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| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | Third-generation nephrectomy by natural orifice transluminal endoscopic surgery显示文摘 | Lima E Rolanda C Pego J M Henriques-Coelho T Silva D Osorio L | 2007 | J Urol2007，178，： | 1 |
| 3 | 显示文摘 | Lima M D de Andrade M J Bergmann C P | 2008 | J Mater Chem2008，18，： | 1 |
| 4 | Model structure determination in neural network models显示文摘 | E L Lima D E Seborg | 2000 | Chemical Engineering Science2000，55，22： | 1 |
| 5 | One-step RT-PCR protocols improve the rate of dengue diagnosis com- pared to two-step RT-PCR approaches显示文摘 | De Paula S O D Lima C D M Torres M P | 2004 | J Clin Virol2004，30，： | 1 |
| 6 | Adsorption modeling of Cr,Cd and Cu on activa- ted carbon of different origins by using fractional factorial design 显示文摘 | De Lima L S Araujo M D M QuinOia S P | 2011 | Chemical Engineering Jour- nal2011，166，3： | 1 |
| 7 | A Comprehensive Strategy to Boost the Quantum Yield of Luminescence of Europium Complexes 显示文摘 | Lima N B D Gonqalves S M C Jtnior S A | 2013 | Sci Rep2013，3，： | 1 |
| 8 | Comparative studies of fungal degradation of single or mixed bioaccesi- ble reactive azo dyes显示文摘 | M Adosinda M Martins Nelson Lima Armando J D Silvestre | 2003 | Chemosphere2003，52，6： | 1 |
| 9 | Rodlike cellulose microcrystals:structure,properties,and applications显示文摘 | Lima M M D Borsali R | 2004 | Macromolecular Rapid Communications2004，25，7： | 1 |
| 10 | Preparation and properties of hy- drophobic layered silicate-reinforced UV-curable poly ( urethane ac- rylate) nanocomposite films for packaging applications显示文摘 | Kima D Lima M Kima I | 2014 | Progress in Organic Coatings2014，77，6： | 1 |
| 11 | A phase Ⅱ trial of perifosine in locally advanced, unresectable, or metastatic pancreatic adenocarcinoma 显示文摘 | Marsh Rde W Rocha Lima C M Levy D E | 2007 | Am J Clin Oncol2007，30，1： | 1 |
| 12 | IgG fe receptors provide an alternative infection route for murine gamma-herpesvirus-68显示文摘 | Rosa G T Gillet L Smith C M de Lima B D Stevenson P G | 2007 | PLoS ONE2007，2，： | 1 |
| 13 | A prospec- tive, comparative study between endoscopic cyclophotocoagutation and the Ahmed drainage implant in refractory glaucoma显示文摘 | LIMA F E MAGACHO L CARVALHO D M | 2004 | J Glaucoma2004，13，3： | 1 |
| 14 | Microstructural an- alyses and wear behavior of the cemented carbide tools after laser surface treatment and PVD coating 显示文摘 | Neves D Diniz A E Lima M S F | 2013 | Ap- plied Surface Science2013，282，： | 1 |
| 15 | Secondary hyperalgesiain the monoarthritic rat is mediated by GABABand NK 1re-ceptors of spinal dorsal horn neurons:a behavior and c-fosstudy显示文摘 | Castro A R Pinto M Lima D | 2006 | Neuroscience2006，41，4： | 1 |
| 16 | Monitoring program for the first steel catenary riser installed in a moored floating platform in deep water显示文摘 | Machado R Z Mourelle M M Franciss R Silva R M Lima C S Eisemberg R Oliveira D | 1999 | Oceans Conference Record (IEEE)1999，2，： | 1 |
| 17 | Conventional and high-dose daunorubiein and idarubicin in acute myeloid leukaemia remission induction treatment: a mixed treatment comparison meta-analysis of 7258 patients 显示文摘 | SEKINE L MORAIS V D LIMA K M | 2014 | Hematol On- col2014，，： | 1 |
| 18 | Impact of genetically modified Enterobacter cloacae on indigenous endophytic community of Citrus sinensis seedlings显示文摘 | Andreote F D Gullo M J M de Souza Lima A O | 2004 | Journal of Microbiology2004，42，3： | 1 |
| 19 | ATPase activity of Mycobacterium tuberculosis SecA1 and SecA2 proteins and its importance for SecA2 function in macrophages显示文摘 | Hou JM D'Lima NG Rigel NW Gibbons HS McCann JR Braunstein M Teschke CM | 2008 | J Bacteriol2008，190，14： | 1 |
| 20 | The Wnt signaling pathway and rheumatoid arthritis显示文摘 | Rabelo F D da Mota L M Lima R A | 2010 | Autoimmun Rev2010，9，4： | 1 |
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