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| 1 | Chinese Multidisciplinary Expert Consensus on the Diagnosis and Treatment of Hyperuricemia and Related Diseases显示文摘 | Zou, He-Jian Wu, Hu-Sheng Zhou, Jing-Guo Zeng, Xue-Jun Dai, Lie Wu, Hua-Xiang Zhu, Xiao-Xia Mei, Chang-Lin Hao, Chuan-Ming Chen, Nan Liu, Bi-Cheng Chen, Jiang-Hua Yang, Li Nie, Jing Yu, Chen Peng, Ai Yu, Sheng-Qiang Li, Lin Ge, Jun-Bo Huo, Yong Zhang, Shu-Yang Chen, Yun-Dai Dong, Yu-Gang Liang, Chun Dai, Yu-Xiang Gao, Xin Li, Chang-Gui Zhao, Jia-Jun Chen, Hai-Bing Cheng, Zhi-Feng Lin, Huan-Dong Guan, Yang-Tai Wang, Kai Luo, Ben-Yan Dai, Ruo-Lian Jiang, Quan Xue, Luan Liang, Chao-Chao Chen, Ming Fan, Song | 2017 | Chinese Medical Journal2017，，20： | 30 |
| 2 | Jianpi Qingchang decoction alleviates ulcerative colitis by inhibiting nuclear factor-κB activation显示文摘AIM To inve s t igat e t he t he r ape ut ic e f f e c t of Jianpi Qingchang decoction(JPQCD) on dextran sulfate sodium(DSS)-induced ulcerative colitis(UC) in mice.METHODS C57BL/c mice were injected intragastrically with 5% DSS instead of drinking water for 7 d, and their body weight, diarrhea severity and fecal bleeding were monitored, while the mice in the control group were treated with standard drinking water, without DSS. After 7 d, the DSS drinking water was changed to normal water and the DSS group continued with DSS water. The control and DSS groups were given normal saline by intragastric injection. The 5-aminosalicylic acid(5-ASA) group was treated orally with 5-ASA at a dose of 100 mg/kg daily. The JPQCD group was treated orally with JPQCD at a dose of 17.1 g/kg daily. On day 14, the colon length was measured, the colorectalhistopathological damage score was assessed, and protein levels of interleukin(IL)-1β, IL-8 and tumor necrosis factor-alpha(TNF-α) in colon supernatants were measured by enzyme-linked immunosorbent assay. m RNA expression of IL-1β, IL-8, TNF-α and nuclear factor-kappa B(NF-κB) was detected by realtime quantitative polymerase chain reaction. Western blotting was used to detect the protein expression of NF-κB and inhibitor of kappa B. RESULTS Acute inflammation occurred in the mice administered DSS, including the symptoms of losing body weight, loose feces/watery diarrhea and presence of fecal blood; all these symptoms worsened at 7 d. The colons of mice treated with DSS were assessed by histological examination, and the results confirmed that acute inflammation had occurred, as evidenced by loss of colonic mucosa and chronic inflammatory cell infiltration, and these features extended into the deeper layer of the colon walls. The expression levels of IL-1β, IL-8 and TNF-α in the DSS group were higher than those in the control group(P < 0.05), and the expression levels of IL-1β, IL-8 and TNF-α in the JPQCD and 5-ASA groups were lower than those in the DSS group after treating with JPQCD and 5-ASA. Comparing with the DSS group, the mR NA level of IL-1β, IL-8, TNF-α and NF-κB was significantly reduced by 5-ASA and JPQCD. The difference between JPQCD and 5-ASA groups was not statistically significant(P > 0.05). Comparing with the DSS group, due to using JPQCD and 5-ASA, significant suppression of activation in DSSinduced NF-κB and increased phosphorylation of IκB in mice with experimental colitis occurred(P < 0.05). The difference between the JPQCD group and the 5-ASA group was not statistically significant(P > 0.05). CONCLUSION Activation of the NF-κB signaling pathway is inhibited by JPQCD, which shows the potential mechanism by which JPQCD treats UC. | Lie Zheng Ya-Li Zhang Yan-Cheng Dai Xuan Chen De-Liang Chen Yue-Ting Dai Zhi-Peng Tang | 2017 | World Journal of Gastroenterology2017，23，7： | 30 |
