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| 1 | Effects of icariin on cGMP-specific PDE5 and cAMP-specific PDE4 activities显示文摘Aim:To clarify the mechanism of the therapeutic action of icariin on erectlile dysfunction(ED).Methods:PDE5 was isolated from the human platelet and PDE4 form the rat liver tissue using the FPLC system (Pharmacia,Milton Keynes,UK)and the Mono Q column.The inhibitory effects of icariin on PDE5 and PDE4 activities were investigated by the two-step radioisotope procedure with [^3H]-c GMP/[^3H]-cAMP.Papaverine served as the control drug.Results:Icariin and papaverine showed dose-dependent inhibitory effects on PDE5 and PDE4 activities.The IC50 of Icariin and papaverine on PDE5 were 0.432μ mol/L and 0.680μmol/L,respectively and those on PDE4,73.50μmol/L and 3.07μmol/L,respectively.The potencies of selectivity of icariin and papaverine on PDE5(PDE4/PDE5 of IC50)were 167.67 times and 4.54 times,respectively.Conclusion:Icariin is a cGMP-specific PDE5 inhibitor that may be developed into an oral effective agent for the treatment of ED. | ZC Xin EK Kim CS Lin WJ Liu L Tian YM Yuan J Fu | 2003 | Asian Journal of Andrology2003，5，1： | 38 |
| 2 | A metabonomic investigation on the biochemical perturbation in liver failure patients caused by hepatitis b virus显示文摘 | Yu, K Sheng, GP Sheng, JF Chen, YM Xu, W Liu, XL Cao, HC Qu, HB Cheng, YY Li, LJ | 2007 | 中国生物学文摘2007，21，11： | 25 |
| 3 | Isotopic compositions of chlorine in brine and saline minerals显示文摘CHLORINE in the nature has two stable isotopes, 35Cl and 37Cl. Two methods of determining isotopic ratios of chlorine were once developed. Owen, Kaufmann and Long determined 37Cl/35Cl ratios based on the measurement of CH3Cl+ ion produced by ionization of methyl chlorine. The precision of the measurement of Cl-(NTIMS) was reported by Shields and Vengosh. The NTIMS has less precision. | Xiao, YK Liu, WG Zhou, YM Sun, DP | 1997 | Chinese Science Bulletin1997，42，5： | 7 |
| 4 | 环境铅暴露与血压的关系:2003-2010美国健康和营养调查显示文摘在铅暴露逐渐降低的环境下,该文通过分析2003-2010美国健康和营养调查资料,旨在研究血铅与血压、高血压的关系。纳入研究对象12 725人,其中非洲裔21.1%,西语裔20.5%,白人58.4%,女性48.7%。与非非洲裔比较,非洲裔的血压[126.5/71.9比123.9/69.6mm Hg(1mm Hg=0. | Hara A Thijs L Asayama K Gu YM Jacobs L Zhang ZY Liu YP Nawrot TS Staessen JA 刘莉 叶鹏 | 2014 | 中华高血压杂志2014，22，10： | 3 |
| 5 | Effet of Maotai liguor in inducing metallothioneins and on hepatic stellate cells显示文摘 | Cheng ML Wu J Wang HQ Xue LM Tan YZ Liu P Li CX Huang NH Yao YM Ren LZ Ye L Li L Jia ML | 2001 | Shijie Huaren Xiaohua Zazhi2001，9，12： | 2 |
| 6 | Early identification and treatment of PV re-connections : role of observation time and impact on clinical results of atrial fibrillation ablation显示文摘 | Wang XH Liu X Sun YM | 2007 | Europace2007，9，： | 1 |
| 7 | Hydrogen peroxide-induced apoptosis in pc12 cells and the protective effect of puerarin显示文摘 | Jiang B Liu JH Bao YM | 2003 | Cell Biol Int2003，27，12： | 1 |
| 8 | Population alterations of L-arginase-and inducible nitric oxide synthase-expressed CD11b^+/CD14^+/CD15^+/CD33^+ myeloid-derived suppressor cells and CD8^+ T lymphocytes in patients with advanced- stage non-small cell lung cancer 显示文摘 | Liu CY Wang YM Wang CL | 2010 | J Cancer Res Clin Oncol2010，136，1： | 1 |
| 9 | Detection of viable but nonculturable Escherichia coli 0157:H7 bacteria in drinking wa- ter and fiver water显示文摘 | Liu YM Gilchrist A Zhang J | 2008 | Appl Environ Microb2008，74，5： | 1 |
| 10 | Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling 显示文摘 | I-luang SM Mishina YM Liu S | 2009 | Nature2009，461，7264： | 1 |
| 11 | Increased expression of ubiquitin-specific protease 22 can promote cancer progression and predict therapy failure in human colorectal cancer显示文摘 | Liu YL Yang YM Xu H | 2010 | J Gastroenterol Hepatol2010，25，11： | 1 |
| 12 | The partners' inseeure attaehment, depression, and psyehololgieal well-being predictors of diurnal eortisol patterns for breast cancer survivors and their spouses显示文摘 | Jow GM Kuo WH Huang CS Lai YM Liu YF Chang KJ | 2004 | Hsiao FH Stress2004，37，2： | 1 |
| 13 | Changes in susceptibility of Plasmodium falciparum to artesunate in vitro Yunnan Province, China 显示文摘 | Yang HL Liu DQ Yang YM | 2003 | Trans Roy Soc Trop Med Hyg2003，97，3： | 1 |
| 14 | Immunologic variables in acute mania of bipolar disorders 显示文摘 | Liu HC Yang YY Chou YM | 2004 | J Neuroimmunol2004，105，： | 1 |
| 15 | Clinical effect of treatment with lipoprostaglandin E1 on the patients with chronic glomerulonephritis显示文摘 | Zhong WQ Liu GX Yang YM | 2004 | Zhongguo Wei Zhong Bing Ji Jiu Yi Xue2004，16，5： | 1 |
| 16 | Structural basis for the identification f the N terminal domain of coronavirus nucleo- capsid protein as an antiviral target 显示文摘 | Lin SY Liu CL Chang YM | 2014 | Med Chem2014，57，6： | 1 |
| 17 | Aberrant expression of USP22 is associated with liver metastasis and poor prognosis of colorectal cancer显示文摘 | Liu YL Yang YM Xu H | 2011 | J Surg Oncol2011，103，3： | 1 |
| 18 | Hnatowich influence of different chelators(HYNIC, MAG3 and DTPA) on tumor cell accumulation and mouse biodistribution of technetium-99m labeled to antisense DNA 显示文摘 | Zhang YM Liu N Zhu ZH | 2000 | Eur J Nucl Med2000，27，11： | 1 |
| 19 | Ultrahigh-pressure (4.5-5.5 GPa) experimental research on pyroxene-garnet transition and its significance显示文摘Al-PYROXENE in nature may be regarded as garnet solid solution in Al-free pyroxene. The transition from Al-pyroxene to garnet + Al-poor pyroxen can be carried out under high-pressure conditions. Ultrahigh-pressure experiment on pyroxene-garnet transition was carried out in this work using natural soecimens to exolain the genesis of garnet peridotite. | Fan, QC Liu, RX Xie, HS Zhang, YM Lin, ZR | 1997 | Chinese Science Bulletin1997，42，17： | 1 |
| 20 | The relationship between endothelialdysfunction and oxidative stress in diabetes and prediabetes显示文摘 | Su Y Liu XM Sun YM | 2008 | IntJ Clin Pract2008，62，6： | 1 |
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