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| 1 | Upregulation of vimentin and aberrant expression of E-cadherin /beta-catenin complex in oral squamous cell carcinomas:correlation with the clinicopathological features and patient outcome显示文摘Oral squamous cell carcinoma is a challenging oncology problem.A reliable biomarker for metastasis or high-risk prognosis in oral cancer patients remains undefined.Using quantitative immunohistochemistry,we examined the expression of vimentin,E-cadherin,and beta-catenin in 83 oral squamous cell carcinoma patients,and the relationships between the expression of these markers and specific clinicopathological features were analysed.The high expression of vimentin was observed in 23 of 43(53%) tumours from patients who eventually developed a recurrent tumour and was associated with recurrence and death(P < 0.001 and < 0.001,respectively).The decreased expression of E-cadherin was observed in 36 of 43(84%) tumours from patients who eventually developed a recurrent tumour and was also associated with recurrence and death(P < 0.001 and < 0.001,respectively).Although no correlation between beta-catenin expression in whole-tumour sections and clinicopathological features was observed,decreased beta-catenin expression at the tumour invasive front was closely associated with recurrence and death(P=0.002 and 0.002,respectively).The expression of vimentin and that of E-cadherin were associated with survival and were independent prognostic factors in univariate and multivariate analyses.Our data show that the overexpression of vimentin was closely associated with recurrence and death in oral squamous cell carcinoma patients.The combination of the upregulation of vimentin and aberrant expression of E-cadherin/beta-catenin complexes at the tumour invasive front may provide a useful prognostic marker in oral squamous cell carcinoma. | Liu,LK Jiang,XY Zhou,XX Wang,DM Song,XL Jiang,HB Nanjing Med Univ,Coll Stomatol,Dept Oral Pathol,Nanjing 210029,Jiangsu,Peoples R China Nanjing Med Univ,Inst Stomatol,Dept Oral Pathol,Nanjing 210029,Jiangsu,Peoples R China Nanjing Med Univ,Coll Stomatol,Dept Oral & Maxillofacial Surg,Nanjing 210029,Jiangsu,Peoples R China | 2010 | 南京医科大学学报(自然科学版)2010，30，5： | 25 |
| 2 | Over-expression of heat shock protein 27 attenuates doxorubicin-induced cardiac dysfunction in mice显示文摘 | Liu,L Zhang,X Qian,B Min,XY Gao,X Li,CF Cheng,YL Huang,J | 2007 | 南京医科大学学报(自然科学版)2007，27，11： | 15 |
| 3 | 12-Deoxyphorbol Esters from Euphorbia Fischeriana显示文摘12-DeoxyphorbolEstersfromEuphorbiaFischerianaWenZiLIU;XiaoYunWU;GenJinYANG;QingGaoMA;TianXiZHOU;XiCanTANGandGuoWeiQIN(Departm... | Liu, WZ Wu, XY Yang, GJ Ma, QG Zhou, TX Tang, XC Qin, GW | 1996 | Chinese Chemical Letters1996，7，10： | 7 |
| 4 | Antibody detection and sequence analysis of sporadic HEV in Xiamen region显示文摘 | Huang RT Li XY Xia XB Yuan XT Liu MX Li DR | 1999 | World Journal of Gastroenterology1999，5，3： | 6 |
| 5 | 癫痫为首发症状的儿童甲状旁腺功能减退无需抗癫痫药物治疗显示文摘背景癫痫临床表现具有多样化,从不受控制的抽搐运动(强直-阵挛性发作)到瞬间失去知觉(失神发作)。大脑电脉冲传播到大脑相邻区域并产生不受控制的电活动风暴。癫痫发病机制可分为六类:代谢、结构、遗传、免疫、炎症、特发性。甲状旁腺功能减退是一种由于甲状旁腺激素(Parathyroid hormone,PTH)缺失或任何激素功能抵抗导致的内分泌疾病,表现主要包括低钙血症,高磷血症和异常PTH水平。 | 邹丽萍 Liu MJ Li JW Shi XY | 2017 | 癫痫杂志2017，3，2： | 5 |