| 3 | Jianpi Qingchang decoction regulates intestinal motility of dextran sulfate sodium-induced colitis through reducing autophagy of interstitial cells of Cajal显示文摘AIM To investigate the underlying effect of Jianpi Qingchang decoction(JQD) regulating intestinal motility of dextran sulfate sodium(DSS)-induced colitis in mice. METHODS C57BL/6 mice were randomly divided into four groups: the control group, the DSS group, the JQD group, and the 5-aminosalicylic acid group. Except for the control group, colitis was induced in other groups by giving distilled water containing 5% DSS. Seven days after modeling, the mice were administered corresponding drugs intragastrically. The mice were sacrificed on the 15^(th) day. The disease activity index, macroscopic and histopathologic lesions, and ultrastructure of colon interstitial cells of Cajal(ICC) were observed. The levels of tumor necrosis factor-alpha(TNF-α), interleukin(IL)-1β, IL-10 and interferon gamma(IFN-γ), the expression of nuclear factor-kappa B(NF-κB) p65, c-kit, microtubule-associated protein 1 light chain 3(LC3-Ⅱ) and Beclin-l m RNA, and the colonic smooth muscle tension were assessed. RESULTS Acute inflammation occurred in the mice administered DSS. Compared with the control group, the levels of IL-1β, TNF-α, IL-10 and IFN-γ, the expression of LC3-Ⅱ, Beclin-1 and NF-κB p65 m RNA, and the contractile frequency increased(P < 0.05), the expression of c-kit m RNA and the colonic smooth muscle contractile amplitude decreased in the DSS group(P < 0.05). Compared with the DSS group, the levels of IL-10 and IFN-γ, the expression of c-kit m RNA, and the colonic smooth muscle contractile amplitude increased(P < 0.05), the levels of TNF-α and IL-1β, the expression of LC3-Ⅱ, Beclin-1 and NF-κB p65 m RNA, and the contractile frequency decreased in the JQD group(P < 0.05).CONCLUSION JQD can regulate the intestinal motility of DSS-induced colitis in mice through suppressing intestinal inflammatory cascade reaction, reducing autophagy of ICC, and regulating the network path of ICC/smooth muscle cells. | Yan-Cheng Dai Lie Zheng Ya-Li Zhang Xuan Chen De-Liang Chen Li-Juan Wang Zhi-Peng Tang | 2017 | World Journal of Gastroenterology2017，23，26： | 26 |
| 4 | Gut microbiota contributes to the distinction between two traditional Chinese medicine syndromes of ulcerative colitis显示文摘BACKGROUND Ulcerative colitis(UC)is considered to be closely associated with alteration of intestinal microorganisms.According to the traditional Chinese medicine(TCM)theory,UC can be divided into two disease syndromes called Pi-Xu-Shi-Yun(PXSY)and Da-Chang-Shi-Re(DCSR).The relationships among gut microbiota,TCM syndromes,and UC pathogenesis have not been well investigated.AIM To investigate the role of gut microbiota in UC and the distinction of microbiota dysbiosis between PXSY and DCSR syndromes.METHODS From May 2015 to February 2016,UC patients presenting to LongHua Hospital who met the established inclusion and exclusion criteria were enrolled in this retrospective study.Fresh stool specimens of UC patients with PXSY or DCSR were collected.The feces of the control group came from the health examination population of Longhua Hospital.The composition of gut bacterial communities in stool samples was determined by the pyrosequencing of 16S ribosomal RNA.The high-throughput sequencing reads were processed with QIIME,and biological functions were predicted using Phylogenetic Investigation of Communities by Reconstruction of Unobserved States.RESULTS The composition of gut bacterial communities in 93 stool samples(30 healthy controls,32 patients with PXSY syndrome,and 31 patients with DCSR syndrome)was determined by the pyrosequencing of 16S ribosomal RNA.Beta diversity showed that the composition of the microbiota was different among the three groups.At the family level,Porphyromonadaceae,Rikeneliaceae,and Lachnospiraceae significantly decreased while Enterococcus,Streptococcus,and other potential pathogens significantly increased in UC patients compared to healthy subjects.At the genus level,Parabacteroides,Dorea,and Ruminococcus decreased while Faeca-libacterium showed increased abundance in UC compared to healthy controls.Five differential taxa were identified between PXSY and DCSR syndromes.At the genus level,a significantly increased abundance of Streptococcus was observed in DCSR patients,while Lachnoclostridium increased in PXSY patients.The differential functional pathways of the gut microbiome between the PXSY and DCSR groups mainly included lipid metabolism,immunity,and the metabolism of polypeptides.CONCLUSION Our study suggests that the gut microbiota contributes to the distinction between the two TCM syndromes of UC. | Ya-Li Zhang Li-Ting Cai Jun-Yi Qi Yun-Zheng Lin Yan-Cheng Dai Na Jiao You-Lan Chen Lie Zheng Bei-Bei Wang Li-Xin Zhu Zhi-Peng Tang Rui-Xin Zhu | 2019 | World Journal of Gastroenterology2019，25，25： | 19 |
