|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Embolization of splenorenal shunt associated to portal vein thrombosis and hepatic encephalopathy显示文摘Hepatic encephalopathy(HE)is a cognitive disturbance characterized by neuropsychiatric alterations.It occurs in acute and chronic hepatic disease and also in patients with portosystemic shunts.The presence of these portosystemic shunts allows the passage of nitrogenous substances from the intestines through systemic veins without liver depuration.Therefore,the embolization of these shunts has been performed tocontrol HE manifestations,but the presence of portal vein thrombosis is considered a contraindication.In this presentation we show a cirrhotic patient with severe HE and portal vein thrombosis who was submitted to embolization of a large portosystemic shunt.Case report:a 57 years-old cirrhotic patient who had been hospitalized many times for persistent HE and hepatic coma,even without precipitant factors.She had a wide portosystemic shunt and also portal vein thrombosis.The abdominal angiography confirmed the splenorenal shunt and showed other shunts.The larger shunt was embolized through placement of microcoils,and the patient had no recurrence of overt HE.There was a little increase of esophageal and gastric varices,but no endoscopic treatment was needed.Since portosystemic shunts are frequent causes of recurrent HE in cirrhotic patients,portal vein thrombosis should be considered a relative contraindication to perform a shunt embolization.However,in particular cases with many shunts and severe HE,we found that one of these shunts can be safely embolized and this procedure can be sufficient to obtain a good HE recovery.In conclusion,we reported a case of persistent HE due to a wide portosystemic shunt associated with portal vein thrombosis.As the patient had other shunts,she was successfully treated by embolization of the larger shunt. | Letícia de Campos Franzoni Fábio Cardoso de Carvalho Rafael Gomes de Almeida Garzon Fábio da Silva Yamashiro Laís Augusti Lívia Alves Amaral Santos Mariana de Souza Dorna Júlio Pinheiro Baima Talles Bazeia Lima Carlos Antonio Caramori Giovanni Faria Silva Fernando Gomes Romeiro | 2014 | World Journal of Gastroenterology2014，20，42： | 6 |
| 2 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 3 | Propolis antimicrobial activity against periodontopathic bacteria显示文摘 | Gebara ECE Lima LA Mayer MPA | 2002 | Brazilian Journal of Microbiology2002，33，4： | 1 |
| 4 | Spinal cord compression by ectopic calcinosis in scleroderma显示文摘 | Lima Ⅳ Galrao LA Maia TS | 2005 | Clin Exp Rheumatol2005，23，5： | 1 |
| 5 | Identification of anovel antimicrobial peptide from Brazilian coast coral Phyllogorgiadilatata显示文摘 | de Lima LA Migliolo L Barreiro e Castro C | 2013 | Protein Pept Lett2013，20，10： | 1 |
| 6 | Assessment of heavy metal levels in Almendares River sediments -Havana City, Cuba显示文摘 | OLIVARES-RIEUMONT S DE LA ROSA D LIMA L | 2005 | Water Research2005，，39： | 1 |
| 7 | Predictors of tooth loss dur- ing long-term periodontal maintenance: a systematic review of obser-vational studies显示文摘 | Chambrone L Chambrone D Lima LA | 2010 | J Clin Periodontol2010，37，7： | 1 |
| 8 | Traumatic subdural hygromas: proposed pathogenesis based classification 显示文摘 | Zanini MA de Lima Resende LA de Souza Faleiros AT | 2008 | J Trauma2008，64，3： | 1 |
| 9 | The worldwide prevalence of ADHD: a systematic review and metaregression analysis 显示文摘 | Polanczyk G de Lima MS Horta BL Biederman J Rohde LA | 2007 | Am J Psychiatry2007，164，6： | 1 |