| 6 | Local signals in stem cell-based bone marrow regeneration显示文摘 | Han W Yu Y Liu XY | 2006 | 中国生物学文摘2006，20，5： | 2 |
| 7 | The influence of genetic polymor- phisms and interacting drugs on initial response to warfarin in Chi- nese patients with heart valve replacement显示文摘 | Zhong SL Liu Y Yu XY | 2011 | Eur J Clin Pharma- col2011，67，6： | 1 |
| 8 | L-type voltage-gated Ca^2+ channel attends regulation of tyrosine phosphorylation of NMDA receptor subunit 2A induced by transient brain ischemia显示文摘 | Liu Y Hou XY Zhang GY | 2003 | Brain Res2003，972，： | 1 |
| 9 | Expression of stromal cell derived factor 1 and CXCR7 in papillary thyroid carcinoma显示文摘 | Liu Z Sun DX Teng XY | 2012 | Endocr Pathol2012，23，4： | 1 |
| 10 | Paricalcitol attenuates renal interstitial fibrosis in obstructive nephropathy显示文摘 | Tan XY Li YJ Liu YH | | 0，，10： | 1 |
| 11 | Brain-Derived Neurotrophic Factor Val66Met Allele Impairs Basal and Ketamine-Stimulated Synaptogenesis in Prefrontal Cortex显示文摘 | Liu RJ Lee FS Li XY | | 0，，： | 1 |
| 12 | Relationship between vertebral artery hypoplasia and posterior circulation stroke in Chinese patients 显示文摘 | Hu XY Li ZX Liu HQ | 2013 | Neuroradiology2013，55，3： | 1 |
| 13 | Phosphate ion targeted colorimetrie and fluorescent probe and its use to monitor endogeneous phosphate ion in a hemichannel-closed cell 显示文摘 | Goo LE Zhang JF Liu XY | 2015 | Analytical Chemistry2015，87，： | 1 |
| 14 | Activation of the canonical nuclear factor-κB pathway is involved in isoflurane-induced hippocampal interleukin-1 ? b elevation and the resultant cognitive deficits in aged rats 显示文摘 | Li ZQ Rong XY Liu YJ | 2013 | Biochem Biophys Res C ommun2013，438，： | 1 |
| 15 | Development and evaluation of lipid microbubbles targeted to alpha(v)beta(3)-integrin via biotin-avidin bridge显示文摘 | Wang W Liu GJ Xie XY | 2012 | J Mieroeneapsul2012，29，2： | 1 |
| 16 | Protective effects of hyperoside (quercetin-3-o-galactoside) to PC12 ceils against cytotoxicity induced by hydrogen peroxide and tertbutyl hydroperoxide显示文摘 | Liu ZY Tao XY Zhang CW | 2005 | Biomed & Pharmacother2005，59，9： | 1 |
| 17 | Captopril Restores Endothelium-Dependent Relaxation Induced by Advanced Oxidation Protein Products in Rat Aorta显示文摘 | Liu LY Sun XY | 2005 | J Cardiovasc Pharmacol2005，46，6： | 1 |
| 18 | In vitro study of the reIationship between the structure of ginsenoside and its antioxidative or prooxidative activity in free radical induced hemoIysis of human erythrocytes显示文摘 | LIU ZQ LUO XY LIU GZ | 2003 | J Agric Food Chem2003，51，25： | 1 |
| 19 | Cytologicai differential diagnosisamong adenocarcinoma,epithelial mesothelioma,and reactivemesothelial cells in serous effusions by immunocytochemistry 显示文摘 | Su XY Li GD Liu WP | 2011 | Diagn Cytopathol2011，39，12： | 1 |
| 20 | Tamoxifen lowers the MMP-9/TIMP-1ratio and inhibits the invasion capacity of ER-positive non-small cell lung cancer cells显示文摘 | Wang XY Wang Y Liu HC | 2011 | Biomedicine and Pharmacotherapy2011，32，1： | 1 |
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