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| 1 | Clinical Features of Adult/Adolescent Atopic Dermatitis and Chinese Criteria for Atopic Dermatitis显示文摘 | Ping Liu Yan Zhao Zhang-Lei Mu Qian-Jin Lu Qian-Jin L U Li Zhang Xu Yao Min Zheng Yi-Wen Tang Xin-Xiano Lu Xiu-Juan xia You-Kun Lin Yu-Zhen Li Cai-Xia Tu Zhi-Rong Yao Jin-Hua Xu Wei Li Wei Lai Hui-Min Yang Hong-Fu Xie Xiu-Ping Han Zhi-Qiang Xie Xiang Nong Zai-Pei Guo Dan-Qi Deng Tong-Xin Shi Jian-Zhong Zhang | 2016 | Chinese Medical Journal2016，，7： | 64 |
| 2 | 帕博利珠单抗单用或与放疗联用治疗转移性非小细胞肺癌:两个随机试验的汇总分析显示文摘背景放疗可以提高整个机体对免疫治疗的应答。在Ⅱ期PEMBRO-RT研究和Ⅰ/Ⅱ期MDACC研究中,患有转移性非小细胞肺癌(NSCLC)的患者被随机分配入组,接受免疫治疗(帕博利珠单抗)+放疗联合疗法,或免疫治疗单一疗法。当上述2个研究单独分析时,联合疗法组显示出潜在获益。由于每个研究的样本量较小,缓解率和结局并未显示出统计学意义,然而却有显著的临床获益。因此,本研究进行汇总分析,来判断放疗是否会改善转移性NSCLC患者的免疫治疗应答。方法PEMBRO-RT和MDACC研究纳入标准:患者年龄≥18岁,患有转移性NSCLC,且有≥1处未经放疗照射的病灶,以便进行射野外应答监测。PEMBRO-RT研究纳入曾接受过化疗患者,MDACC研究纳入曾接受过治疗或新诊断患者。2个研究中的患者均未接受过免疫治疗。在PEMBRO-RT研究中患者被等比例随机分配入组,并根据吸烟状态进行分层(分为<10年组和≥10年组)。MDACC研究的患者根据放疗计划可行性被等比例随机分配入2个受试组。由于联合治疗组的干预本质,每个研究中的放疗均不适用盲法。在2个研究中,不论是否进行放疗,均静脉滴入帕博利珠单抗(每3周200 mg)。在PEMBRO-RT研究中,在放疗(24 Gy 3次分割照射)结束后1周给予第1剂帕博利珠单抗。在MDACC研究中,在第1次放疗(50 Gy 4次分割照射或45 Gy 15次分割照射)同时给予帕博利珠单抗。仅检测未经照射病灶的应答。本研究的终点为最佳射野外(远隔)应答率(ARR)、最佳射野外疾病控制率(ACR)、12周时ARR、12周时ACR、无进展生存期(PFS)和总生存期(OS)。2个研究的意向治疗(ITT)人群均纳入分析。PEMBRO-RT研究(NCT02492568)和MDACC研究(NCT02444741)均在ClinicalTrials.gov上注册。发现纳入148例患者,76例接受帕博利珠单抗治疗,72例接受帕博利珠单抗+放疗治疗。所有患者随访时间中位数为33个月[四分位距(IQR):32.4~33.6]。148例患者中124例(84%)组织学特征为非鳞癌,111例(75%)患者曾经接受过化疗。组间没有基线特征差异,包括PD-L1表达状态和转移灶体积。最常见的照射部位为肺转移灶(39%,28/72)、胸腔内淋巴结(21%,15/72)和非原发灶(17%,12/72)。帕博利珠单抗组和联合治疗组的最佳ARR分别为19.7%(15/76)和41.7%(30/72),OR=2.96,95%CI:1.42~6.20,P=0.0039;最佳ACR分别为43.4%(33/76)和65.3%(47/72),OR=2.51,95%CI:1.28~4.91,P=0.0071;PFS中位数分别为4.4(IQR:2.9~5.9)和9.0个月(IQR:6.8~11.2),HR=0.67,95%CI:0.45~0.99,P=0.045;OS中位数分别为8.7(IQR:6.4~11.0)和19.2个月(IQR:14.6~23.8),OR=0.67,95%CI:0.54~0.84,P=0.0004。在汇总分析中没有发现新的安全问题。解读帕博利珠单抗免疫疗法+放疗显著提高转移性NSCLC患者的应答和改善治疗结局。这些结果需要在三期临床试验中进行验证。 | 陈大卫(翻译) 于金明(校对) Willemijn S M E Theelen Vivek Verma Brian P Hobbs Heike M U Peulen Joachim G J V Aerts Idris Bahce Anna Larissa N Niemeijer Joe Y Chang Patricia M de Groot Quynh-Nhu Nguyen Nathan I Comeaux George R Simon Ferdinandos Skoulidis Steven H Lin Kewen He Roshal Patel John Heymach Paul Baas James W Welsh | 2021 | 中华肿瘤防治杂志2021，28，24： | 49 |
| 3 | A preliminary study on correlations of triple-phase multi-slice CT scan with histological differentiation and intratumoral microvascular/lymphatic invasion in gastric cancer显示文摘许多研究显示出的背景那癌症房间区别和 microvascular 侵略在癌症起一个原则作用前进和转移,和象估计区别和外科的 resectibility 和癌症的预后的 CT, MRI 和美国那样的非侵略的成像技术现在是很重要的。这研究试图与组织学的区别和现在的学习包括了的进步胃的 cancer.Methods 的 intratumor microvascular/lymphatic 侵略探索三倍阶段的多片 CT 扫描的关联有胃的癌症的 64 个病人,所有谁在外科前经历了 routinal 和上面的腹部的双阶段的对比改进多片 CT 考试。手术后的标本被用于组织学的区别,容器由 CD34 识别了的 intratumoral microvascular/lyrnphatic 的癌症房间侵略和 D2-40 表示的决心。在在胃的癌症和组织学的区别以及 intraturnoral microvascular/lymphatic 侵略的三倍阶段的多片 CT 扫描的对比改进比率(CER ) 之间的关联被比较,在那里的 analyzed.Results 是在在胃的癌症和肿瘤的三倍阶段的 CT 扫描的 CER 之间的重要关联组织学的区别(P0.05 ) 。没有侵略,在有 intratumoral microvascular 侵略的胃的癌症的动脉的阶段的 CER 比那显著地高(0.61 楶祴椬灭汵楳楶祴愠摮椠慮瑴湥楴湯愠摮瀠瑵 ? 牧慥? 畢摲湥漠 ? 档汩牤湥琠敨獭汥敶 ? 桴楥? 慦業楬獥愠摮琠敨猠' 覕媮聸维樲鏍剾 D 慥敳漠慲? 祳瑳浥洠瑥票灬敨楮慤整 ? 剏协 ??? 獩愠漠据 ? 慤汩 ? 潣瑮潲汬摥爭汥慥敳映牯畭慬楴湯搠癥汥灯摥琠? 癯牥潣敭猠浯 ? 景琠敨氠浩瑩瑡潩獮愠獳' 覒 X 整 ? 楷桴椠浭摥慩整爭汥慥敳洠瑥票灬敨楮慤整 ? 剉??? 瑉栠獡戠敥 ? 慭歲瑥摥椠 ? 桃湩 ? 楳据 ??? 戠瑵猠楴汬氠捡獫搠瑡 ?... | YIN Xin-dao HUANG Wen-bin L(U) Cheng-yu ZHANG Lin WANG Li-wei XIE Guang-hui | 2011 | Chinese Medical Journal2011，，3： | 6 |
