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| 1 | Chronic pancreatitis and the heart disease:Still terra incognita?显示文摘BACKGROUND It has been suggested that chronic pancreatitis(CP)may be an independent risk factor for development of cardiovascular disease(CVD).At the same time,it seems that congestive heart failure(CHF)and CP share the responsibility for the development of important clinical conditions such as sarcopenia,cachexia and malnutrition due to development of cardiac cachexia and pancreatic exocrine insufficiency(PEI),respectively.AIM To explore the evidence regarding the association of CP and heart disease,more specifically CVD and CHF.METHODS A systematic search of MEDLINE,Web of Science and Google Scholar was performed by two independent investigators to identify eligible studies where the connection between CP and CVD was investigated.The search was limited to articles in the English language.The last search was run on the 1st of May 2019.The primary outcomes were:(1)Incidence of cardiovascular event[acute coronary syndrome(ACS),chronic coronary disease,peripheral arterial lesions]in patients with established CP;and(2)Incidence of PEI in patients with CHF.RESULTS Out of 1166 studies,only 8 were eligible for this review.Studies regarding PEI and CHF showed an important incidence of PEI as well as associated malabsorption of nutritional markers(vitamin D,selenium,phosphorus,zinc,folic acid,and prealbumin)in patients with CHF.However,after substitution of pancreatic enzymes,it seems that,at least,loss of appetite was attenuated.On the other side,studies investigating cardiovascular events in patients with CP showed that,in CP cohort,there was a 2.5-fold higher incidence of ACS.In another study,patients with alcohol–induced CP with concomitant type 3c diabetes had statistically significant higher incidence of carotid atherosclerotic plaques in comparison to patients with diabetes mellitus of other etiologies.Earlier studies demonstrated a marked correlation between the clinical symptoms in CP and chronic coronary insufficiency.Also,statistically significant higher incidence of arterial lesions was found in patients with CP compared to the control group with the same risk factors for atherosclerosis(hypertension,smoking,dyslipidemia).Moreover,one recent study showed that PEI is significantly associated with the risk of cardiovascular events in patients with CP.CONCLUSION Current evidence implicates a possible association between PEI and malnutrition in patients with CHF.Chronic pancreatic tissue hypoxic injury driven by prolonged splanchnic hypoperfusion is likely to contribute to malnutrition and cachexia in patients with CHF.On the other hand,CP and PEI seem to be an independent risk factor associated with an increased risk of cardiovascular events. | Sara Nikolic Ana Dugic Corinna Steiner Apostolos V Tsolakis Ida Marie Haugen Lofman J-Matthias Lohr Miroslav Vujasinovic | 2019 | World Journal of Gastroenterology2019,25,44: | 2 |
| 2 | Landslide suscepti- bility analysis in the Hoa Binh province of Viemam using statistical index and logistic regression显示文摘 | Bui D T Lofman O Revhaug I | 2011 | Natural Haz- ards2011,59,3: | 1 |
| 3 | Land slide suscep- tibility analysis in the Hoa Binh province of Vietnam using statistical index and logistic regression显示文摘 | BUI D T LOFMAN O REVHAUG I | 2011 | Natural Hazards2011,59,3: | 1 |
| 4 | Chlorination by-products and nitrate in drinking water and risk for congenital cardiac defects显示文摘 | Cedergren M I Selbing A J Lofman O | 2002 | Environment Research2002,89,2: | 1 |
| 5 | Childhood leukaemia in areas with different radon levels: a spatial and temporal analysis using GIS 显示文摘 | Kohli S Noorlind B H Lofman O | 2000 | J Epidemiol Community Health2000,54,11: | 1 |
| 6 | Childhood leukaemia in areas ,with different radon levels: a spatial and temporal analysis using GIS 显示文摘 | Kohli S Noorlind Brage H Lofman O | 2000 | J Epidemiol Community Health2000,54,11: | 1 |
| 7 | Common biochemical markers of bone turnover predict future bone loss a 5-year follow-up study显示文摘 | LOFMAN O MAGNUSSON P TOSS G | 2005 | Clin Chim Acta2005,356,12: | 1 |
| 8 | Chlorination byproducts and nitrate in drinking water and risk for congenital cardiac defects显示文摘 | Cedergren MI Selbing AJ Lofman O | 2002 | Environ Res2002,89,2: | 1 |
| 9 | Elements of experiential consumption : an exploratory study显示文摘 | Lofman B | 1991 | Advances in Consumer Research1991,18,1: | 1 |
| 10 | Common biochemical markers of bone turnover predict future bone loss:a 5-year follow-up study显示文摘 | Lofman O Magnusson P Toss G | 2005 | Clin Chim Acta2005,356,12: | 1 |
| 11 | Landslide susceptibility analysis in the Hoa Binh province of Vietnam using statistical index and logistic regression显示文摘 | Bui D T Lofman O Revhaug I | 2011 | Natural Hazards2011,59,3: | 1 |
| 12 | Chlorination byproducts and nitrate in drinking water and risk for congenital cardiac defects显示文摘 | Cedergren MI Selbing Al Lofman O | 2002 | Environ Res2002,89,2: | 1 |
| 13 | Cost and burden of gastroesophageal reflux disease a- mong patients with persistent symptoms despite proton pump inhibitor therapy: an observational study in France 显示文摘 | Varannes SB LOfman HG Karlsson M | 2013 | BMC Gastroenterology2013,13,1: | 1 |
| 14 | Scale and dynamics of a transforming forest landscape 显示文摘 | LOFMAN S KOUKI J | 2003 | For Ecol Manage2003,175,: | 1 |
| 15 | Chlorination byproducts and nitrate in drinking water and risk for congenital cardiac defects显示文摘 | Cedergren MI Selbing AJ Lofman O | 2002 | Environ Res2002,89,2: | 1 |
| 16 | Landslide Susceptibility Analysis in the Hoa Binh Province of Vietnam Using Statistical Index and Logistic Regression显示文摘 | Bui D T Lofman O Revhaug I | 2011 | Nat Hazards2011,59,: | 1 |
| 17 | Common biochemical markers of bone turnover predict future bone loss: a 5-year fol low-up study显示文摘 | Lofman O Magnusson P Toss G | 2005 | Clin Chim Acta2005,356,: | 1 |
| 18 | Internalization of cellular fragments in a human embryo:time-Iapse recordings显示文摘 | Hardarson T Lofman C Coull G | 2002 | Reprod Biomed Online2002,5,1: | 1 |
| 19 | Common bioch emical markers of bone turnover predict future bone loss: a 5- year follow -up study 显示文摘 | Lofman 0 Magnusson P Toss G | 2005 | Clin Chim Acta2005,356,12: | 1 |
| 20 | Changes in hip fracture epidemiology: Redistribution between ages, gen- ders and fracture types 显示文摘 | Lofman O Berglund K Larsson L | 2002 | Osteoporos Int2002,13,1: | 1 |