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| 1 | Th1 cytokines promote T-cell binding to antigen-presenting cells via enhanced hyaluronan production and accumulation at the immune synapse显示文摘Hyaluronan(HA)production by dendritic cells(DCs)is known to promote antigen presentation and to augment T-cell activation and proliferation.We hypothesized that pericellular HA can function as intercellular‘glue’directly mediating T cell–DC binding.Using primary human cells,we observed HA-dependent binding between T cells and DCs,which was abrogated upon pre-treatment of the DCs with 4-methylumbelliferone(4-MU),an agent which blocks HA synthesis.Furthermore,T cells regulate HA production by DCs via T cell-derived cytokines in a T helper(Th)subset-specific manner,as demonstrated by the observation that cell-culture supernatants from Th1 but not Th2 clones promote HA production.Similar effects were seen upon the addition of exogenous Th1 cytokines,IL-2,interferon c(IFN-c)and tumor necrosis factor a(TNF-a).The critical factors which determined the extent of DC–T cell binding in this system were the nature of the pre-treatment the DCs received and their capacity to synthesize HA,as T-cell clones which were pre-treated with monensin,added to block cytokine secretion,bound equivalently irrespective of their Th subset.These data support the existence of a feedforward loop wherein T-cell cytokines influence DC production of HA,which in turn affects the extent of DC–T cell binding.We also document the presence of focal deposits of HA at the immune synapse between T-cells and APC and on dendritic processes thought to be important in antigen presentation.These data point to a pivotal role for HA in DC–T cell interactions at the IS. | Paul L Bollyky Stephen P Evanko Rebecca P Wu Susan Potter-Perigo S Alice Long Brian Kinsella Helena Reijonen Kelly Guebtner Brandon Teng Christina K Chan Kathy R Braun John A Gebe Gerald T Nepom Thomas N Wight | 2010 | Cellular & Molecular Immunology2010，7，3： | 3 |
| 2 | The empirical mode decomposition and the Hilbert spectrum for nonlinear and non-stationary time series analysis显示文摘 | Huang N E Shen Z Long S R | | 0，，： | 3 |
| 3 | The empirical mode decomposition and the Hilbert spectrum for nonlinear and non-stationary time series analysis显示文摘 | Huang N E Shen Z Long S R | | 0，，1971： | 2 |
| 4 | The empirical mode decomposition and the Hilbert spectrum for nonlinear and nonstationary time series analysis显示文摘 | Huang N E Shen Z Long S R | | 0，，1971： | 2 |
| 5 | A confidence limit for theempirical mode decomposition and the Hilbert spectralanalysis显示文摘 | Huang N E Wu M C Long S R | 2003 | Proceedings of the Royal Society London:Series A2003，31，： | 1 |
| 6 | Effects of rising CO2concentration on expression of photosynthrtic protein显示文摘 | Webber A N Nie G Y Long S P | 1994 | Photosynth Res1994，39，： | 1 |
| 7 | A Confidence Limit for the Empirical Mode Decomposition and Hilbert Spectral Analysis显示文摘 | Huang N E Wu M L Long S R | 2003 | Proceedings of the Royal Society of London2003，459，： | 1 |
| 8 | The empirical mode decomposition and the Hilbert spectrum for nonlinear and nonstationary time series analysis 显示文摘 | Huang N E Zheng Shen Long S R | 1998 | Proceedings of the Royal Society A : Mathematical Physical and Engineering Sciences1998，454，1971： | 1 |
| 9 | The empirical mode decomposition and the Hilbert spectrum for nonlinear and non-stationary time series analysis 显示文摘 | Huang N E Shen Z Long S al | 1998 | Proceedings of the Royal Society of London1998，454，： | 1 |
| 10 | The empirical mode decomposition and the Hilbert spectrum for nonlinear and non-stationary time series analysis 显示文摘 | Huang N E Shen Z Long S R | 1998 | Proceedings Of The Royal Society of London Series A-Mathematical Physical And Engineering Sciences1998，454，： | 1 |
| 11 | The empirical modedecomposition and the Hilbert spectrum for nonlinear andnon-stationary time series analysis显示文摘 | HUANG N E SHEN Z LONG S R | 1998 | Proceedings of theRoyal Society of London1998，454，1： | 1 |
| 12 | The empirical mode decomposition and the Hilbert spectrum for non- linear and non- stationary time series analysis显示文摘 | Huang N E Shen Z Long S R | 1998 | Proceedings of the Royal Society of London Series A: Mathematical Physical and Engineering Sciences1998，454，： | 1 |
| 13 | A confidence limit for the empirical mode decomposition and Hilbert spectral analysis 显示文摘 | Huang N E Wu M L C Long S R | 2003 | Proceedings Royal of Society A2003，459，： | 1 |
| 14 | The empirical mode 34 decomposition and the Hilbert spectrum for nonlinear and non-stationary time series analysis 显示文摘 | Huang N E Shen Z Long S R | 1998 | Proceedings of the Royal Society A1998，，454： | 1 |
| 15 | The empirical mode decompo- sition and hilbert spectrum for nonlinear and nonstationary time series analysis显示文摘 | Huang N E Shen Z Long S R | 1998 | Proceedings of the Royal Society of London SERIESA1998，454，： | 1 |
| 16 | The empirical mode decomposition and the Hilbert spectrum for nonlinear and nonstationary time series analysis 显示文摘 | HUANG N ZHENG S LONG S | 1998 | Proccess Royal Society Lond1998，454，： | 1 |
| 17 | The empir- ical mode decomposition and the Hilbert spectrum for nonlinear and non-stationary time series analysis 显示文摘 | Huang N E Shen Zheng Long S R | 1998 | Proceeding of the Royal Society A: Mathematical Phys- ical & the Engineering Sciences1998，，： | 1 |
| 18 | The empirical mode decomposition and the Hilberl spectrum for nonlinear and non-stationary time series analysis显示文摘 | Huang N E Shen Z Long S R | 1998 | The Royal Society1998，454，1971： | 1 |
| 19 | Acclimation of photosynthetic proteins to rising atmospheric CO2显示文摘 | Webber A N Nie G Long S P | 1994 | Photosynthesis Res1994，39，： | 1 |
| 20 | Assessment of synthetic peptides of severe acute respiratory syndrome coronavirus recognized by long-lasting immunity 显示文摘 | Shichijo S Keicho N Long H T | 2004 | Tissue Antigens2004，64，5： | 1 |
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