| 10 | SARS-CoV-2 productively infects primary human immune system cells in vitro and in CoviD-19 patients显示文摘The severe acute respiratory syndrome coronavirus 2(SARS-CovV-2)infection is associated with a hyperinflammatory state and lymphocytopenia,a hallmark that appears as both signature and prognosis of disease severity outcome.Although cytokine storm and a sustained inflammatory state are commonly associated with immune cell depletion,it is still unclear whether direct SARS-Cov-2 infection of immune cells could also play a role in this scenario by harboring viral replication.We found that monocytes,as well as both B and T lymphocytes,were susceptible to SARS-Cov-2 infection in vitro,accumulating double-stranded RNA consistent with viral RNA replication and ultimately leading to expressive T cell apoptosis.In addition,flow cytometry and immunofluorescence analysis revealed that SARS-Cov-2 was frequently detected in monocytes and B lymphocytes from coronavirus disease 2019(CoVID-19)patients.The rates of SARS-Cov-2-infected monocytes in peripheral blood mononuclear cells from CoVID-19 patients increased over time from symptom onset,with SARS-CoV-2-positive monocytes,B cells,and CD4+T lymphocytes also detected in postmortem lung tissue.These results indicated that SARS-CoV-2 infection of blood-circulating leukocytes in covID-19 patients might have important implications for disease pathogenesis and progression,immune dysfunction,and virus spread within the host. | Marjorie C.Pontelli italo A.Castro Ronaldo B.Martins Leonardo La Serra Flavio P.Veras Daniele C.Nascimento Camila M.Silva Ricardo S.Cardoso Roberta Rosales Rogério Gomes Thais M.Lima Juliano P.Souza Brenda C.Vitti Diego B.Caetite Mikhael H.F.de Lima Spencer D.Stumpf Cassandra E.Thompson Louis-Marie Bloyet Juliana E Toller-Kawahisa Marcela C.Giannini Leticia P.Bonjorno Marial.F.Lopes Sabrina S.Batah Li Siyuan Rodrigo Luppino-Assad Sergio C.L.Almeida Fabiola R.Oliveira Maira N.Benatti Lorena L.F.Pontes Rodrigo C.Santana Fernando C.Vilar Maria Auxiliadora-Martins Pei-Yong Shi Thiago M.Cunha Rodrigo T.Calado JoséC.Alves-Filho Dario S.Zamboni Alexandre T.Fabro Paulo Louzada-Junior Rene D.R.Oliveira Sean P.J.Whelan Fernando Q.Cunha Eurico Arruda | 2022 | Journal of Molecular Cell Biology2022，14，4： | 1 |
| 11 | Assessment of heavy metal levels in Almendares River sediments -Havana City, Cuba显示文摘 | Susana Olivares-Rieumont Daniel de la Rosa Lazaro Lima | 2005 | Water Research2005，39，： | 1 |
| 12 | Assessment of heavy metal levels in Almendares River sediments-Havana City, Cuba显示文摘 | Olivares-Rieumont S De La Rosa D Lima L | 2005 | Water Research2005，39，16： | 1 |
| 13 | Chronic cerebrovascular ischemia in aged rats:effects on brain metabolic capacity and behavior显示文摘 | Cada A de la Torre JC Gonzalez Lima F | 2000 | Neurobiol Aging2000，21，2： | 1 |
| 14 | Pyelocalicial diverticula显示文摘 | LIMA E LA FUENTE J GARCIA-CUERPO E | 2000 | Arch Esp Urol2000，53，7： | 1 |
| 15 | Predictors of tooth loss during long-term periodontal maintenance:a systematic review of observational studies显示文摘 | Chambrone L Chambrone D Lima LA | 2010 | J Clin Periodontol2010，37，7： | 1 |
| 16 | Predictors of tooth loss during long-term periodontal maintenance: a systematic review of observational studies 显示文摘 | Chambrone L Chambrone D Lima LA | 2010 | J Clin Periodontol2010，37，7： | 1 |
| 17 | Traumatic subdural hygromas: proposed pathogene- sis based classification 显示文摘 | Zanini MA de Lima Resende LA de Souza Faleiros AT | 2008 | J Trauma2008，64，3： | 1 |
| 18 | Propolis extract as an adjuvant to periodontal treatment 显示文摘 | Gebaraa EC Pustiglioni AN de Lima LA | 2003 | Oral Health Prev Dent2003，1，1： | 1 |
| 19 | Pyelocalicial diverticula 显示文摘 | LIMA E LA FUENTE J GARCIA CUERPO E | 2000 | Arch Esp Urol2000，53，7： | 1 |
| 20 | Propolis extract as an adjuvant to periodontal treatment显示文摘 | GEBARA EC PUSTIGLION AN DE LIMA LA | 2003 | Oral Health Prey Dent2003，1，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员