| 4 | Rational use of mesenchymal stem cells in the treatment of autism spectrum disorders显示文摘Autism and autism spectrum disorders(ASD) refer to a range of conditions characterized by impaired social and communication skills and repetitive behaviors caused by different combinations of genetic and environmental influences. Although the pathophysiology underlying ASD is still unclear, recent evidence suggests that immune dysregulation and neuroinflammation play a role in the etiology of ASD. In particular, there is direct evidence supporting a role for maternal immune activation during prenatal life in neurodevelopmental conditions. Currently, the available options of behavioral therapies and pharmacological and supportive nutritional treatments in ASD are only symptomatic. Given the disturbing rise in the incidence of ASD, and the fact that there is no effective pharmacological therapy for ASD, there is an urgent need for new therapeutic options. Mesenchymal stem cells(MSCs) possess immunomodulatory properties that make them relevant to several diseases associated with inflammation and tissue damage. The paracrine regenerative mechanisms of MSCs are also suggested to be therapeutically beneficial for ASD.Thus the underlying pathology in ASD, including immune system dysregulation and inflammation, represent potential targets for MSC therapy. This review willfocus on immune dysfunction in the pathogenesis of ASD and will further discuss the therapeutic potential for MSCs in mediating ASD-related immunological disorders. | Qiang Liu Mo-Xian Chen Lin Sun Chloe U Wallis Jian-Song Zhou Li-Juan Ao Qi Li Pak C Sham | 2019 | World Journal of Stem Cells2019，11，2： | 5 |
| 5 | Automated Sequencing and Subassembly Detection in Automobile Body Assembly Planning显示文摘The choice of the sequence in which parts or subass em blies are put together in the mechanical assembly of a product can drastical ly affect the efficiency of the assembly process. Unlike metal cutting operation s where computer aided system have been available for some 15 to 25 years to hel p manufacturing engineers in generating cutting sequences and NC programs, the m ajority of assembly planning tasks in automobile body design is still manually p erformed by assembly designers according to their past experiences. This has prolonged the production lead time and time to market. This paper describes a p rocedure to automatically derive all the feasible assembly sequences for automob ile body assembly. The procedure is based on a mathematical model of the automob ile body, obtained through the definitions of the connection matrix and contract ed matrix. These two matrices represent the precedence constraint knowledge amon g components and subassemblies. The possible subassemblies are automatically det ected by satisfying some mathematical conditions applicable to these matrices. F or each subassembly and the whole product, all the possible assembly sequences a re generated by rearranging the initial connection sub-matrix and the contracte d matrix. The procedure is applicable to compliant component assemblies, suc h as the automobile body assembly, aircraft frame assembly, and can solve the 'combinatorial explosion' problem efficiently. | ZHANG Yi-zhu 1, NI Jun 2, LIN Zhong-qin 1, LAI Xin-min 1 (1. Institute of Mechanics and Engineering, Shanghai Jiaotong Universit y, Shanghai 200030, China 2. Department of Mechanical Engineering, The University of Michigan, Michigan, U SA) | 2002 | 厦门大学学报(自然科学版)2002，41，S1： | 3 |
