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| 1 | Features of extrahepatic metastasis after radiofrequency ablation for hepatocellular carcinoma显示文摘BACKGROUND Extrahepatic metastasis(EHM)of hepatocellular carcinoma(HCC)is associated with poor outcomes.However,the clinical features and risk factors of EHM of HCC after radiofrequency ablation(RFA)remain unclear.AIM To elucidate the characteristics and risk factors of EHM after RFA for HCC.METHODS From January 2008 to December 2017,we retrospectively enrolled 661 patients who underwent RFA as first-line treatment for HCC at 2 tertiary hospitals.The inclusion criteria were age≥18 years,a diagnosis of HCC,and treatment-naivety.Abdominal computed tomography(CT)or magnetic resonance imaging(MRI)and alpha-fetoprotein measurements were routinely performed at 1 mo after RFA and followed-up at intervals of 3-6 mo.Univariate analyses were performed using the chi-squared test or Student’s t-test,and univariate and multivariate analyses were performed via logistic regression,as appropriate.RESULTS EHM was diagnosed in 44 patients(6.7%)during a median follow-up period of 1204 days.The 10-year cumulative rate of HCC recurrence and EHM was 92.7%and 33.7%,respectively.Initial recurrence was most often intrahepatic,and the rate of extrahepatic recurrence at initial recurrence was only 1.2%.The median time to the diagnosis of EHM was 2.68 years,and 68.2%of patients developed EHM within 2 years of the first recurrence,regardless of recurrence-free survival and 75.0%of patients developed EHM within 5 years after first recurrence.EHM was mostly diagnosed via abdominal CT/MRI in 33(75.0%)and 38 of 44 patients(86.4%)with EHM had either positive abdominal CT scan results or serum AFP level elevation.In multivariate analysis,recurrence-free survival<2 years,ablation zone/tumor size<2,and alpha-fetoprotein level>400 IU/mL were associated with a high EHM risk.CONCLUSION EHM occurs following multiple intrahepatic recurrences after RFA and combined contrast-enhanced abdominal CT and serum AFP were useful for surveillance.Patients especially with high-risk factors require close follow-up for EHM. | Jae H Yoon Young J Goo Chae-Jun Lim Sung K Choi Sung B Cho Sang S Shin Chung H Jun | 2020 | World Journal of Gastroenterology2020，26，32： | 3 |
| 2 | Hydrodynamics of spouted and spout-fluidized beds at high temperature 显示文摘 | Ye B Lim C J Grace J R | 1992 | The Canadian Journal of Chemical Engineering1992，70，5： | 2 |
| 3 | Prediction of plant microRNA targets 显示文摘 | Rhoades M W Reinhart B J Lim L P | 2002 | Cell2002，110，4： | 1 |
| 4 | Transpalatal advancement pharyngoplasty outcomes compared with uvulopalatopharygoplasty显示文摘 | WOODSON B T ROBINSON S LIM H J | 2005 | Otolaryngol Head NeckSurg2005，133，： | 1 |
| 5 | Preparation of Ru thin film layer on Si and TaN/Si as diffusion barrier by plasma enhanced atomic layer deposition 显示文摘 | Choi B H Lim Y H Lee J H0 | 2010 | Microelec- tronie Engineering2010，87，： | 1 |
| 6 | Environmentally friendly preparation of pec- fins from agricultural byproducts and their strnctural/rheological char- acterization 显示文摘 | Min B Lim J Ko S | 2011 | Bioresource Technology2011，102，4： | 1 |
| 7 | Advanced concentration gradient cathode material with two-slope for high-energy and safe lithium batteries显示文摘 | Lim B B Yoon S J Park K J | 2015 | Advanced Functional Materials2015，25，29： | 1 |
| 8 | Gradual Postharvest Cooling Reduces Blackening Disorder in ‘ Niitaka ’ Pear( Pyrus pyridolia ) Fruits显示文摘 | Lim B S Kim J K | 2005 | Kor Soc Hort Sci2005，46，5： | 1 |
| 9 | Conserved long noncoding RNAs transcriptionally regulated by Oct4 and Nanog modulate pluri- potency in mouse embryonic stem ceils显示文摘 | Sheik M J Gaughwin PM Lim B | 2010 | RNA2010，16，2： | 1 |
| 10 | A new smith predictor for controlling a process with an integrator and long dead-time显示文摘 | Astrom K J Hang C C Lim B C | 1994 | IEEE Transactions on Automatic Control1994，39，2： | 1 |
| 11 | Formulation Method for Solid-to-beam Transition Finite Elements显示文摘 | Lim J K Song T H Seog B H | | 0，，11： | 1 |
| 12 | Semi-Automatic video segmentation for objecttracking显示文摘 | Lim J Ra J B | 2001 | Proceeding of IEEE International Conference onImage Processing2001，，2： | 1 |
| 13 | Effecl of KAI1/CD82 on the beta1 integrin maturation in highly migratory carcinoma cells显示文摘 | Joe B K Lee J Y Lim Y | 2007 | Biochem Biophys Res Commun2007，359，3： | 1 |
| 14 | Metal-insulator transition-induced electrical oscillation in vanadium dioxide thin film显示文摘 | Lee Y W Kim B J Lim J W | 2008 | Applied Physics Letters2008，92，16： | 1 |
| 15 | Sonographic findings of solid and papillary epitheal neoplasm of the pancreas 显示文摘 | Lee D H Yi B H Lim J W | 2001 | J Ultrsound Med2001，20，11： | 1 |
| 16 | A two-photon excited luminescence of water-soluble rhodamine platinum (II) complex: fluorescent probe specific for Hg2 detection in live cell显示文摘 | Zhang J F Lim C S Cho B R | 2010 | Talanta2010，83，： | 1 |
| 17 | Laparoscopicassisted endoscopic sigmoidopexy:a new surgical option for sigmoid volvulus显示文摘 | Gordon-Weeks AN Lorenzi B Lim J | | 0，，05： | 1 |
| 18 | Conserved long noncoding RNAs transcriptionally regulated by Oct4and Nanog modulate pluripotency in mouse embryonic stem cells显示文摘 | SHEIK MOHAMED J GAUGHWIN P M LIM B | 2010 | RNA2010，16，： | 1 |
| 19 | Korean Panic Disorder Severity Scale:construct Validity by Confirmatory factor analysis显示文摘 | Lim Y J Yu B H Kim J H | 2007 | Depression and Anxiety2007，24，： | 1 |
| 20 | Measurements and predictions of the air distribution systems in high compute density (Internet) data centers显示文摘 | CHO J LIM T KIM B S | 2009 | Energy and Buildings2009，41，10： | 1 |
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