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| 1 | Ellagic acid induces apoptosis through inhibition of nuclear factor κB in pancreatic cancer cells显示文摘AIM:To determine the effect of ellagic acid on apop-tosis and proliferation in pancreatic cancer cells and to determine the mechanism of the pro-survival effects of ellagic acid. METHODS:The effect of ellagic acid on apoptosis was assessed by measuring Phosphatidylserine externalization,caspase activity,mitochondrial membrane potential and DNA fragmentation;and proliferation by measuring DNA thymidine incorporation. Mitochondrial membrane potential was measured in permeabilized cells,and in isolated mitochondria. Nuclear factor kB(NF-kB) activity was measured by electromobility shift assay(EMSA) . RESULTS:We show that ellagic acid,a polyphenolic compound in fruits and berries,at concentrations 10 to 50 mmol/L stimulates apoptosis in human pancreatic adenocarcinoma cells. Further,ellagic acid decreases proliferation by up to 20-fold at 50 mmol/L. Ellagic acid stimulates the mitochondrial pathway of apoptosis associated with mitochondrial depolarization,cytochrome C release,and the downstream caspaseactivation. Ellagic acid does not directly affect mitochondria. Ellagic acid dose-dependently decreased NF-kB binding activity. Furthermore,inhibition of NF-kB activity using IkB wild type plasmid prevented the effect of ellagic acid on apoptosis. CONCLUSION:Our data indicate that ellagic acid stimulates apoptosis through inhibition of the prosu-rvival transcription factor NF-kB. | Mouad Edderkaoui Irina Odinokova Izumi Ohno Ilya Gukovsky Vay Liang W Go Stephen J Pandol Anna S Gukovskaya | 2008 | World Journal of Gastroenterology2008，14，23： | 30 |
| 2 | Introduction and constitutive expression of rice chitinase gene in bread wheat using biolistic bombardment and the bar gene as a selectable maker显示文摘 | Chen W P Gu X Liang G H Muthukrishnan S Chen P D Liu D J Giu B S | 1998 | Theor Appl Genet1998，97，12： | 2 |
| 3 | Role and relevance of polarity and hindrance of vinyl monomers in graft copolymerization onto potato starch显示文摘 | Fu Z S Liang W D Yang A M | 2002 | J Appl Polym Sci2002，85，4： | 2 |
| 4 | Epitaxial interface of nanocrystalline TiC foraned between Cu-10Sn-15Ti alloy and diamond显示文摘 | LI W C LIANG C LIN S T | 2002 | Diamond and Related Materials2002，，11： | 1 |
| 5 | Epidemiological serosurvey of hep-atitis 6 in China-declining HBV prevalence due to hepatitis Bvaccination 显示文摘 | Liang X Bi S Yang W | 2009 | Vaccine2009，27，47： | 1 |
| 6 | Rare Metal Materials and Engineering显示文摘 | Chen K H Liang W Wang S P | 2010 | 39(2):3522010，39，2： | 1 |
| 7 | Epidemiological serosurvey of hepa-titis B in China--declining HBV prevalence due to hepatitis B vaccination显示文摘 | Liang X Bi S Yang W | | 0，，47： | 1 |
| 8 | Human infections with the emerging avian influenza A H7N9 virus from wet market poultry:clinical analysis and characterisation of viral genome显示文摘 | Chen Y Liang W Yang S | | 0，，： | 1 |
| 9 | Modeling ammonium adsorption on broiler litter and Cake显示文摘 | Liang W Z Sanjay B S John J C | 2013 | Water Air Soil Pollut2013，224，2： | 1 |
| 10 | X-ray and NMR structure of human Bcl-XL, an in- hibitor of programmed cell death 显示文摘 | MUCHMORE S W SATTLER M LIANG H | 1996 | Nature1996，381，6580： | 1 |
| 11 | Interfacial segregation of Ti in the brazing of diamond grits onto a steel substrate using a Cu-Sn-Ti brazing alloy 显示文摘 | LI W C LIANG C LIN S T | 2002 | Metallurgical and Materials Transaction A2002，33，： | 1 |
| 12 | Roles of substrate microorganism and urease activities Ⅰ: wastewater purification in a constructed wetland system 显示文摘 | Liang W Wu Z B Cheng S P | 2003 | Ecological Engineer2003，21，： | 1 |
| 13 | Convolution Analysis of Milling Force Pulsation显示文摘 | Wang J J Liang S Y Book W J | 1994 | ASME Journal of Engineering Industries1994，116，： | 1 |
| 14 | Roles of substrate microorganisms and urease activities in wastewater purification in a constructed wetland system显示文摘 | Liang W Wu Z B Cheng S P | 2003 | Ecological Engineering2003，21，23： | 1 |
| 15 | Fixation, not death,reduces sensitivity of DTI in detecting optic nerve damage显示文摘 | Sun S W Liang H F Xie M Oyoyo U Lee A | 2009 | Neuroimage2009，44，： | 1 |
| 16 | Frequency domain equalization and interference cancellation for TD-SCDMA downlink in fast time-varying environments显示文摘 | Wang Y Liang Y and Leon W S | 2008 | IEEE Transactions on Vehicular Technology2008，57，1： | 1 |
| 17 | Molecular sieve membrane: supported metal-organic framework with high hydrogen selectivity 显示文摘 | Li Y S Liang F Y Bux H Feldhoff A Yang W S Caro J | 2010 | Angezvandte Chemie International Edition2010，49，3： | 1 |
| 18 | Europ Polym J显示文摘 | Xu W B Liang G D Zhai H B Tang S P Hang G P Pan W P | 2003 | 39:1 4672003，39，： | 1 |
| 19 | Inhibition of Dl14 signaling inhibits tumour growth by deregulating angiogenesis 显示文摘 | Ridgway J Zhang G Wu Y Stawicki S Liang W C Chanthery Y | 2006 | Na- ture2006，444，： | 1 |
| 20 | Structure of severe fever with thrombocytopenia syndrome virus nucleocapsid protein in complex with suramin reveals therapeutic potential显示文摘 | Jiao L Y Ouyang S Y Liang M F Niu F F Shaw N Wu W Ding W Jin C Peng Y Zhu Y P Zhang F S Wang T Li C Zuo X B Luan C H Li D X Liu Z J | 2013 | J Virol2013，87，12： | 1 |
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