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336篇 您的检索式:作者名="Lo A K"
    题名 作者 年代 出处 被引量
1Transposon mouse models to elucidate the genetic mechanisms of hepatitis B viral induced hepatocellular carcinoma显示文摘The major type of human liver cancer is hepatocellular carcinoma(HCC), and there are currently many risk factors that contribute to this deadly disease. The majority of HCC occurrences are associated with chronic hepatitis viral infection, and hepatitis B viral(HBV) infection is currently a major health problem in Eastern Asia. Elucidating the genetic mechanisms associated with HBV-induced HCC has been difficult due to the heterogeneity and genetic complexity associated with this disease. A repertoire of animal models has been broadly used to study the pathophysiology and to develop potential treatment regimens for HBVassociated HCC. The use of these animal models has provided valuable genetic information and has been an important contributor to uncovering the factors involved in liver malignant transformation, invasion and metastasis. Recently, transposon-based mouse models are becoming more widely used in liver cancer research to interrogate the genome by forward genetics and also used to validate genes rapidly in a reverse genetic manner. Importantly, these transposon-based rapid reverse genetic mouse models could become crucial in testing potential therapeutic agents before proceeding to clinical trials in human. Therefore, this review will cover the use of transposon-based mouse models toaddress the problems of liver cancer, especially HBVassociated HCC occurrences in Asia.Amy P Chiu Barbara R Tschida Lilian H Lo Branden S Moriarity Dewi K Rowlands David A Largaespada Vincent W Keng 2015World Journal of Gastroenterology2015,21,42:2
2Composting salmon farm mortalities with passive areration显示文摘Liao P H Vizcarra A T Chen A Lo K V 1996Compost Science and Utilization1996,2,4:2
3A capacity related reliability for transportation networks 显示文摘CHEN A YANG H LO H K 1999Journal of Advanced Transportation1999,33,2:1
4A Self-adaptive Pro- jection and Contraction Algorithm for the Traffic As- signment Problem with Path-specific Costs显示文摘CHEN A LO H K YANG H 2001Euro- pean Journal of Operational Research2001,135,1:1
5Capacity reliability of a road network: an assessment methodology and numerical results 显示文摘CHEN A YANG H LO H K 2002Transportation Research2002,36,:1
6Traffic equilibrium problem with route- specific costs: formulation and algorithms 显示文摘LO H K CHEN A 2000Transportation Research Part B2000,34,:1
7Current theories on the pathogenesis of infan- tile hemangioma 显示文摘Lo K Mihm M Fay A 2009Semin Ophthalmol2009,24,3:1
8Halo nevi association in nonsegmental vitiligo affects age at onset and depigmentation pattern 显示文摘Ezzedine K Dia]lo A Laut6-Labrze C 2012Arch Dermatol2012,148,4:1
9A Capacity Related Re- liability for Transportation Networks显示文摘CHEN A YANG H LO H K 1999Journal of Ad- vanced Transportation1999,33,2:1
10Third-order nonlinear optical properties of a soluble conjugated polythiophene derivative显示文摘JENEKHE S A LO S K FLOM S R 1989Applied Physics Letters1989,54,25:1
11Current theories on the pathogenesis of in- fantile hemangioma 显示文摘Lo K Mihm M Fay A 2009Semin Ophthalmol2009,24,3:1
12Diagnosis and conservative management of female stress urinary incontinence显示文摘Dass A K Lo T S Khanuengkitkong S 2013Gynecol Minim Invasive Ther2013,2,2:1
13The effect of humidity and state of water surfaces on deposition of aerosol particles onto a water surface显示文摘LO A K F ZHANG L M SIEVERING H 1999Atmospheric Environment1999,33,28:1
14Vancomycin MIC creep in MRSA isolates from 1997 to 2008 in a healthcare region in Hong Kong显示文摘Ho P L Lo P Y Chow K H et a l 2010J Infect2010,60,11:1
15The impact of environmental management systems on financial performance in fashion and textiles industries显示文摘Lo C K Y Yeung A C L Cheng T C E 2012International Journal of Production Economics2012,135,2:1
16Cell-free nucleic acids in plas-ma ,serum and urine: a new tool in molecular diagnosis显示文摘Chan A K Chiu R W Lo Y M 2003AnnClin Biochem2003,40,2:1
17The effects of Danshen(Salvia mihiorrhiza) on warfarin pharmacodynamics and pharmacokinetics of warfarin enantiomers in rats显示文摘Chart K Lo A C Yeung J H 1995J Pharm Pharmacol1995,47,5:1
18Aeration experiments for swine waste composting 显示文摘 Lo K V Liao P H Yu J C 1992Bioresource Techmology1992,41,:1
19Capacity reliability of a road network: an assessment methodology and numerical results 显示文摘CHEN A YANG H LO H K 2002Transportution Research Part B2002,,36:1
20Control strategies for oversaturatedtraffic显示文摘LO H K CHOW A H F 2004Journal of Transportation Engineering2004,130,4:1
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