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| 1 | Liver expression of steroid hormones and Apolipoprotein D receptors in hepatocellular carcinoma显示文摘AIM: To evaluate the tissular expression of Androgen (A), Estrogen (E) and Progesterone (Pg) receptors, and Apolipoprotein D (ApoD), in liver tumors from resected hepatocellular carcinoma (HCC) cases in order to assess their possible relationship to prognosis. METHODS: We performed an immunohistochemical study using tissue microarrays (containing more than 260 cancer specimens, from 31 HCC patients and controls) to determine the presence of specif ic antibodies against AR, ER, PgR and ApoD, correlating their findings with several clinico-pathological and biological variables. The staining results were categorized using a semi-quantitive score based on their intensity, and the percentage of immunostained cells was measured. RESULTS: A total of 21 liver tumors (67.7%) were positive for AR; 16 (51.6%) for ER; 26 (83.9%) for PgR and 12 (38.7%) stained for ApoD. We have found a wide variability in the immunostaining score values for each protein, with a median (range) of 11.5 (11.5-229.5) for AR; 11.1 (8.5-65) for ER; 14.2 (4-61) for PgR; and 37.7 (13.8-81.1) for ApoD. A history of heavy ethanol consumption, correlated positively with AR and PgR and negatively with ER status. HCV chronic infection also correlated positively with AR and PgR status. However, the presence of ApoD immunostaining did not correlate with any of these variables. Tumors with a positive immuno-staining for PgR showed a better prognosis. CONCLUSION: Our results indicate a moderate clinical value of the steroid receptor status in HCC, emphasizing the need to perform further studies in order to evaluate the possible role of new hormonal-based therapies. | FJ Vizoso M Rodriguez A Altadill ML González-Diéguez A Linares LO González S Junquera F Fresno-Forcelledo MD Corte L Rodrigo | 2007 | World Journal of Gastroenterology2007，13，23： | 11 |
| 2 | Techniques and accuracy of thoracolumbar pedicle screw placement显示文摘Pedicle screw instrumentation has been used to stabilize the thoracolumbar spine for several decades. Although pedicle screws were originally placed via a freehand technique, there has been a movement in favor of pedicle screw placement with the aid of imaging. Such assistive techniques include fluoroscopy guidance and stereotactic navigation. Imaging has the benefit of increased visualization of a pedicle's trajectory, but can result in increased morbidity associated with radiation exposure, increased time expenditure, and possible workflow interruption. Many institutions have reported high accuracies with each of these three core techniques. However, due to differing definitions of accuracy and varying radiographic analyses, it is extremely difficult to compare studies side-by-side to determine which techniques are superior. From the literature, it can be concluded that pedicles of vertebrae within the mid-thoracic spine and vertebrae that have altered morphology due to scoliosis or other deformities are the most difficult to cannulate. Thus, spine surgeons would benefit the most from using assistive technologies in these circumstances. All other pedicles in thethoracolumbar spine should theoretically be cannulated with ease via a free-hand technique, given appropriate training and experience. Despite these global recommendations, appropriate techniques must be chosen at the surgeon's discretion. Such determinations should be based on the surgeon's experience and the specific pathology that will be treated. | Varun Puvanesarajah Jason A Liauw Sheng-fu Lo Ioan A Lina Timothy F Witham | 2014 | World Journal of Orthopedics2014，5，2： | 7 |
