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| 1 | Embolization of splenorenal shunt associated to portal vein thrombosis and hepatic encephalopathy显示文摘Hepatic encephalopathy(HE)is a cognitive disturbance characterized by neuropsychiatric alterations.It occurs in acute and chronic hepatic disease and also in patients with portosystemic shunts.The presence of these portosystemic shunts allows the passage of nitrogenous substances from the intestines through systemic veins without liver depuration.Therefore,the embolization of these shunts has been performed tocontrol HE manifestations,but the presence of portal vein thrombosis is considered a contraindication.In this presentation we show a cirrhotic patient with severe HE and portal vein thrombosis who was submitted to embolization of a large portosystemic shunt.Case report:a 57 years-old cirrhotic patient who had been hospitalized many times for persistent HE and hepatic coma,even without precipitant factors.She had a wide portosystemic shunt and also portal vein thrombosis.The abdominal angiography confirmed the splenorenal shunt and showed other shunts.The larger shunt was embolized through placement of microcoils,and the patient had no recurrence of overt HE.There was a little increase of esophageal and gastric varices,but no endoscopic treatment was needed.Since portosystemic shunts are frequent causes of recurrent HE in cirrhotic patients,portal vein thrombosis should be considered a relative contraindication to perform a shunt embolization.However,in particular cases with many shunts and severe HE,we found that one of these shunts can be safely embolized and this procedure can be sufficient to obtain a good HE recovery.In conclusion,we reported a case of persistent HE due to a wide portosystemic shunt associated with portal vein thrombosis.As the patient had other shunts,she was successfully treated by embolization of the larger shunt. | Letícia de Campos Franzoni Fábio Cardoso de Carvalho Rafael Gomes de Almeida Garzon Fábio da Silva Yamashiro Laís Augusti Lívia Alves Amaral Santos Mariana de Souza Dorna Júlio Pinheiro Baima Talles Bazeia Lima Carlos Antonio Caramori Giovanni Faria Silva Fernando Gomes Romeiro | 2014 | World Journal of Gastroenterology2014，20，42： | 6 |
| 2 | Sex-specific effects of Eugenia punicifolia extract on gastric ulcer healing in rats显示文摘AIM To evaluate the sex-specific effects of a hydroalcoholic extract from Eugenia punicifolia(HEEP) leaves on gastric ulcer healing.METHODS In this rat study involving males, intact(cycling) females, and ovariectomized females, gastric ulcers were induced using acetic acid. A vehicle, lansoprazole, or HEEP was administered for 14 d after ulcer induction. Body weight was monitored throughout the treatment period. At the end of treatment, the rats were euthanized and the following in vivo and in vitro investigations were performed: macroscopic examination of the lesion area and organ weights, biochemical analysis, zymography, and evaluation of protein expression levels. Additionally, the concentration-dependent effect of HEEP was evaluated in terms of subacute toxicity and cytotoxicity.RESULTS Compared to the vehicle, HEEP demonstrated a great healing capacity by substantially reducing the ulcerative lesion area in males(52.44%), intact females(85.22%), and ovariectomized females(65.47%), confirming that HEEP accelerates the healing of acetic acidinduced gastric lesions and suggesting that this effect is modulated by female sex hormones. The antiulcer effect of HEEP was mediated by prostaglandin E2 only in male rats. Overall, the beneficial effect of HEEP was the highest in intact females. Notably, HEEP promoted the expression of vascular endothelial growth factor(intact vs ovariectomized females) and decreased the expression of Caspase-8 and Bcl-2(intact female vs male or ovariectomized female). Additionally, HEEP enhanced fibroblast proliferation and migration into a wounded area in vitro, confirming its healing effect. Finally, no sign of subacute toxicity or cytotoxicity of HEEP was observed.CONCLUSION In gastric ulcers, HEEP-induced healing(modulated by female sex hormones; in males, mediated by prostaglandin) involves extracellular matrix remodeling, with gastric mucosa cell proliferation and migration. | Larissa Lucena Périco Vinícius Peixoto Rodrigues Rie Ohara Gabriela Bueno Vania Vasti Alfieri Nunes Raquel Cássia dos Santos Ana Carolina Lima Camargo Luis Antuio Justulin Joior Sérgio Faloni de Andrade Viviane Miranda Bispo Steimbach Luísa Mota da Silva Lúcia Regina Machado da Rocha Wagner Vilegas Catarina dos Santos Clélia Akiko Hiruma-Lima | 2018 | World Journal of Gastroenterology2018，24，38： | 3 |
