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| 1 | Pediatric functional constipation treatment with Bifi dobacterium-containing yogurt:A crossover,double-blind,controlled trial显示文摘AIM: To evaluate the treatment of pediatric functional chronic intestinal constipation (FCIC) with a probiotic goat yogurt. METHODS: A crossover double-blind formula-controlled trial was carried out on 59 students (age range: 5-15 years) of a public school in Belo Horizonte, MG, Brazil, presenting a FCIC diagnostic, according to Roma Ⅲ criteria. The students were randomized in two groups to receive a goat yogurt supplemented with 109 colony forming unit/mL Bifidobacterium longum (B.longum) (probiotic) daily or only the yogurt for a period of 5 wk (formula). Afterwards, the groups were intercrossed for another 5 wk. Defecation frequency, stool consistency and abdominal and defecation pain were assessed.RESULTS: Both treatment groups demonstrated improvement in defecation frequency compared to baseline. However, the group treated with probiotic showed most signif icant improvement in the f irst phase of the study. An inversion was observed after crossing over, resulting in a reduction in stool frequency when this group was treated by formula. Probiotic and formula improved stool consistency in the f irst phase of treatment, but the improvement obtained with probiotic was significantly higher (P = 0.03). In the second phase of treatment, the group initially treated with probiotic showed worseningstool consistency when using formula. However, the difference was not signif icant. A signif icant improvement in abdominal pain and defecation pain was observed with both probiotic and formula in the first phase of treatment, but again the improvement was more signif icant for the group treated with B. longum during phase I (P < 0.05). When all data of the crossover study were analyzed, significant differences were observed between probiotic yogurt and yogurt only for defecation frequency (P = 0.012), defecation pain (P = 0.046) and abdominal pain (P = 0.015). | Paula VP Guerra Luiza N Lima Tassia C Souza Vanessa Mazochi Francisco J Penna Andreia M Silva Jacques R Nicoli Elizabet V Guimares | 2011 | World Journal of Gastroenterology2011，17，34： | 25 |
| 2 | Ly49 receptors activate angiogenic mouse DBA+ uterine natural killer cells显示文摘 | Patricia DA Lima Megan M Tu Mir Munir A Rahim Annie R Peng B Anne Croy Andrew P Makrigiannis | 2014 | Cellular & Molecular Immunology2014，11，5： | 3 |
| 3 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 4 | Effects of resistance training on the lipid profile in obese women显示文摘 | Costa R R Lima Alberton C Tagliari M Martins Kruel L F | 2011 | Journal of Sports Medicine and Physical Fitness2011，，1： | 2 |
| 5 | Suppression of Chaos by Resonant parametric perturbations显示文摘 | Lima R Pettini M | 1990 | Phys Rev A1990，，41： | 1 |
| 6 | Anionic flotation of railings of manganese ore 显示文摘 | Lima R M F Vasconcelos J A da Silva G R | 2008 | Rem-revista Escolade Minas2008，61，3： | 1 |
| 7 | Population dynamics of rice rats (a Hantavirus reservoir) in southern Chile: feedback structure and non-linear effects of climatic oscillations显示文摘 | Murua R Gonzalez L A Lima M | 2003 | Oikos2003，102，11： | 1 |
| 8 | Microstructural characteristics of cold-sprayed nanostructured WC-Co coatings显示文摘 | Lima R S Karthikeyan J Kay C M | 2002 | Thin Solid Films2002，，416： | 1 |
| 9 | Prevalence and nonrandom distribution of exonic mutations in inter-feron regulatory factor 6 in 307 families with Van der Woude syndrome and 37 families with popliteal pterygium syndrome显示文摘 | de LIMA R L HOPER S A GHASSIBE M | 2009 | Genet Med2009，11，： | 1 |
| 10 | Efficacy of low--level laser therapy and aluminum hydroxide in pa- tients with chemotherapy and radiotherapy-induced oral mucositis显示文摘 | Lima A G Antequera R Peres M P | 2010 | Braz Dent J2010，21，3： | 1 |
| 11 | ln vivo and in vitro studies on the anticancer activity of Copaifera multijuga Hayne and its fractions显示文摘 | Lima S R M Junior V F V Christo H B | 2003 | Phytotherapy Research2003，17，9： | 1 |
| 12 | Assessing therapeutic responsesin Kras mutant cancers using genetically engineerred mouse mod-els显示文摘 | Singh M Lima A Molina R | 2010 | Nat Biotechnol2010，28，6： | 1 |
| 13 | Particle filter with differential evolution for trajecttry tracking 显示文摘 | DE LIMA L M KROHLING R A | 2011 | Advances in Intelligent and Soft Computing2011，96，1： | 1 |
| 14 | Rodlike cellulose microcrystals:structure,properties,and applications显示文摘 | Lima M M D Borsali R | 2004 | Macromolecular Rapid Communications2004，25，7： | 1 |
| 15 | Quantification of biological nitrogen fixation associated with sugarcane using a 15N aided nitrogen balance显示文摘 | LIMA E BODDEY R M DBEREINER J | 1997 | Soil Biol Biochem1997，19，： | 1 |
| 16 | Nuclear magnetic resonance and water activity in measuring the water mobility in Pintado (Pseudoplatystoma corruscans) fish显示文摘 | P1TOMBO R N M LIMA G A M R | 2003 | Journal of Food Engineering2003，58，1： | 1 |
| 17 | ZnO architec- tures synthesized by a microwave-assisted hydrothermal method and their photoluminescence properties显示文摘 | Moura A P Lima R C Moreira M L | 2010 | Solid State Ionics2010，181，1516： | 1 |
| 18 | Mierostructural characteristics of eold-sprayed nanostructured WC-Co coatings显示文摘 | Lima R S Karthikeyan J Kay C M | 2002 | Thin Solid Films2002，416，12： | 1 |
| 19 | Effect of heat treatment on the microstructure of spray formed AISI M2 high-speed steel 显示文摘 | Lima R M Jesus E R B Rossi J L | 2003 | Materials Science Forum2003，，： | 1 |
| 20 | Effect of combined ensiling of sorghum and soybean with or without molasses and lactobacilli on silage quality and in vitro rumen fermentation显示文摘 | Lima R Lourenco M Diaz R F | 2010 | Animal Feed Science and Technology2010，155，2： | 1 |
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