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| 1 | Effectiveness of intravenous r- tPA versus UK for acute ischaemic stroke: a nationwide prospective Chinese registry study显示文摘Background Intravenous recombinant tissue plasminogen activator(r-tPA)and urokinase(UK)are both recommended for the treatment of acute ischaemic stroke(AIS)in China,but with few comparative outcome data being available.We aimed to compare the outcomes of these two thrombolytic agents for the treatment of patients within 4.5 hours of onset of AIS in routine clinical practice in China.Methods A pre-planned,prospective,nationwide,multicentre,real-world registry of consecutive patients with AIS(age≥18 years)who received r-tPA or UK within 4.5 hours of symptom onset according to local decision-making and guideline recommendations during 2017-2019.The primary effectiveness outcome was the proportion of patients with an excellent functional outcome(defined by modified Rankin scale scores 0 to 1)at 90 days.The key safety endpoint was symptomatic intracranial haemorrhage according to standard definitions.Multivariable logistic regression was used for comparative analysis,with adjustment according to propensity scores to ensure balance in baseline characteristics.Results Overall,4130 patients with AIS were registered but 320 had incomplete or missing data,leaving 3810 with available data for analysis of whom 2666 received r-tPA(median dose 0.88(IQR 0.78-0.90)mg/kg)and 1144 received UK(1.71(1.43-2.00)×104 international unit per kilogram).There were several significant intergroup differences in patient characteristics:r-tPA patients were more educated,had less history of stroke,lower systolic blood pressure,greater neurological impairment and shorter treatment times from symptom onset than UK patients.However,in adjusted analysis,the frequency of excellent outcome(OR 1.18,95%CI 1.00 to 1.40,p=0.052)and symptomatic intracranial haemorrhage(OR 0.70,95%CI 0.33 to 1.47,p=0.344)were similar between groups.Conclusions UK may be as effective and carry a similar safety profile as r-tPA in treating mild to moderate AIS within guidelines in China.Registration http://gffzzd5593dd32ed44506h0bkwp0cow5056bv5.ffgz.tsg.suse.edu.cn identifier:NCT02854592. | Xinhong Wang Xiaoqiu Li Yuming Xu Runhui Li Qingcheng Yang Yong Zhao Fengyun Wang Baoying Sheng Runqing Wang Shaoyuan Chen Lihua Wang Liying Shen Xiaowen Hou Yu Cui Duolao Wang Bin Peng Craig S Anderson Huisheng Chen On behalf of INTRECIS Investigators | 2021 | Stroke & Vascular Neurology2021，6，4： | 2 |
| 2 | Electrocatalytic reduction of chloramphenicol at muhiwall carbon nanotube-modified electrodes 显示文摘 | Lii S F Dang X P Wu K B | 2003 | Journal of Nanosciense and Nanotechnology2003，3，5： | 1 |
| 3 | Maternal prolactin composition can permantently affect epidermal granunadelta T cell function in the offspring显示文摘 | Yang L Lii S Kuo B | 2002 | Dev Comp Immunol2002，26，9： | 1 |
| 4 | Predicting radiolog- ical panel opinions using a panel of machine learning classi- tiers显示文摘 | Zinovev D Raicu D S Furst J Lii S G A | 2009 | Algorithms2009，2，4： | 1 |
| 5 | K (UO) Si206 : A pentavalent uranium silicate 显示文摘 | CHEN C S LEE S F LII K H | 2005 | J Am Chem Soc2005，127，12： | 1 |
| 6 | Parameters identification and synchronization of chaotic systems based upon adaptive control 显示文摘 | Chen S Lii J | 2002 | Physics Letters A2002，299，4： | 1 |
| 7 | Novel Slow-Release Muhielement Compound Fertilizer with Hydroscopieity and Moisture Preservation 显示文摘 | Ni B Liu M Lii S | 2010 | Industrial & Engineering Chemistry Research2010，49，10： | 1 |
| 8 | Xanthan gum-gelatin complexes显示文摘 | Lii C Liaw S C Lai V M F | 2002 | European Polymer Journal2002，38，7： | 1 |
| 9 | Acute evaluation of programmer-guided AV/PV and VV delay optimization comparing an IEGM method and echocardiogram for cardiac resynchronization ther- apy in heart failure patients and dual-chamber ICDs implants显示文摘 | Baker II JH McKenzie lII J Beau S | 2007 | J Cardiovasc Electrophysio12007，18，： | 1 |
| 10 | Doing right leads to doing well: When the type of CSR and reputation interact to affect consumer eval- uations of the firm显示文摘 | Lii Y S Lee M | 2012 | Journal of Business Ethics2012，105，1： | 1 |
| 11 | Analysis of asolar-powered membrane distillation system显示文摘 | Ding Zhongwei Liu Liying Mohamed S E B | 2005 | Desalination2005，，： | 1 |
| 12 | Identifying influential nodes in complex networks 显示文摘 | Chen D Lii L Shang M S | 2012 | Physica A2012，391，4： | 1 |
| 13 | Age-related changes of antioxidant enzyme activities, glutathione status and lipid peroxidation in rat erythrocytes after heat stress 显示文摘 | OzttirkS O Glimti~lii S | 2004 | Life sciences2004，75，13： | 1 |
| 14 | A comparison between the backpropagation and counter-propagation networks in the modeling of the TIG welding process 显示文摘 | Juang S C Tamg Y S Lii H R | 1998 | Journal of Materials Processing Technology1998，75，3： | 1 |
| 15 | Operational Monito- ring of Suspended Matter Distribution Using MO- DIS Images and Nerical Modeling显示文摘 | Liis S Urmas R Tarmo K | 2006 | Advances in Space Research2006，38，： | 1 |
| 16 | The effects of a 12 - week walking program on community - dwelling older adults 显示文摘 | Cheng SP Tsai TI Lii YK Yu S Chou CL Chen IJ | 2009 | Res Q Exere Sport2009，80，3： | 1 |
| 17 | Operational Monitoring of Suspended Matter Distribution Using MODIS Images and Nerical Modeling显示文摘 | Liis S Urmas R Tarmo K | 2006 | Advances in Space Research2006，38，： | 1 |
| 18 | Molecular epidemiology and phylogenetic analysis of a marine fish infectious spleen and kidney necrosis virus-like (ISKNV-like) virus 显示文摘 | Wang Y Q Lii L Weng S P | 2007 | Archives of Virology2007，152，4： | 1 |
| 19 | Photoinhibition in chill- ing stressed wheat and maize显示文摘 | LII~)N F C LOUREIRO A S VIEIRA D E | 2001 | Photosynthetica2001，39，2： | 1 |
| 20 | Materials Science and Engineering A显示文摘 | Lii S L Wu S S Zhu Z M | 2011 | 528: 86352011，528，： | 1 |
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