| 6 | 欧洲和中国的心脏与肾脏远程缺血预适应研究:一项随机对照试验显示文摘远程缺血预适应(remote ischemic preconditioning,RIPC)对经皮冠状动脉介入治疗(percutaneous coronary intervention,PCI)术后造影剂肾病(contrast-induced nephropathy,CIN)的潜在保护作用尚待确定。该研究为双盲、随机、安慰剂对照的多中心研究,纳入年龄〈85岁,肾清除率为30~60mL/(min·1.73m^2)的有临床适应证的患者,除了直接PCI外均按1∶1给予RIPC或标准治疗。主要终点是CIN的发生率。次要终点是围手术期心肌梗死(peri-procedural myocardial infarction,PMI)的发生率。 | 刘青 叶鹏 Moretti C Cerrato E Cavallero E Lin S Rossi ML Picchi A Sanguineti F Ugo F Palazzuoli A Bertaina M Presbitero P Shao-Liang C Pozzi R Giammaria M Limbruno U Lefèvre T Gasparetto V Garbo R OmedèP Sheiban I Escaned J Biondi-Zoccai G Gaita F Perl L D'Ascenzo F | 2018 | 中华高血压杂志2018，26，4： | 3 |
| 7 | Inflow conditions for large-eddy simulations of mixing layers显示文摘 | Lin N Balaras E Piomelli U | 2000 | Physics of Fluids2000，12，4： | 1 |
| 8 | Hereditaryovarian cancer and two-compartment tumor metabolism : epithelialloss of BRCA1 induces hydrogen peroxide production,driving oxi-dative stress and NF kB activation in the tumor stroma 显示文摘 | Martinez-Outschoom U E Balliet R M Lin Z | 2012 | Cell Cycle2012，11，22： | 1 |
| 9 | Identification of tumorigenic retinal stem-like cells in human solid retinoblastomas显示文摘 | Zhong X U Y Peng F Huang B Lin J Zhang W et at | 2007 | Int J Cancer2007，121，10： | 1 |
| 10 | Recognizing E- motions From an Ensemble of Features 显示文摘 | Tariq U Kai - Hsiang Lin Zhen Li | 2012 | IEEE Transac- tions on Systems Man and Cybernetics Part B: Cybernet- ics2012，42，4： | 1 |
| 11 | Ganoderiol F,a ganoderma triterpene,induces senescence in hepatoma HepG2 cells显示文摘 | CHANG U M LI C H LIN L I | 2006 | Life Sci2006，79，12： | 1 |
| 12 | The RNA helicase and nucleotide triphosphatase activities of the Bovine viral diarrhea virus NS3 protein are essential for viral replication显示文摘 | Baohua G U Changbao Liu Juili Lin | 2000 | J Virol2000，74，： | 1 |
| 13 | Modeling and Control of Micropositioning Systems Using Stewart Platforms 显示文摘 | Lin L C Tsay M U | 2000 | Journal of Robotic Systems2000，17，1： | 1 |
| 14 | A rice spotted leaf gene, Spl7, encodes a heat stress transcription factor protein 显示文摘 | YAMANOUCHI U YANO M LIN H | 2002 | Proc Nail Acad Sci USA2002，99，11： | 1 |
| 15 | The effect of alloying element gallium on the polarization characteristics of Pb-free Sn-Zn-Ag-A1-XGa solders in NaCl solution显示文摘 | MOHANTY U S LIN K L | 2006 | Corrosion Science2006，48，3： | 1 |
| 16 | Influence of grain boundary character distribution on sensitization and intergranular corrosion显示文摘 | LIN P PALUMBO G ERB U | 1995 | Scr Metall Mater1995，33，： | 1 |
| 17 | Digital Watermarking of Low Bit- rate Advanced Simple Profile MPEG- 4 Compressed Video 显示文摘 | Alattar A M Lin E T Celik M U | 2003 | IEEE Transactions on Circuits and Systems for Video Technology2003，13，8： | 1 |
| 18 | Analysis and design for discrete-time linear systems subject to actuator Saturation显示文摘 | u T Lin Z Chen B-M | 2002 | Systems & Control Letters2002，45，2： | 1 |
| 19 | Influence of grain boundary character distribution on sensitization and intergranular corrosion of alloy 600 显示文摘 | Lin P Palumbo G Erb U | 1995 | Scripta Metal Mater1995，33，9： | 1 |
| 20 | The chemical and mineralogical behavior of Pb on shooting range soils from Central Sweden显示文摘 | Lin Z Comet B Qvarfort U | 1995 | Environ Pollut1995，89，： | 1 |
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