| 3 | A hysteretic model for a vanadium dioxide transitionedge microbolometer显示文摘 | de Almeida L A L L Deep G S Lima A M N | 2001 | IEEE Trans Instrum Meas2001，50，4： | 2 |
| 4 | Photochemical responses and oxidative stress in the clones of Coffea canephora under water deficit conditions显示文摘 | Lima A L S DaMatta F M Pinheiro H A | 2002 | Environmental and Experimental Botany2002，47，23： | 1 |
| 5 | Photochemical responses and oxidative stress in two clones of Coffea canephora under water deficit conditions显示文摘 | LIMA A L S DAMATT F M PINHEIRO H A | 2002 | Environmental and Experimental Botany2002，47，： | 1 |
| 6 | Properties of alumina-titania coatings prepared by laser-assisted air plasma spraying 显示文摘 | Dubourg L Lima R S Moreau C | 2007 | Surface and Coatings Technology2007，201，14： | 1 |
| 7 | Study of catalyst deactivation and reaction mechanism of steam reforming,partial oxidation,and oxidative steam reforming of ethanol over Co/CeO2 catalyst显示文摘 | de Lima S M da Silva A M da Costa L O O | 2009 | J Catal2009，268，2： | 1 |
| 8 | Nanocasted oxides for gas phase glycerol conversion显示文摘 | LIMA C L VASCONCELOS S J S FILHO J M | 2011 | Appl Catal A: General2011，599，： | 1 |
| 9 | Prevalence and nonrandom distribution of exonic mutations in inter-feron regulatory factor 6 in 307 families with Van der Woude syndrome and 37 families with popliteal pterygium syndrome显示文摘 | de LIMA R L HOPER S A GHASSIBE M | 2009 | Genet Med2009，11，： | 1 |
| 10 | A novel preisach operator for modeling of hysterisi in VO2 microbolometer显示文摘 | Almeida L A L Deep G S Lima A M N | 2002 | IEEE Instrumentation and Measurement Technology2002，1，2123： | 1 |
| 11 | Adsorption modeling of Cr,Cd and Cu on activa- ted carbon of different origins by using fractional factorial design 显示文摘 | De Lima L S Araujo M D M QuinOia S P | 2011 | Chemical Engineering Jour- nal2011，166，3： | 1 |
| 12 | The endocannabinoid system in renal cells: regulation of Na+ transport by CB1 receptors through distinct cell signaling pathways显示文摘 | Sampaio L S Taveira Da Silva R Lima D | 2015 | Br J Pharmacol2015，172，19： | 1 |
| 13 | Soliton and quasi-soliton swithing in nonlinear optical loop mirror constructed from dispersion decreasing fiber 显示文摘 | Lima J L S Sombra A S B | 1999 | Optics Communication1999，163，： | 1 |
| 14 | A new Fusarium lineage within the Gibberellafujikuroi species complex is the main causal agent of mango malformation disease in Brazil显示文摘 | LIMA C S PFENNING L H COSTA S S CAMPOS M A LESLIE J F | 2009 | Plant Pathology2009，58，： | 1 |
| 15 | Use of the ASA physical status system in pediatric practice 显示文摘 | Aplin S Baines D l)e Lima J | 2007 | Paediatr Anaesth2007，17，3： | 1 |
| 16 | Development of a DNA-based vaccine strategy against bovine papil- lomavirus infection,involving the E5 or L2 gene显示文摘 | Lima E G Lira R C Jesus A L S | 2014 | Genet Mol Res2014，13，1： | 1 |
| 17 | Chemical fraction of phosphorus, sulfur, and molybdenum in Brazilian savannah Oxisols under different land use 显示文摘 | Lilienfein J Wilcke W Ayarza M A Vilela L Lima S C and Zech W | 2000 | Geoderma2000，96，： | 1 |
| 18 | 显示文摘 | Pavan F A Dias S L P Lima E C | 2008 | Dyes Pigments2008，76，： | 1 |
| 19 | Cathepsin B and Dac-tivity and activity ratios in normal ovaries,benign ovarian neo-plasms and epithelial ovarian vancer显示文摘 | DOWNS L S LIMA P H BLISS R L | 2005 | Soc Gynecol Invesity2005，12，7： | 1 |
| 20 | 显示文摘 | de Lima A L Mbengue A San Gil R A S | 2014 | Catalysis Today2014，226，： | 1 |
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