJ | 2008 | Cell Prolif2008，41，6： | 1 |
| 5 | P16 Gene therapy:a potentially efficacious modality for nasopharyngeal carcinoma显示文摘 | Lee A W Li J H Shi W | 2003 | Mol Cancer Ther2003，2，： | 1 |
| 6 | Molecular beacons for bioanalytical applications 显示文摘 | Tan L Li Y Drake T J Moroz L Wang K Li J Munteanu A Yang C J Martinez K Tan W H | 2005 | Analyst2005，130，7： | 1 |
| 7 | Refinery planning under uncertainty 显示文摘 | Li W K Hui C W Li P Li A X | 2004 | Industrial & Engineering Chemistry Research2004，43，21： | 1 |
| 8 | Selective hepatic vascular exclusion and Pringle maneuver:a comparative study in liver resection显示文摘 | ZHOU W P LI A J PAN Z Y | 2008 | Eur J Surg Oncol2008，34，1： | 1 |
| 9 | Transcriptional repression of the D-type cyclin-dependent kinase inhibitor p16 by the retinoblastoma susceptibility gene product pRb 显示文摘 | Li Yan Nichols M A Shay J W | 1994 | Cancer Res1994，54，23： | 1 |
| 10 | Fractionation of trace elements in some non-agricultural Australian soils显示文摘 | Li J Rate A W Gilkes R J | 2003 | Australian Journal of Soil Research2003，41，： | 1 |
| 11 | Metal-insulator-semiconductor structure on low-temperature grown GaAs 显示文摘 | Chert A Young M Li W | 2006 | Applied Physics Letters2006，89，23： | 1 |
| 12 | Adjusting batch effects in microarray expression data using empirical bayes methods显示文摘 | JOHNSON W E LI C RABINOVIC A | 2007 | Biostatistics2007，8，1： | 1 |
| 13 | DNA hypomethylation induced by drinking wa- ter disinfection by - products in mouse and rat kidney 显示文摘 | Tao L Wang W Li L et a/ | | Toxicol Sci0，87，2： | 1 |
| 14 | Influence of the type of surfactant and hot compaction on the magnetic proper- ties of SrrrCo, nanoflakes显示文摘 | Zheng L Gabay A M Li W | 2011 | Journal of Applied Physics2011，109，07： | 1 |
| 15 | Biliary complications and outcomes of liver transplantation from donors after cardiac death显示文摘 | Maheshwari A Maley W Li Z | 2007 | Liver Transpl2007，13，12： | 1 |
| 16 | Adaptive differential evolution algorithm for multiobjective optimization problems显示文摘 | QIAN W Y LI A J | 2008 | Applied Mathematics and Computation2008，201，12： | 1 |
| 17 | Recent progress and newchallenges in isospin physics with heavy-ion reactions显示文摘 | Li B A Chen L W Ko C M | 2008 | Physics Reports2008，464，： | 1 |
| 18 | High invertase activity in tomato reproductive organs correlates with enhanced sucrose import into, and heat tolerance of, young fruit 显示文摘 | Li Z Palmer W M Martin A P | 2012 | Joumal of Experimental Botany2012，63，3： | 1 |
| 19 | Earthworm avoidance of biochar can be mitigated by wetting 显示文摘 | Li D Hockaday W C Masiello C A | 2011 | Soil Biol Biochem2011，43，8： | 1 |
| 20 | Knockdown of RLIP76 expression by RNA interference inhibits proliferation, enhances apoptosis, and increases chemosensitivity to daunorubicin in U937 leukemia cells显示文摘 | Yao K Xing H Yang W Liao A Wu B Li Y | 2014 | Tumour Biol2014，35，： | 1 |
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