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| 1 | MicroRNA-34a inhibits glioblastoma growth by targeting multiple oncogenes显示文摘 | Li Y Guessous F Zhang Y Dipierro C Kefas B Johnson E Marcinkiewicz L Jiang J Yang Y Schmittgen TD Lopes B Schiff D Purow B Abounader R | 2009 | 中国神经肿瘤杂志2009，7，4： | 56 |
| 2 | Relationship between Th17 immune response and cancer显示文摘Cancer is the second leading cause of death worldwide and epidemiological projections predict growing cancer mortality rates in the next decades.Cancer has a close relationship with the immune system and,although Th17 cells are known to play roles in the immune response against microorganisms and in autoimmunity,studies have emphasized their roles in cancer pathogenesis.The Th17 immune response profile is involved in several types of cancer including urogenital,respiratory,gastrointestinal,and skin cancers.This type of immune response exerts pro and antitumor functions through several mechanisms,depending on the context of each tumor,including the protumor angiogenesis and exhaustion of T cells and the antitumor recruitment of T cells and neutrophils to the tumor microenvironment.Among other factors,the paradoxical behavior of Th17 cells in this setting has been attributed to its plasticity potential,which makes possible their conversion into other types of T cells such as Th17/Treg and Th17/Th1 cells.Interleukin(IL)-17 stands out among Th17-related cytokines since it modulates pathways and interacts with other cell profiles in the tumor microenvironment,which allow Th17 cells to prevail in tumors.Moreover,the IL-17 is able to mediate pro and antitumor processes that influence the development and progression of various cancers,being associated with variable clinical outcomes.The understanding of the relationship between the Th17 immune response and cancer as well as the singularities of carcinogenic processes in each type of tumor is crucial for the identification of new therapeutic targets. | Hanna Santos Marques Breno Bittencourt de Brito Filipe Antônio França da Silva Maria Luísa Cordeiro Santos Júlio César Braga de Souza Thiago Macêdo Lopes Correia Luana Weber Lopes Nayara Silva de Macêdo Neres Rafael Santos Dantas Miranda Dórea Anna Carolina Saúde Dantas Lorena Lôbo Brito Morbeck Iasmin Souza Lima Amanda Alves de Almeida Maiara Raulina de Jesus Dias Fabrício Freire de Melo | 2021 | World Journal of Clinical Oncology2021，12，10： | 5 |
| 3 | Interleukin-6-174G/C polymorphism is associated with a decreased risk of type 2 diabetes in patients with chronic hepatitis C virus显示文摘BACKGROUND Chronic hepatitis C(CHC)is associated with type 2 diabetes mellitus.Although the pathogenesis remains to be elucidated,a growing evidence has suggested a role of pro-inflammatory immune response.Increased serum concentrations of Interleukin 6(IL-6)have been associated with insulin resistance,type 2 diabetes mellitus as well as advanced forms of liver disease in chronic hepatitis C infection.AIM To investigate the frequency of IL-6-174G/C(rs1800795)single nucleotide polymorphism(SNP)in CHC patients and in healthy subjects of the same ethnicity.Associations between type 2 diabetes mellitus(dependent variable)and demographic,clinical,nutritional,virological and,IL-6 genotyping data were also investigated in CHC patients.METHODS Two hundred and forty-five patients with CHC and 179 healthy control subjects(blood donors)were prospectively included.Type 2 diabetes mellitus was diagnosed according to the criteria of the American Diabetes Association.Clinical,biochemical,histological and radiological methods were used for the diagnosis of the liver disease.IL-6 polymorphism was evaluated by Taqman SNP genotyping assay.The data were analysed by logistic regression models.RESULTS Type 2 diabetes mellitus,blood hypertension and liver cirrhosis were observed in 20.8%(51/245),40.0%(98/245)and 38.4%(94/245)of the patients,respectively.The frequency of the studied IL-6 SNP did not differ between the CHC patients and controls(P=0.81)and all alleles were in Hardy-Weinberg equilibrium(P=0.38).In the multivariate analysis,type 2 diabetes