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| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | Photochemical responses and oxidative stress in the clones of Coffea canephora under water deficit conditions显示文摘 | Lima A L S DaMatta F M Pinheiro H A | 2002 | Environmental and Experimental Botany2002，47，23： | 1 |
| 3 | Photochemical responses and oxidative stress in two clones of Coffea canephora under water deficit conditions显示文摘 | LIMA A L S DAMATT F M PINHEIRO H A | 2002 | Environmental and Experimental Botany2002，47，： | 1 |
| 4 | Serolog- ic marker candidates among B-cell linear epitopes of Nsp2 and structural proteins of a North American strain of porcine re- productive and respiratory syndrome virus 显示文摘 | DE LIMA M PATTNAIK A K FLORES E F | 2006 | Virology2006，353，2： | 1 |
| 5 | Anionic flotation of railings of manganese ore 显示文摘 | Lima R M F Vasconcelos J A da Silva G R | 2008 | Rem-revista Escolade Minas2008，61，3： | 1 |
| 6 | A new Fusarium lineage within the Gibberellafujikuroi species complex is the main causal agent of mango malformation disease in Brazil显示文摘 | LIMA C S PFENNING L H COSTA S S CAMPOS M A LESLIE J F | 2009 | Plant Pathology2009，58，： | 1 |
| 7 | Evaluation of the matimicrobial effect of photodynmnic antimicrobial therapy in an in situ model of dentine caries显示文摘 | Lima J P Sampaio-de-Melo M A Borges F M | 2009 | Eur J Oral Sci2009，117，5： | 1 |
| 8 | Pectin-coated chi-tosan microgels crosslinked on superhydrophobic surfaces for5-fluorouracil encapsulation显示文摘 | Puga A M Lima A C Mano J F | 2013 | Carbohydr Polym2013，98，1： | 1 |
| 9 | TODIM: Basics and application to multicriteria ranking of projects with environmental impacts显示文摘 | Gomes L F A M Lima M M P P | 1992 | Foundations of Computing and Decision Sciences1992，16，4： | 1 |
| 10 | Microstructural an- alyses and wear behavior of the cemented carbide tools after laser surface treatment and PVD coating 显示文摘 | Neves D Diniz A E Lima M S F | 2013 | Ap- plied Surface Science2013，282，： | 1 |
| 11 | Effect of source of supplemental selenium on uterine health and embryo quality in high-producing dairy cows显示文摘 | Cerri R L A Rutigliano H M Lima F S | 2009 | Theriogenology2009，71，7： | 1 |
| 12 | Serologic marker candidates identified among B-cell linear epitopes of Nsp2 and structural proteins of a North American strain of porcine reproductive and respiratory syndrome virus显示文摘 | DE LIMA M PATTNAIK A K FLORES E F | 2006 | Virol- ogy2006，353，2： | 1 |
| 13 | Luminescent properties and lattice defects correlation on zinc oxide显示文摘 | Lima S A M Sigoli F A Jafelicci M | 2001 | International Journal of Inorganic Materials2001，，3： | 1 |
| 14 | Oxygen reduc- tion reaction on nanosized manganese oxide particles dispersed on carbon in alkaline solutions显示文摘 | CALEGARO M L LIMA F H B TICIANELLI E A | 2006 | J Power Sources2006，158，1： | 1 |
| 15 | Influence of aerobic training on cardiovascular and metabolic parameters in ederly hypertensive women 显示文摘 | Braz N F Carneiro M V Oliveira-Ferreira F Arrieiro A N Amorim F T Lima M M | 2012 | Int J Prev Med2012，3，： | 1 |
| 16 | Impact of genetically modified Enterobacter cloacae on indigenous endophytic community of Citrus sinensis seedlings显示文摘 | Andreote F D Gullo M J M de Souza Lima A O | 2004 | Journal of Microbiology2004，42，3： | 1 |
| 17 | Serologic marker candidates identified among B-cell linear epitopes of Nsp2 and structural proteins of a North American strain of porcine repro ductive and respiratory syndrome virus显示文摘 | De Lima M Pattnaik A K Flores E F | 2006 | Virology2006，353，： | 1 |
| 18 | The Wnt signaling pathway and rheumatoid arthritis显示文摘 | Rabelo F D da Mota L M Lima R A | 2010 | Autoimmun Rev2010，9，4： | 1 |
| 19 | Liquid - liquid extraction of proteases from fermented broth by PEG/citrate aqueous two-phase system 显示文摘 | Porto T S Silva G M M Porto C S Cavalcanti M T H Neto B B Lima F J L Converti A Porto A L F Pessoa J A | 2008 | Chemical Engineering and Processing2008，47，4： | 1 |
| 20 | Serologic marker candidates identified among B-cell linear epitopes of Nsp2 and structural proteins of a North American strain of porcine reproductive and respiratory syndrome virus显示文摘 | de Lima M Pattnaik A K Flores E F | 2006 | Virology2006，353，2： | 1 |
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