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| 1 | Dysfunctional stem and progenitor cells impair fracture healing with age显示文摘Successful fracture healing requires the simultaneous regeneration of both the bone and vasculature;mesenchymal stem cells (MSCs) are directed to replace the bone tissue, while endothelial progenitor cells (EPCs) form the new vasculature that supplies blood to the fracture site. In the elderly, the healing process is slowed, partly due to decreased regenerative function of these stem and progenitor cells. MSCs from older individuals are impaired with regard to cell number, proliferative capacity, ability to migrate, and osteochondrogenic differentiation potential. The proliferation, migration and function of EPCs are also compromised with advanced age. Although the reasons for cellular dysfunction with age are complex and multidimensional, reduced expression of growth factors, accumulation of oxidative damage from reactive oxygen species, and altered signaling of the Sirtuin-1 pathway are contributing factors to aging at the cellular level of both MSCs and EPCs. Because of these geriatric-specific issues, effective treatment for fracture repair may require new therapeutic techniques to restore cellular function. Some suggested directions for potential treatments include cellular therapies, pharmacological agents, treatments targeting age-related molecular mechanisms, and physical therapeutics. Advanced age is the primary risk factor for a fracture, due to the low bone mass and inferior bone quality associated with aging;a better understanding of the dysfunctional behavior of the aging cell will provide a foundation for new treatments to decrease healing time and reduce the development of complications during the extended recovery from fracture healing in the elderly. | Diane R Wagner Sonali Karnik Zachary J Gunderson Jeffery J Nielsen Alanna Fennimore Hunter J Promer Jonathan W Lowery M Terry Loghmani Philip S Low Todd O McKinley Melissa A Kacena Matthias Clauss Jiliang Li | 2019 | World Journal of Stem Cells2019，11，6： | 3 |
| 2 | Variation in open reading frames 3, 4 and 7 among porcine reproductive and respiratory syndrome virus isolates in the UK 显示文摘 | Drew T W Lowings J P Yapp F | 1997 | Vet Microbiol1997，55，14： | 1 |
| 3 | Heuristic solutions to multidepot location-routing problem显示文摘 | Wu T H Low C Bai J W | 2002 | Computers&Operations Research2002，29，： | 1 |
| 4 | Efficient system reliability analysis illustrated for a retaining wall and a soil slope显示文摘 | LOW B K ZHANG J TANG W H | 2011 | Computers and Geotechnics2011，38，2： | 1 |
| 5 | Surface modification of gold nanorods with polymers synthesized by reversible addition-fragmentation chain transfer polymerization 显示文摘 | Hotchkiss J W Lowe A B Boyes S G | 2007 | Chem Mater2007，19，： | 1 |
| 6 | Tumor suppressive functions of p53 显示文摘 | ZILFOU J T LOWE S W | 2009 | Cold Spring Harb Perspect Biol2009，1，5： | 1 |
| 7 | Video parsing and browsing using compressed data 显示文摘 | Zhang H J Low C Y Smoliar S W | 1995 | Multimedia Tools and Applications1995，1，1： | 1 |
| 8 | Is there a potential therapeutic value of copper & zinc for osteopo- rosis显示文摘 | Lowe N M Fraser W D Jackson M J | 2002 | Proc Nutr Soc2002，61，： | 1 |
| 9 | Heuristic solutions to multi-depot location-routing problems显示文摘 | Wu T H Low C Bai J W | 2002 | Computers and Operations Research2002，9，10： | 1 |
| 10 | Heuristic solutions to multi- depot location-routing problems 显示文摘 | Wu T H Low C Bai J W | 2002 | Computers and Operations Research2002，29，： | 1 |
| 11 | A framework for intelligent medical diagnosis using the theory of evidence显示文摘 | Jones R W Lowe A Harrison M J | 2002 | Knowledge- Based Systems2002，15，： | 1 |
| 12 | Seismic design and performance of self-centering steel plate shear walls 显示文摘 | CLAYTON P M BERMAN J W LOWES L N | 2012 | Journal of Structural Engineering2012，138，1： | 1 |
| 13 | Antimicrobial efficacy of silver ions in combination with tea tree oil against Pseudomonas aeruginoso, Staphylococcus aureus and Candida albicans显示文摘 | Low W L Martin C Hill D J | 2011 | International Journal of Antimicrobial Agents2011，37，2： | 1 |
| 14 | The spitzer space telescope mission 显示文摘 | M W Werner T L Roellig F J Low | 2004 | The Astrophysical Journal Supplement Series2004，154，： | 1 |
| 15 | Synthesis and evaluation of taxol-folic acid conjugates as targeted antineoplastics 显示文摘 | LEE J W LU J Y LOW P S | 2002 | Bioorg Med Chem2002，10，7： | 1 |
| 16 | Enhanced photocatalytic CO2-reduction activity of anatase Ti O2by coexposed{001}and{101}facets显示文摘 | Yu J Low J Xiao W | 2014 | Journal of the American Chemical Society2014，136，25： | 1 |
| 17 | The use ofnanoimprint lithography to improve efficiencies of bilayer organic solar cells based on P3HT and a small molecule acceptor 显示文摘 | Zeng W J Chong K S L Low H Y | 2009 | Thin Solid Films2009，517，24： | 1 |
| 18 | Assessment of hub status among Asian ports from a network perspective 显示文摘 | Low J M W Lam S W Tang L C | 2009 | Transportation Research Part A2009，，43： | 1 |
| 19 | Automatic partition of full-motion video 显示文摘 | Zhang H J Low C Y Smoliar S W | 1993 | Multimedia Systems1993，，1： | 1 |
| 20 | A sottware tool for the quantitative evaluation of 3D dose calculation al- gorithms 显示文摘 | Harms W B Low D A Wong J W | 1998 | Med Phys1998，25，10： | 1 |
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