mellitus was inversely associated with GC and CC genotypes of IL-6-174(OR=0.42;95%CI=0.22-0.78;P=0.006)and positively associated with blood hypertension(OR=5.56;95%CI=2.79-11.09;P<0.001).CONCLUSION This study was the first to show that GC and CC genotypes of IL-6-174 SNP are associated with a decreased risk of type 2 diabetes mellitus in patients chronically infected with hepatitis C virus.The identification of potential inflammatory mediators involved in the crosstalk between hepatitis C virus and the axis pancreas-liver remains important issues that deserve further investigations. | Cliviany Borges da Silva Diego Alves Vieira Luisa Freitas de Melo Anna Luiza Soares Chagas Adriana Dias Gomes César Lúcio Lopes de Faria Jr Rosangela Teixeira Dulciene Maria de Magalh?es Queiroz Gifone Aguiar Rocha Maria Marta Sarquis Soares Juliana Maria Trindade Bezerra Luciana Diniz Silva | 2020 | World Journal of Hepatology2020，12，4： | 2 |
| 4 | Defining control strategies for microgrids islanded operation 显示文摘 | LOPES J A P MOREIRA C L MADUREIRA A G | 2006 | IEEE Trans on Power Systems2006，21，91： | 1 |
| 5 | Atrial fibrillation and acute myocardial infarction: antithrombotic therapy and outcomes显示文摘 | Lopes R D Li L Granger C B | 2012 | The American J0umal of Medicine2012，125，9： | 1 |
| 6 | Linear and nonlinear dynamics of cantilevered cylinders in axial flow, Part 2 : the equation of motion 显示文摘 | J L Lopes M P Paidoussis C Semler | 2002 | Journal of Fluids and Structures2002，16，6： | 1 |
| 7 | A purine scaffold Hsp90 inhibitor destabilizes BCL-6 and has specific antitumor activity in BCL-6 -dependent B cell lymphomas显示文摘 | Cerchietti L C Lopes E C Yang S N | | Nat Med0，15，1： | 1 |
| 8 | Effect of bleaching agents on the hardness and morphology of enamel 显示文摘 | Lopes G C Bonissoni L Baratieri L N | 2002 | J Esther Restor Dent2002，14，1： | 1 |
| 9 | Defining control strategies for microgrids islanded operation显示文摘 | LOPES J A P MOREIRA C L MADUREIRA A G | 2006 | IEEE Trans Power Syst2006，21，2： | 1 |
| 10 | Defining con- trol strategies for microgrids islanded operation 显示文摘 | Lopes J A P Moreira C L Madureira A G | 2006 | IEEE Trans on Power Systems2006，21，2： | 1 |
| 11 | Anti-inflammatory effect of physical training in heartfailure:role of TNF-alpha and IL-10显示文摘 | BATISTA M L Jr LOPES R D SEELAENDER M C | 2010 | Cardiol2010，95，2： | 1 |
| 12 | Panic disorder and social anxiety disorder subtypes in a caffeine challenge test显示文摘 | Nardi A E Lopes F L Freire R C | | 0，，02： | 1 |
| 13 | Characteristic interactions with phosphatidylinositol4,5-bisphosphate determine regulation of Kir channels by diverse modulators 显示文摘 | Du X N Zhang H L Lopes C | 2004 | J Biol Chem2004，279，37： | 1 |
| 14 | Performance assessment of active frequency drifting islanding detection methods显示文摘 | Lopes L A C Sun H | 2006 | IEEE Transactions on Energy Conversion2006，21，1： | 1 |
| 15 | Acoustic similarity scores for keyword spotting 显示文摘 | Veiga A Lopes C Sd L | 2014 | Computational Processing of the Portuguese Language2014，8775，： | 1 |
| 16 | Effect of cigarette smoking on serum alpha-tocopherol and the lipid profile in a Portuguese population显示文摘 | LOPES P A SANTOS M C VICENTE L VIEGAS-CRESPO A M | 2004 | Clin Chim Acta2004，348，12： | 1 |
| 17 | Electric load fore- casting using a fuzzy ART&ARTMAP neural network显示文摘 | LOPES M L M MINUSSI C R LOTUFO A D P | 2005 | Applied Soft Computing2005，5，2： | 1 |
| 18 | Effects of Deficit Irrigation Strategies on Cluster Microclimate for Improving Fruit Composition of Moscatel field-grown Grapevines显示文摘 | Dos Santos T P Lopes C M Rodrigues M L | 2007 | Scientia Horticuhurae2007，112，3： | 1 |
| 19 | Evaluation of the detoxification of brewery's spent grain hydrolysate for xylitol production by Debaryomyces hansenii CCMI 941显示文摘 | Carvalheiro F Duarte L C Lopes S | 2005 | Process Biochemistry2005，40，3： | 1 |
| 20 | Coordinated active power curtailment of grid-connected PV inverters for overvohage prevention 显示文摘 | Tonkoski R Lopes L A C El-fouly T I-I M | 2011 | Sustainable Energy IEEE Transactions on2011，2，2： | 1 |
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