| 3 | 立体定向融合影像技术在治疗脑动静脉畸形引发癫痫的定位作用显示文摘目的探讨立体定向结合脑血管造影与MRI影像融合在治疗脑动静脉畸形引发癫痫时对脑功能区、脑内病变和致痫灶空间范围的定位作用。方法对17例患者采用Talairach立体定向系统,绘制脑皮质表面血管图,并与三维MRI成像进行融合,标注脑功能区并设计术前深部电极放置部位和手术方案。结果17例患者获得了清晰的立体脑血管造影与MRI图像,涉及手术部位包括额叶8例、顶叶6例、颞叶2例和枕叶1例。手术完整切除动静脉畸形。术后随访1年,8例未见癫痫发作。结论该技术可以保证术前准确定位病灶,有利于术中判断脑沟回和功能区,避免损伤皮质功能区和血管。 | 赵国光 F Cardinale M Cossu G Lo Russo | 2005 | 中国脑血管病杂志2005，2，7： | 3 |
| 4 | Laser transformation hardening of AISI440C martensitic stainless steel for higher cavitation erosion resistance显示文摘 | Lo K H Cheng F T Man H C | 2003 | Surface and Coating Technology2003，173，： | 2 |
| 5 | A genetic algorithm for the design of a fuzzy controller for active queue management 显示文摘 | Fatta D G Hoffmann F Re Lo G | 2003 | IEEE Trans on System Man and Cybernetic2003，33，3： | 2 |
| 6 | Presence of fetal DNA in maternal plasma and serum显示文摘 | Y M Dennis Lo Noemi Corbetta Paul F Chamberlain Vik Rai Ian L Sargent Christopher WG Redman James S Wainscoat | 1997 | The Lancet1997，，9076： | 2 |
| 7 | White spot syndrome baculovirus(WSBV) detected in cultured and captured shrimp, crabs and other arthropods 显示文摘 | Lo C F Ho C H Peng S E | 1996 | Dis Aquat Org1996，27，： | 1 |
| 8 | Biomechanical correlations of lesions assocjated with traumatic diseases of the anterjor cruciate ligament:Analysis with MR显示文摘 | Demaria M Barbiera F Lo Casto A | 1996 | Radiol Med Torino1996，91，6： | 1 |
| 9 | Detection of inducible nitric oxide synthase and vascular endothelial growth factor in choroidal neovascular membranes显示文摘 | Hattenbach LO Falk B Nurnberger F | 2002 | Ophthalmologica2002，216，3： | 1 |
| 10 | Multicast topology inference from measured end- toend loss显示文摘 | Duffield N Horowitz J LO Presti F | 2002 | IEEE Trans Inform2002，48，： | 1 |
| 11 | Defini-tion of relapse risk and role of nonanthracycline drugsfor consolidation in patients with acute promyelocyticleukemia: A joint study of the PETHEMA andG1MEMA cooperative groups 显示文摘 | SANZ M A LO COCO F MARTIN G | 2000 | Blood2000，96，： | 1 |
| 12 | Valuing Foreign Cur- rency Options with a Mean-Reverting Process : A Study of Hong Kong Dollar 显示文摘 | Hui C H Lo C F Yeung V | 2008 | International Journal of Finance & Econom- ics2008，13，1： | 1 |
| 13 | Higher complication risk of totally implantable venous access port systems in patients with advanced cancer:A single institution retro-spective analysis 显示文摘 | Chang Y F Lo A C Tsai C H | 2013 | Palliat Med2013，27，2： | 1 |
| 14 | Anthro- pogenic carbon distributions in the Atlantic Ocean: Data-based estimates from the Arctic to the Antarctic 显示文摘 | V~izquez-Rodriguez M Touratier F Lo Monaco C | 2009 | Biogeosciences2009，6，3： | 1 |
| 15 | Detection and tissue tropism of white spot syndrome baculuvirus(WSBV) in captured brooders of Penaeus monodon with a special emphasis on reproductive organs 显示文摘 | Lo C F Ho C H Chen C H | 1997 | Dis Aquat Org1997，30，： | 1 |
| 16 | HSV -1 thymidine kinase gene therapy for colorectal adenocarcinoma - derived peritoneal carcinomatosis 显示文摘 | Lechanteur C Princen F Lo Bue S | 1997 | Gene Ther1997，4，11： | 1 |
| 17 | Detection of inducible nitric oxide synthase and vascular endothelial growth factor in choroidal neovascular membranes 显示文摘 | Hattenbach LO Falk B Nurnberger F Koch FH Ohrloff C | 2002 | Ophthalmologica2002，216，3： | 1 |
| 18 | Kinetics g plasma Epstein-Barr virus DNA during radiation therapy for nasopharyngeal carcinoma 显示文摘 | Lo Y M Leung S F Chart L Y | 2000 | Cancer Res2000，60，： | 1 |
| 19 | Acute bilateral vitreo-ret-inal hemorrhage following oxygen-ozone therapyfor lumbar disk herniation 显示文摘 | Lo Giudice G Valdi F Gismondi I | 2004 | Am J Ophthlmol2004，138，： | 1 |
| 20 | Expression of frizzledrelated protein and Wnt-signalling molecules in invasive human breast tumours显示文摘 | Wong S C Lo S F Lee K C | 2002 | J Pathol2002，196，2： | 1 |
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