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| 1 | FOLFIRI plus bevacizumab as a second-line therapy for metastatic intrahepatic cholangiocarcinoma显示文摘AIM:To evaluate the efficacy and tolerance of FOLFIRI plus bevacizumab treatment outcome as second-line treatment for metastatic intrahepatic cholangiocarcinoma.METHODS:Thirteen consecutive patients with metastatic intrahepatic cholangiocarcinoma who were refractory tofirst-line therapy consisting of gemcitabine plus oxaliplatinbased first-line chemotherapy given intravenously via intra-arterial infusion were treated with FOLFIRI[irinotecan(180 mg/m2 i.v.over 90 min)concurrently with folinic acid(400 mg/m2 i.v.over 120 min)followed by fluorouracil(400 mg/m2 i.v.bolus)then fluorouracil 2400 mg/m2 intravenous infusion over 46 h]and bevacizumab(5mg/kg)every 2 wk.Tumor response was evaluated by computed tomography scan every 4 cycles.RESULTS:The best tumor responses using response evaluation criteria in solid tumor criteria were:complete response for 1 patient,partial response for 4 patients,and stable disease for 6 patients after 6 mo of follow-up.The response rate was 38.4%(95%CI:12.5-89)and the disease control rate was 84.5%(95%CI:42-100).Seven deaths occurred at the time of analysis,progression free survival was 8 mo(95%CI:7-16),and median overall survival was 20 mo(95%CI:8-48).No grade 4toxic events were observed.Four grade 3 hematological toxicities and one grade 3 digestive toxicity occurred.An adaptive reduction in chemotherapy dosage was required in 2 patients due to hematological toxicity,and a delay in chemotherapy cycles was required for 3 patients.CONCLUSION:FOLFIRI plus bevacizumab combination treatment showed promising efficacy and safety as second-line treatment for metastatic intrahepatic cholangiocarcinoma after failure of the first-line treatment of gemcitabine plus oxaliplatin chemotherapy. | Jean-Florian Guion-Dusserre Veronique Lorgis Julie Vincent Leila Bengrine Francois Ghiringhelli | 2015 | World Journal of Gastroenterology2015，21，7： | 2 |
| 2 | Prognostic value of chemotherapy-induced hematological toxicity in metastatic colorectal cancer patients显示文摘AIM: To establish whether chemotherapy-induced neutropenia is predictive of better outcome in patients with metastatic colorectal cancer(mCRC). METHODS: Survival and patient characteristics from consecutive mCRC patients treated in the Centre Georges Francois Leclerc, Dijon, France between January 2001 and December 2011 were analyzed. Patient and tumor characteristics, hematological toxicity(neutropenia, anemia, and thrombocytopenia), and type of chemotherapy received were recorded. RESULTS: We retrospectively analyzed data from 399 consecutive patients with mCRC who received at least one line of chemotherapy. Median follow up was 6.3 years. Eighty-eight percent of the patients received more than two lines of chemotherapy. By univariate analysis, whatever their grade, neutropenia and thrombocytopenia occurring during the first two lines of chemotherapy were significantly associated with better overall survival(HR = 0.55, 95%CI: 0.43-0.70, P < 0.0001 and HR = 0.70, 95%CI: 0.56-0.88, P = 0.025 respectively). In contrast, anemia during chemotherapy was significantly associated with poorer overall survival(HR = 1.9, 95%CI: 1.22-2.97, P = 0.005). Multivariate analysis revealed that both neutropenia and thrombocytopenia were significantly associated with better overall survival: HR = 0.43, 95%CI: 0.29-0.64, P < 0.0001 and HR = 0.69, 95%CI: 0.49-0.98, P = 0.036, respectively. CONCLUSION: These data suggest that occurrence of neutropenia or thrombocytopenia during first- or second-line chemotherapy for mCRC is associated with better survival. | Laurie Rambach Aurelie Bertaut Julie Vincent Veronique Lorgis Sylvain Ladoire Francois Ghiringhelli | 2014 | World Journal of Gastroenterology2014，20，6： | 2 |