| 5 | Mechanism of Jianpi Qingchang Huashi Recipe in treating ulcerative colitis:A study based on network pharmacology and molecular docking显示文摘BACKGROUND Ulcerative colitis(UC)is a refractory intestinal disease with alternating onset and remission and a long disease course,which seriously affects the health and quality of life of patients.The goal of treatment is to control clinical symptoms,induce and maintain remission,promote mucosal healing,and reduce recurrence.Clinical trials have shown unsatisfactory clinical response rates.As a supplementary alternative medicine,traditional Chinese medicine has a rich history and has shown good results in the treatment of UC.Because of the quality of herbal medicine and other factors,the curative effect of traditional Chinese medicine is not stable enough.The mechanism underlying the effect of Jianpi Qingchang Huashi Recipe(JPQCHSR)on inducing UC mucosal healing is not clear.AIM To investigate the potential mechanism of JPQCHSR for the treatment of UC based on network pharmacology and molecular docking.METHODS Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform was used to extract the active components and action targets of JPQCHSR,and the target names were standardized and corrected through UniProt database.The related targets of UC were obtained through GeneCards database,and the intersection targets of drugs and diseases were screened by jvenn online analysis tool.The visual regulatory network of'Traditional Chinese medicine-active components-target-disease'was constructed using Cytoscape software,the protein interaction network was constructed using STRING database,and enrichment analysis of gene ontology and Kyoto Encyclopedia of Genes and Genomes pathways was conducted through R software.At last,the active components were docked with the core target through SYBYL-X 2.1.1 software.RESULTS Through database analysis,a total of 181 active components,302 targets and 205 therapeutic targets were obtained for JPQCHSR.The key compounds include quercetin,luteolin,kaempferol,etc.The core targets involved STAT3,AKT1,TP53,MAPK1,MAPK3,JUN,TNF,etc.A total of 2861 items were obtained by GO enrichment analysis,and 171 items were obtained by KEGG(Kyoto Encyclopedia of Genes and Genomes)pathway enrichment analysis.The results of molecular docking showed that the key active components in JPQCHSR had certain affinity with the core target.CONCLUSION The treatment of UC with JPQCHSR is a complex process of multi-component,multi-target and multi-pathway regulation.The mechanism of this Recipe in the treatment of UC can be predicted through network pharmacology and molecular docking,so as to provide theoretical reference for it to better play its therapeutic role. | Lie Zheng Xin-Li Wen Yan-Cheng Dai | 2021 | World Journal of Clinical Cases2021，9，26： | 4 |
| 6 | Reconstruction of segmental bone defects in the rabbit ulna using periosteum encapsulated mesenchymal stem cells-loaded poly(lactic-co-glycolic acid) scaffolds显示文摘 | ZHANG Xin QI Yi-ying ZHAO Teng-fei LI Dan DAI Xue-song NIU Lie HE Rong-xin | 2012 | Chinese Medical Journal2012，，22： | 4 |
