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| 1 | Escherichia coli in chronic inflammatory bowel diseases: An update on adherent invasive Escherichia coli pathogenicity显示文摘Escherichia coli(E. coli), and particularly the adherent invasive E. coli(AIEC) pathotype, has been increasingly implicated in the ethiopathogenesis of Crohn's disease(CD). E. coli strains with similar pathogenic features to AIEC have been associated with other intestinal disorders such as ulcerative colitis, colorectal cancer, and coeliac disease, but AIEC prevalence in these diseases remains largely unexplored. Since AIEC was described one decade ago, substantial progress has been made in deciphering its mechanisms of pathogenicity. However, the molecular bases that characterize the phenotypic properties of this pathotype are still not well resolved. A review of studies focused on E. coli populations in inflammatory bowel disease(IBD) is presented here and we discuss about the putative role of this species on each IBD subtype. Given the relevance of AIEC in CD pathogenesis, we present the latest research findings concerning AIEC host-microbe interactions and pathogenicity. We also review the existing data regarding the prevalence and abundance of AIEC in CD and its association with other intestinal diseases from humans and animals, in order to discuss the AIEC disease- and hostspecificity. Finally, we highlight the fact that dietarycomponents frequently found in industrialized countries may enhance AIEC colonization in the gut, which merits further investigation and the implementation of preventative measures. | Margarita Martinez-Medina Librado Jesus Garcia-Gil | 2014 | World Journal of Gastrointestinal Pathophysiology2014，5，3： | 19 |
| 2 | Impact of PRRSV on activation and viability of antigen presenting cells显示文摘Porcine reproductive and respiratory syndrome(PRRS) is one of the most important diseases of swine industry. The causal agent, PRRS-virus(PRRSV), is able to evade the host immune response and survive in the organism causing transient infections. Despite all scientific efforts, there are still some gaps in the knowledge of the pathogenesis of this disease. Antigen presenting cells(APCs), as initiators of the immune response, are located in the first line of defense against microorganisms, and are responsible for antigen recognition, processing and presentation. Dendritic cells(DCs) are the main type of APC involved in antigen presentation and they are susceptible to PRRSV infection. Thus, PRRSV replication in DCs may trigger off different mechanisms to impair the onset of a host effective immune response against the virus. On the one side, PRRSV may impair the basic functions of DCs by regulating the expression of major histocompatibility complex class Ⅱ and CD80/86. Other strategy followed by the virus is the induction of cell death of APCs by apoptosis, necrosis or both of them. The impairment and/or cell death ofAPCs could lead to a failure in the onset of an efficient immune response, as long as cells could not properly activate T cells. Future aspects to take into account are also discussed in this review. | Irene M Rodríguez-Gómez Jaime Gómez-Laguna Librado Carrasco | 2013 | World Journal of Virology2013，2，4： | 4 |
| 3 | v5:a software for comprehensive analysis of DNA polymorphism data显示文摘 | Librado P Rozas J Dna S P | 2009 | Bioinformatics2009，25，： | 1 |
| 4 | DnaSP v5: A software for eomprehensive analysis of DNA polymorphism data显示文摘 | Librado P Rozas J | 2009 | Bioinformatics2009，25，11： | 1 |
| 5 | Dna S P v5: A software for comprehensive analysis of DNA polymorphism data 显示文摘 | Librado P Rozas J | 2009 | Bioinformatics2009，25，11： | 1 |
| 6 | DnaSP v5 : A software for comprehensive anal- ysis of DNA polymorphism data 显示文摘 | Librado P Rozas J | 2009 | Bioinformatics2009，25，： | 1 |
| 7 | DnaSP vS: a software for comprehensive analysis of DNA polymorphism data 显示文摘 | Librado P Rozas J | 2009 | Bioinformaties2009，25，11： | 1 |
| 8 | DnaSP v5:a software for comprehensive analyBis of DNA polymorphism data显示文摘 | Librado P Rozas J | 2009 | Bioinformatics2009，25，11： | 1 |
| 9 | DNA SP v5:a software for comprehensive analysis of DNA polymorphism data显示文摘 | Librado P Rozas J | 2009 | Bioinformatics2009，25，11： | 1 |
| 10 | DnaSP vS: a software for com- prehensive analysis of DNA polymorphism data 显示文摘 | Librado P Rozas J | 2009 | Bioinformatics2009，25，11： | 1 |
| 11 | DnaSP v5: A software for com- prehensive analysis of DNA polymorphism data显示文摘 | Librado P Rozas J | 2009 | Bioinformatics2009，，25： | 1 |
| 12 | A software for comprehensive analysis of DNA polymorphism data 显示文摘 | Librado P Rozas J | 2009 | Bioinformaties2009，25，11： | 1 |
| 13 | DNASP v5:a software for comprehensive analysis of DNA Polymorphism data显示文摘 | LIBRADO P ROZAS J | 2009 | Bioinformatics2009，，25： | 1 |
| 14 | DnaSP v5 ; A software for comprehensive anal-ysis of DNA polymorphism data 显示文摘 | Librado P Rozas J | 2009 | Bioinformatics2009，25，11： | 1 |
| 15 | DnaSP v5: a software for comprehensive analysis of DNA polymorphism data 显示文摘 | Librado P Rozas J | 2009 | Bioinformatics2009，25，11： | 1 |
| 16 | DnaSP v5: a software for comprehensive analysis of DNA polymorphism data显示文摘 | Librado P Rozas J | 2009 | Bioinformatics2009，25，11： | 1 |
| 17 | DnaSP v5 : A software for comprehensive anal- ysis of DNA polymorphism data 显示文摘 | Librado P Rozas J | 2009 | Bioinformatics2009，25，： | 1 |
| 18 | DnaSP v5: a software for comprehensive analysis of DNA polymorphism data显示文摘 | Librado P Rozas J | 2009 | Bioinformatics2009，25，： | 1 |
| 19 | DnaSP v5:a software for comprehensive analysis of DNA polymorphism data显示文摘 | Librado P Rozas J | 2009 | Bioinformatics2009，25，11： | 1 |
| 20 | Antimicrobial and an- tioxidant activities of unripe papaya显示文摘 | JAMES A O LIBRADO A S GEMMA M R | 1993 | Life Sci1993，17，： | 1 |
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