| 3 | High levels of N terminal pro B-type natriuretic peptide are associated with ST resolution failure after reperfusion for acute myocardial infarction显示文摘 | Lorgis L Zeller M Dentan G | 2007 | QJM2007，100，4： | 1 |
| 4 | Comparative analysis of patients with acute coronary and cerebrovascularsyndromes from the national French hospitalization health care system database 显示文摘 | Bejot Y Benzenine E Lorgis L | 2011 | Neuroepidemiology2011，37，34： | 1 |
| 5 | Prognostic value of N-terminal probrain natriuretic peptide in elderly people with acute myocardial infarction:Prospective observational study显示文摘 | Lorgis L Zeller M Dentan G | 2009 | BMJ2009，338，： | 1 |
| 6 | Prevalence, incidence,predictive factors and prognosis of silent myocardial infarction: a review of the literature显示文摘 | VALENSI P LORGIS L COTTIN Y | 2011 | Arch Cardiovasc Dis2011，104，3： | 1 |
| 7 | Brain-Derived Neurotro phic Factor (BDNF) : Role of this neurotrophin in cardiovascular physiopathology显示文摘 | Lorgis L Amoureux S Vergely C | 2009 | Annales de Cardiologie et d'' Ang6iologie2009，58，： | 1 |
| 8 | Prognostic value of N - termi- nal pro - brain natriuretic peptide in elderlypeople with acute myo- cardial infarction : prospectiveobservational study显示文摘 | Lorgis L Zeller M Dentan G | 2009 | BMJ2009，338，8： | 1 |
| 9 | Prognostic value of N-terminal pro-brain Natriuretic peptide in elderly people with acute myocardial infayction: prospective observation- at strdy显示文摘 | Lorgis L Zeller M Dentan G | 2009 | BMJ2009，338，： | 1 |
| 10 | Prognostic value of N - terminal pro~ brain natriuretic peptide in elderly people with acute myocardial in-farction :prospective observational study 显示文摘 | Lorgis L Zeller M Dentan G | 2009 | BMJ2009，338，： | 1 |
| 11 | Comparative analysis of paIients with acute coronary and cerebrovaseular syndromes from the national French hospitalization health care system database 显示文摘 | B 6 jot Y Benzenine E Lorgis L | 2011 | Neuroepidemiology2011，37，34： | 1 |
| 12 | Prognostic value of N-terminal pro-brain natriuretic peptide in elderly people with acute myocardial infarction:prospective observational study显示文摘 | Lorgis L Zeller M Dentan G et at | 2009 | BMJ2009，338，： | 1 |
| 13 | Discordance in early breast cancer for tumour grade,estrogen receptor,progesteron receptors and human epidermal receptor-2status between core needle biopsy and surgical excisional primary tumour显示文摘 | Lorgis V Algros M P Villanueva C | 2011 | Breast2011，20，3： | 1 |
| 14 | Original article:Impact of obesity on the prognostic value of the N-terminal pro-B-type natriuretic peptide (NT-proBNP)in patients with acute myocardial infarction 显示文摘 | Lorgis L Cottin Y Danchin N | 2011 | Heart2011，97，： | 1 |
| 15 | Brain-Derived Neurotrophic Factor (BDNF) :role of this neurotrophin in cardiovascular physio- pathology 显示文摘 | Lorgis L Amoureux S Vergely C | 2009 | Ann Cardiol Angeiol ( Paris )2009，58，2： | 1 |
| 16 | Prognostic value of frag?mented QRS on a 12-lead ECG in patients with acute myocardial infarction显示文摘 | Lorgis L Jourda F Hachet 0 | 2013 | Heart Lung2013，42，5： | 1 |
| 17 | Prognostic value of fragmen- ted QRS on a 12 -lead ECG in patients with acute myocardial in- farction显示文摘 | Lorgis L Jourda F Hachet O | 2013 | Heart Lung2013，42，5： | 1 |
| 18 | Prognostic value of N - terminal probrain natriuretic peptide in elderly people with acute myocardiat infarction: prospective observational study显示文摘 | Lorgis L Zeller M Dentan G et at | 2009 | BMJ2009，338，： | 1 |
| 19 | Prognostic value of fragmented QRS on a 12-lead ECG in patients with acute myocardial infarction 显示文摘 | Lorgis L Jourda F Hachet O | 2013 | Heart Lung2013，42，5： | 1 |
| 20 | Prognostic value offragm ented Q RS on a 12-lead ECG in patients w ith acutem yocardial in farctio n 显示文摘 | Lorgis L Jo u rd a F H achet 0 9 | | H eart L un g0，42，32： | 1 |
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