| 7 | 0.35%THz pulse conversion efficiency achieved by Ti:sapphire femtosecond laser filamentation in argon at 1 kHz repetition rate显示文摘In this study,an optical setup for generating terahertz(THz)pulses through a two-color femtosecond laser filament was carefully designed to achieve a precise overlap of two-color laser pulses in space and time.β-barium borate(BBO),α-BBO,and a dual-wavelength plate were used to compensate the phase delay of the two-color lasers.Tilting ofα-BBO could further realize the precise spatial overlap of the two beams by counteracting the walk-off effect.The maximum out-put THz pulse energy reached 21μJ in argon gas when using a commercial Ti:sapphire laser with a pulse energy of 6 mJ at a 1 kHz repetition rate.The corresponding conversion efficiency exceeded 0.35%. | Zhiqiang Yu Nan Zhang Jianxin Wang Zijie Dai Cheng Gong Lie Lin Lanjun Guo Weiwei Liu | 2022 | Opto-Electronic Advances2022，5，9： | 2 |
| 8 | Antigen-binding characteristics of AbCD71 and its inhibitory effect on PHA-induced lymphoproliferation显示文摘瞄准:调查准备 recombinant 的 anti-lymphoproliferative 效果 71 单音的同种细胞的抗体(AbCD71 ) 它是创作了的区别(CD ) 的妄想的人 / 鼠科的反簇导出老鼠,抗原绑定变量区域和导出人的经常的区域。方法:在原生质标志建设和 transfection 以后,在 transfectoma 上层清液的 AbCD71 的表示被三明治 ELISA 决定。间接免疫荧光试金被用来测量抗原绑定特征和百分比表示 CD71 的外部血单音的原子房间(PBMC ) 。抗体经由 diethylaminoethyl (DEAE ) 从腹水被净化 -Sephadex A-50 层析然后由 SDS 页识别了。最后,导致公众房产管理局的 PBMC 增长上的 AbCD71 的禁止的效果被甲基 thiazolyl tetrazolium (MTT ) 计算试金。结果:重链(C (H)) 和 AbCD71 的轻链(C (L)) 的经常的领域分别地在人的 Cgamma 家庭和人的 Ckappa 家庭。AbCD71 能与它的原来的鼠科的 mAb 竞争与 CD71 积极的人的白血病房间线 CEM 房间绑。AbCD71 能禁止单音的原子房间增长由 phytohemagglutinin (公众房产管理局) 导致了的外部血以一种剂量依赖者方式的在试管内,特别在时间点 0 和 12 h 在以后感应。没有统计差别什么时候与原来的鼠科的 mAb 相比。结论:AbCD71 是有希望的抑制免疫力的药。我们与妄想的人 / 鼠科的 mAb 堵住 CD71 的途径为延长紧密相联的接枝幸存提供新奇策略。 | Ping LEI Yong HE Qing YE Hui-fen ZHU Xiao-mei YUAN Jing LIE Wei XING Sha WO Wei DAI Xin SHEN Guo-bin WANG Guan-xin SHEN | 2007 | Acta Pharmacologica Sinica2007，28，10： | 2 |
| 9 | Moment Resistance of Steel Ⅰ-Beam to CFT Column Connection显示文摘 | Chiew S P Lie S T Dai C W | 2001 | Journal of Structural Engineering2001，，： | 1 |
| 10 | Dexmedetomidine reduces the incidence of fentanyl-induced cough: Aou- ble-blind,randomized,and placebo-controlled study 显示文摘 | LIANG liE JUNMEI XU RUPING DAI | 2012 | Upsala Journal of Medical Sciences2012，117，： | 1 |
| 11 | Moment Resistance of Steel I- beam to CFT Column Connections 显示文摘 | Chiew S P Lie S T Dai C W | 2001 | Journal of Structural Engineering2001，127，10： | 1 |
| 12 | Moment resistance ofsteel I-beam to CFT column connections显示文摘 | Chiew S P Lie S T Dai Chao-Wei | 2001 | Journal ofStructural Engineering2001，127，10： | 1 |
| 13 | Moment Resistance of Steel I- Beam to CFT Column Connections显示文摘 | Chiew S P Lie S T Dai C W | 2005 | Journal of Structural Engineering2005，127，10： | 1 |
| 14 | Moment resistance of steel Ⅰ-beam to CFT column connections显示文摘 | CHIEW S P LIE S T DAI C W | 2001 | Journal of Structural Engineering2001，127，10： | 1 |
| 15 | Highly Stable CdSe/CdS/ZnS Fluorophores in Acidic Environment:Acile Preparation and Modification of Core/shell/shell Nanocrystals显示文摘We described a facile method for preparing CdSe/CdS/ZnS core/shell/shell nanocrystals from air-stable single source precursors.The single source precursors of cadmium ethylxanthate and zinc ethylxanthate were used to form CdS and ZnS shell layers in octadecene.An efficient modification of CdSe/CdS/ZnS nanocrystals was subsequently performed to obtain hydrophilic nanocrystal fluorophores with good stability in a pH range of 1.6-10. | YUE Yang GE Mei-ying LIU Yan WU Jie CHEN Ping LIN Lie LIU Yu-feng SUN Yan CHEN Xin DAI Ning | 2010 | Chemical Research in Chinese Universities2010，26，6： | 1 |
| 16 | Moment resistance of steel I-beam to CFT column connections 显示文摘 | CHICW S P LIE S T DAI C W | 2001 | Journal of Structural Engineering2001，127，10： | 1 |
| 17 | Moment resistance of steel Ibeam to CFT column connections显示文摘 | Chiew S P Lie S T Dai C W | 2001 | Journal of Structural Engineering-ASCE2001，127，10： | 1 |
