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| 1 | Portal hypertension in polycystic liver disease patients does not affect wait-list or immediate post-liver transplantation outcomes显示文摘AIM To establish the impact of portal hypertension(PH) on wait-list/post-transplant outcomes in patients with polycystic liver disease(PCLD) listed for liver transplantation. METHODS A retrospective single-centre case controlled study of consecutive patients listed for liver transplantation over 12 years was performed from our centre. PH in the PCLD cohort was defined by the one or more of following parameters:(1) presence of radiological or endoscopic documented varices from our own centre or the referral centre;(2) splenomegaly(> 11 cm) on radiology inabsence of splenic cysts accounting for increased imaging size;(3) thrombocytopenia(platelets < 150 × 109/L); or(4) ascites without radiological evidence of hepatic venous outflow obstruction from a single cyst. RESULTS Forty-seven PCLD patients(F: M = 42: 5) were listed for liver transplantation(LT)(single organ, n = 35; combined liver-kidney transplantation, n = 12) with 19 patients(40.4%) having PH. When comparing the PH group with non-PH group, the mean listing age(PH group, 50.6(6.4); non-PH group, 47.1(7.4) years; P = 0.101), median listing MELD(PH group, 12; non-PH group, 11; P = 0.422) median listing UKELD score(PH group, 48; non-PH group, 46; P = 0.344) and need for renal replacement therapy(P = 0.317) were similar. In the patients who underwent LT alone, there was no difference in the duration of ICU stay(PH, 3 d; non-PH, 2 d; P = 0.188), hospital stay length(PH, 9 d; non-PH, 10 d; P = 0.973), or frequency of renal replacement therapy(PH, 2/8; non-PH, 1/14; P = 0.121) in the immediate post-transplantation period. CONCLUSION Clinically apparent portal hypertension in patients with PCLD listed for liver transplantation does not appear to have a major impact on wait-list or peri-transplant morbidity. | Neil Rajoriya Dhiraj Tripathi Joanna A Leithead Bridget K Gunson Sophie Lord James W Ferguson Gideon M Hirschfield | 2016 | World Journal of Gastroenterology2016，22，45： | 2 |
| 2 | Percutaneous sclerotherapy for lymphatic malformations:a retrospective analysis of patient-evaluated improvement显示文摘 | Alomari A I Karian V E Lord D J | 2006 | J Vasc Interv Radiol2006，17，10： | 1 |
| 3 | The DNA damage response and cancer therapy显示文摘 | Lord C J Ashworth A | | 0，，： | 1 |
| 4 | Investigating Semantic Similarity Measures Across the Gene Ontology: The Relationship Between Sequence and Annotation 显示文摘 | Lord P W Stevens R D Brass A | 2003 | Bioinformatics2003，19，10： | 1 |
| 5 | The Madigan prostatectomy 显示文摘 | Dixon A R Lord P H Madigan M R | 1990 | J Urol1990，144，： | 1 |
| 6 | NLK is a novel therapeutic target for PTEN deficient tumour cells显示文摘 | Mendes-Pereira A M Lord C J Ashworth A | 2012 | PLoS One2012，7，47： | 1 |
| 7 | Leptin prevents the fall in plasma osteocalcin during starvation in male mice显示文摘 | Goldstone A P Howard J K Lord G M | 2002 | Biochem Biophys Res Commun2002，295，2： | 1 |
| 8 | Targeted therapy for cancer using PARP inhibitors显示文摘 | Lord CJ Ashworth A | 2008 | Curr Opin Pharmacol2008，8，： | 1 |
| 9 | Effectiveness and cost-effec- tiveness of sentinellymph node biopsy compared with axillary node dissection in patients with early stagebreast cancer: a deci sion model analysis显示文摘 | Verry H Lord SJ Martin A | 2012 | Cancer2012，106，6： | 1 |
| 10 | Modulation of peroxisome proliferator-activated re-ceptor delta and gamma transcripts in swine endome-trial tissue during early gestation显示文摘 | LORD E MURPHY B D DESMARAIS J A | 2006 | Reproduction2006，131，5： | 1 |
| 11 | The gona- dotrophin-releasing hormone receptor maps to sheep chro- mosome 6 outside of the region of the FecB locus 显示文摘 | Montgomery G W Penty J M Lord E A | 1995 | Mammalian Genome: Official Journal of the International Mammalian Genome Society1995，6，6： | 1 |
| 12 | Acquiring new knowledge: The role of retaining human capital in acquisitions of high-tech firms 显示文摘 | Ranft A L Lord M D | 2000 | Journal of High Technology Management Research2000，11，： | 1 |
| 13 | Operating temperatures of oil lubricated medium speed gears: Numerical models and experimental results显示文摘 | Long H Lord A A Gethin D T | 2003 | Journal of Aerospace Engineering2003，217，2： | 1 |
| 14 | Therapeutic targeting of the DNA mismatch repair pathway 显示文摘 | Martin SA Lord C J Ashworth A | 2010 | Clin Cancer Res2010，16，21： | 1 |
| 15 | Sampling technique to discriminate the different tissue layers of growing antler tips for gene discovery显示文摘 | Li C Clark D E Lord E A | 2002 | Anat Rec2002，268，2： | 1 |
| 16 | Sampling technique to discriminate the different tissue layers of growing antler tips for gene discovery显示文摘 | Li C Clark D E Lord E A | 2002 | Anat Rec2002，268，2： | 1 |
| 17 | Operating Temperatures of Oil-lubricated medium-speed Gears:Numerical Models and Experimental Results显示文摘 | Long H Lord A A Gethin D T | 2003 | Journal of Aerospace Engineering2003，21，2： | 1 |
| 18 | Operating temperatures ofoil -lubricated mediumspeed gears: numerical models and experimental results显示文摘 | H Long A A Lord D T Gethin | 2003 | Journal of aerospace engineering2003，217，2： | 1 |
| 19 | Design, synthesis, and evaluation in vitro of quinoline-8-carboxamides, a new class of poly ( adenosine-diphosphate-ribose ) polymerase-1 (PARP-1) inhibitor显示文摘 | LORD A MAHON M F THREADGRILL M D | 2009 | JMed Chem2009，52，3： | 1 |
| 20 | Organizational learning about new international markets:exploring the internal transfer of local market knowledge显示文摘 | Lord M D Ranft A L | 2000 | Journal of International Business Studies2000，31，57： | 1 |
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