| 18 | Jianpi Qingchang Bushen decoction improves inflammatory response and metabolic bone disorder in inflammatory bowel disease-induced bone loss显示文摘BACKGROUND Bone loss and osteoporosis are commonly described as extra-intestinal manifestations of inflammatory bowel disease(IBD).Jianpi Qingchang Bushen decoction(JQBD)is a prescription used in clinical practice.However,further studies are needed to determine whether JQBD regulates the receptor activator of nuclear factor kappa B(NF-κB)(RANK)/receptor activator of NF-κB ligand(RANKL)/osteoprotegerin(OPG)pathways and could play a role in treating IBD-induced bone loss.AIM To evaluate the therapeutic effect of JQBD in IBD-induced bone loss and explore the underlying mechanisms.METHODS An IBD-induced bone loss model was constructed by feeding 126-to-8-wk-old interleukin-10(IL-10)-knockout mice with piroxicam for 10 d.The mice were randomly divided into model and JQBD groups.We used wild-type mice as a control.The JQBD group was administered the JQBD suspension for 2 wk by gavage,while the control and model groups were given normal saline at the corresponding time points.All mice were killed after the intervention.The effect of JQBD on body weight,disease activity index(DAI),and colon length was analyzed.Histopathological examination,colon ultrastructure observation,and micro-computed tomographic scanning of the lumbar vertebrae were performed.The gene expression of NF-κB,tumor necrosis factor-α(TNF-α),IL-1β,IL-6,and IL-8 in the colon was evaluated by real-time polymerase chain reaction.Colon samples were assessed by Western blot for the expression of RANKL,OPG,RANK,and NF-κB proteins.RESULTS The model group lost body weight,had a shorter colon,and showed a dramatic increase in DAI score,whereas JQBD had protective and therapeutic effects.Treatment with JQBD significantly improved inflammatory cell infiltration and reduced crypt abscess and ulcer formation.Threedimensional imaging of the vertebral centrum in the model group revealed a lower bone mass,loose trabeculae,and“rod-shaped”changes in the structure compared to the control group and JQBD groups.The bone volume/total volume ratio and bone mineral density were significantly lower in the model group than in the control group.JQBD intervention downregulated the NF-κB,TNF-α,IL-1β,IL-6,and IL-8 m RNA expression levels.The RANKL and OPG protein levels were also improved.CONCLUSION JQBD reduces inflammation of the colonic mucosa and inhibits activation of the RANK/RANKL/OPG signaling pathway,thereby reducing osteoclast activation and bone resorption and improving bone metabolism. | Ya-Li Zhang Qian Chen Lie Zheng Zi-Wei Zhang Yu-Jun Chen Yan-Cheng Dai Zhi-Peng Tang | 2022 | World Journal of Gastroenterology2022，28，13： | 1 |
| 19 | In situ delivery of apoptotic bodies derived from mesenchymal stem cells via a hyaluronic acid hydrogel:A therapy for intrauterine adhesions显示文摘Stem cell-based and stem cell-derived exosome-based therapies have shown promising potential for endometrial regeneration and the clinical treatment of intrauterine adhesions(IUAs).Evidence shows that apoptosis occurs in a majority of grafted stem cells,and apoptotic bodies(ABs)play a critical role in compensatory tissue regeneration.However,the therapeutic potential of AB-based therapy and its mechanism have not been explored in detail.Here,a cell-free therapeutic strategy was developed by incorporating mesenchymal stem cell-derived ABs into a hyaluronic acid(HA)hydrogel to achieve endometrial regeneration and fertility restoration.Specifically,we found that the ABs could induce macrophage immunomodulation,cell proliferation,and angiogenesis in vitro.The HA hydrogel promoted the retention of ABs and facilitated their continuous release.In a murine model of acute endometrial damage and a rat model of IUAs,in situ injection of the AB-laden HA hydrogel could efficiently reduce fibrosis and promote endometrial regeneration,resulting in the fertility restoration.Consequently,ABs show good potential as therapeutic vesicles,and the AB-laden HA hydrogel appears to be a clinically feasible and cell-free alternative for endometrial regeneration and IUA treatment. | Liaobing Xin Cheng Wei Xiaomei Tong Yangyang Dai Dong Huang Jianmin Chen Lie Ma Songying Zhang | 2022 | Bioactive Materials2022，7，6： | 1 |
| 20 | Moment resistance of steel I-beam to CFT column connections 显示文摘 | Chicw S P Lie S T Dai C W | 2001 | Journal of Structural Engineering2001，127，10： | 1 |
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